22596-62-9

Basic information

• Product Name: N-(2-PHENYL-PROPYL)-ACETAMIDE
• Synonyms: N-(2-PHENYL-PROPYL)-ACETAMIDE;N-(β-Methylphenethyl)acetamide
• CAS NO: 22596-62-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 22596-62-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 342.8°Cat760mmHg
• Flash Point: 203.1°C
• Appearance: /
• Density: 0.993g/cm³
• Vapor Pressure: 7.36E-05mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: N-(2-PHENYL-PROPYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-PHENYL-PROPYL)-ACETAMIDE(22596-62-9)
• EPA Substance Registry System: N-(2-PHENYL-PROPYL)-ACETAMIDE(22596-62-9)

Safety Data

• Hazardous Substances Data: 22596-62-9(Hazardous Substances Data)

Usage

General Description

N-(2-Phenyl-propyl)-acetamide is a chemical compound with the molecular formula C12H15NO. It is an amide derivative of acetaminophen, commonly known as Tylenol. N-(2-Phenyl-propyl)-acetamide is a white crystalline powder that is used as an analgesic and antipyretic medication. It works by inhibiting the production of prostaglandins in the brain, which are responsible for causing pain and fever. This chemical compound is commonly used in over-the-counter and prescription medications to relieve mild to moderate pain and reduce fever. N-(2-Phenyl-propyl)-acetamide has a mild and generally well-tolerated side effect profile when used at recommended doses, making it a popular choice for pain relief and fever reduction.

InChI:InChI=1/C11H15NO/c1-9(8-12-10(2)13)11-6-4-3-5-7-11/h3-7,9H,8H2,1-2H3,(H,12,13)

Upstream product

• 692-33-1 N-allylacetamide 
• 71-43-2 benzene 
• 582-22-9 2-phenylpropylamine 
• 75-36-5 acetyl chloride 
• 72-89-9 acetylcoenzyme A 
• 20388-87-8 rac-β-methylphenethylamine hydrochloride 
• 108-24-7 acetic anhydride 
• 34713-70-7 2-Phenylpropanal 
• 98-86-2 acetophenone 
• 2085-88-3 2-methyl-2-phenyloxirane 
• 20780-53-4 (R)-Styrene oxide 
• 141-78-6 ethyl acetate 
• 108-05-4 vinyl acetate 

Downstream Products

• 59261-37-9 1,4-dimethyl-3,4-dihydroisoquinoline 
• 71825-43-9 N-[2-(4-nitrophenyl)propyl]acetamide 
• 162662-88-6 2-(2-phenylpropyl)-1H-isoindole-1,3(2H)-dione 
• 1721-95-5 1,4-Dimethyl-isochinolin 

Relevant articles and documents

Quinazoline derivatives and its preparation method and application

The invention relates to quinazoline derivatives and its preparation method and application. The quinazoline derivatives with The structural formula, the quinazoline derivative to gefitinib for the positive control, the result shows that compared with the gefitinib has good activity; and lead compound OTS514 compared, equivalent activity, PBK/TOPK inhibitors for further transformation and the discovery of new anti-tumor medicine phenological shopping has higher learning with the reference value. The invention also provides a preparation method of the quinazoline derivatives and the preparation of PBK/TOPK inhibitor and an anticancer drug.

Biocatalytic N-Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis

A straightforward one-step biocatalyzed synthesis of different N-acyl amides in water was accomplished using the versatile and chemoselective acyltransferase from Mycobacterium smegmatis (MsAcT). Acetylation of primary arylalkyl amines was achieved with a range of acetyl donors in biphasic systems within 1 hour and at room temperature. Vinyl acetate was the best donor which could be employed in the N-acetylation of a large range of primary amines in excellent yields (85–99%) after just 20 minutes. Other acyl donors (including formyl-, propionyl-, and butyryl-donors) were also efficiently employed in the biocatalytic N-acylation. Finally, the biocatalyst was tested in transamidation reactions using acetamide as acetyl donor in aqueous medium, reaching yields of 60–70%. This work expands the toolbox of preparative methods for the formation of N-acyl amides, describing a biocatalytic approach easy to accomplish under mild conditions in water. (Figure presented.).

Silica-supported polyphosphoric acid in the synthesis of 4-substituted tetrahydroisoquinoline derivatives

We report herein an application of an α-amidoalkylation reaction, as an alternative efficient synthesis of 4-aryl- and 4-methyl-1,2,3,4- tetrahydroisoquinoline derivatives. The amides required for this purpose would result from reaction of aminoacetaldehyde dimethylacetal with different substituted benzenes in polyphosphoric acid, followed by acylation of the obtained amines with different acid chlorides or sulfochlorides. We compared the cyclisation step using conventional (milieu of acetictrifluoracetic acid = 4:1) and solid supported reagents (SiO2/PPA), as recovered, regenerated and reused without loss of its activity catalyst. We found that in comparison to conventional methods, the yields of the reaction are greater and the reaction time is shorter.