2273-39-4

Basic information

• Product Name: 2-METHYL-2-(METHYLAMINO)PROPANENITRILE
• Synonyms: Propionitrile,2-methyl-2-(methylamino)- (6CI,7CI,8CI); 2-(Methylamino)-2-methylpropionitrile;2-Cyano-2-(methylamino)propane; 2-Methyl-2-(methylamino)propionitrile;2-Methylamino-2-cyanopropane; a,a-Dimethyl-N-sarcosinonitrile
• CAS NO: 2273-39-4
• Molecular Formula: C₅H₁₀N₂
• Molecular Weight: 98.15
• Mol File: 2273-39-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 168.3°Cat760mmHg
• Flash Point: 55.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.63mmHg at 25°C
• PKA: 4.77±0.20(Predicted)
• CAS DataBase Reference: 2-METHYL-2-(METHYLAMINO)PROPANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2-(METHYLAMINO)PROPANENITRILE(2273-39-4)
• EPA Substance Registry System: 2-METHYL-2-(METHYLAMINO)PROPANENITRILE(2273-39-4)

Safety Data

• Hazardous Substances Data: 2273-39-4(Hazardous Substances Data)

Usage

Uses

2-Methylamino-2-cyanopropane is used in the development of androgen receptor radioligands.

InChI:InChI=1/C5H10N2/c1-5(2,4-6)7-3/h7H,1-3H3/p+1

Upstream product

• 151-50-8 potassium cyanide 
• 67-64-1 acetone 
• 74-89-5 methylamine 
• 7732-18-5 water 
• 593-51-1 methylamine hydrochloride 
• 80102-31-4 imino-5 trimethyl-3,4,4 thiazolidine thione-2 
• 143-33-9 sodium cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 80102-30-3 3,4,4-trimethyl-5-methyliminothiazolidine-2-thione 
• 20513-25-1 5,5-dimethylimidazolidine-2,4-dithione 
• 80102-31-4 imino-5 trimethyl-3,4,4 thiazolidine thione-2 
• 80102-38-1 5-imino-3,4,4-trimethyl-thiazolidine-2-thione; compound with 5,5-dimethyl-imidazolidine-2,4-dithione 
• 19355-69-2 2-amino-2-cyanopropane 
• 127931-80-0 1,5,5-Trimethyl-3-(3-trifluoromethyl-phenyl)-imidazolidine-2,4-dione 
• 6407-34-7 methyl-1 ethylideneamine 
• 67-64-1 acetone 
• 74-89-5 methylamine 
• 116577-09-4 2,N²-dimethyl-propane-1,2-diamine 
• 242468-97-9 α-(methyl-p-toluoyl-amino)-isobutyric acid 
• 861597-66-2 α-(methyl-m-toluoyl-amino)-isobutyric acid 
• 409108-28-7 N-benzoyl-N-methyl-α-amino-2-methylpropionic acid 
• 793668-39-0 2-iodo-4-(3,4,4-trimethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-benzonitrile 

Relevant articles and documents

Carboxy beta-lactams by photochemical ring contraction.

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PYRAZOLAMIDE COMPOUND HAVING INSECTICIDAL ACTIVITY AND USE THEREOF

The present invention discloses a pyrazolamide compound of General Formula I having an insecticidal activity and an intermediate of General Formula II used to preparing the compound of General Formula I, wherein R1 is selected from chloro or CN

Mecanisme de la reaction de Bucherer-Bergs Comparaison avec l'hydratation basique des α-aminonitriles

The Bucherer-Bergs reaction provides an important tool for the synthesis of α-aminoacids and is the basis of an industrial process for producing methionine.The key compound is the α-aminonitrile 1 which leads to partial decomposition in carbonate buffer as well as in weakly basic aqueous media and to the equilibrated formation of the basic intermediate α-carboxy-aminonitrile 2a.The parameters which control the stability of 2a are summarised.These equlibria are established through an initial fast step which is then followed by the formation of the hydantoin 5a.At a constant pH this formation is first order in α-carboxyaminonitrile 2a via a 5-imino-2-oxazolidinone 3a and an α-isocyanatamide 4a.A comparison of the reactivity of 1 with that of the N-alkylated compouds 7 shows that the rate determining step of the hydantoin formation is the cyclisation of 2a at pH9.But at higher pH, the reaction is controlled by the fast partitioning of the cyclic intermediate 3a between the α-carboxyaminonitrile 2a and the isocyanatamide 4a.This study permits the direct comparison between two mechanism for the synthesis of the racemic α-aminoacids: the Bucherer-Bergs way and the catalytic hydratation of α-aminonitriles.It is clear that carbonic anhydre can be considered as a special carbonyl compound with respect to its reactivity towards α-aminonitriles.