2289-75-0

Basic information

• Product Name: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE
• Synonyms: IFLAB-BB F1920-0013;AURORA 5329;ASISCHEM D48929;AKOS BBS-00004664;4,5-DIMETHYL-THIAZOL-2-YLAMINE;4,5-DIMETHYL-1,3-THIAZOL-2-AMINE;2-Amino-4,5-dimethyl-1,3-thiazole;4,5-DIMETHYLTHIAZOL-2-AMINE
• CAS NO: 2289-75-0
• Molecular Formula: C₅H₈N₂S
• Molecular Weight: 128.2
• Product Categories: amine;pharmaceutical intermediate
• Mol File: 2289-75-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 66-69
• Boiling Point: 256.1 °C at 760 mmHg
• Flash Point: 108.7 °C
• Appearance: /
• Density: 1.198 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE(2289-75-0)
• EPA Substance Registry System: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE(2289-75-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 2289-75-0(Hazardous Substances Data)

Usage

General Description

4,5-Dimethyl-1,3-thiazol-2-amine, also known as dimethyldithiazolamine, is an organic compound with the molecular formula C5H10N2S. It is a pale yellow liquid with a fishy odor and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical is also known for its role as a corrosion inhibitor in industrial processes and as a nucleophile in organic reactions. It is considered to be toxic if ingested or inhaled in large quantities and can cause irritation to the skin and eyes. Furthermore, it is important to handle and store this chemical in a well-ventilated area and with proper protective equipment. Overall, 4,5-Dimethyl-1,3-thiazol-2-amine is a versatile compound with various applications in different industries.

InChI:InChI:1S/C5H8N2S/c1-3-4(2)8-5(6)7-3/h1-2H3,(H2,6,7)

Upstream product

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• 64-17-5 ethanol 
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• 44521-34-8 2-chloro-3-nitroso-butane 
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• 63752-08-9 (2-amino-4-methyl-thiazol-5-ylmethyl)-triphenyl-phosphonium; chloride 
• 814-75-5 3-bromo-butanone 
• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 

Downstream Products

• 74531-15-0 4,5-dimethylthiazole-2-carbaldehyde 
• 26188-50-1 2,3-dimethyl-6-phenyl-imidazo[2,1-b]thiazole 
• 850851-36-4 4,5-dimethyl-2-nitro-thiazole 
• 25968-26-7 6-(4-chlorophenyl)-2,3-dimethylimidazo<2,1-b>thiazole 
• 545367-05-3 N-acetyl-sulfanilic acid-(4,5-dimethyl-thiazol-2-ylamide) 
• 851531-44-7 6-(3,6-dimethoxy-2-nitro-phenyl)-2,3-dimethyl-imidazo[2,1-b]thiazole 
• 851531-51-6 6-(2,5-dimethoxy-4-nitro-phenyl)-2,3-dimethyl-imidazo[2,1-b]thiazole 
• 87669-10-1 7-hydroxy-2,3-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one 

Relevant articles and documents

Synthesis of 6-membered-ring fused thiazine-dicarboxylates and thiazole-pyrimidines via one-pot three-component reactions

A facile and efficient one-pot three-component reaction method for the synthesis of thiazine-dicarboxylates is reported. Reaction of an isocyanide and dialkyl acetylenedicarboxylate with 2-amino-4H-1,3-thiazin-4-one derivatives containing both an acidic proton and an internal nucleophile gave the products in good yields of 76–85%. The reactivity of dialkyl acetylenedicarboxylates was further tested in the synthesis of thiazole-pyrimidines where a two-component reaction of 2-aminothiazole with dialkyl acetylenedicarboxylates was successfully converted to a more efficient three-component reaction of a thiourea, α-haloketone and dialkyl acetylenedicarboxylate (DMAD/DEtAD) to give thiazole-pyrimidines in good yields of 70–91%.

Synthesis of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives

The reaction of 2-aminothiazoles with ethyl acetoacetate in acetic or polyphosphoric acid gave a series of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives which were nitrated with a mixture of nitric and sulfuric acid to 6-nitro-5H-[1,3]thiazolo[3,2-a]

One pot synthesis using supported reagents system KSCN/SiO 2-RNH3OAc/Al2O3: Synthesis of 2-aminothiazoles and N-allylthioureas

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH 3OAc/Al2O3, in which α-halo ketone reacts first KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO 2 and the product, allyl isothiocyanate, reacts with RNH 3OAc/Al2O3 to give N-allylthiourea.