57308-65-3

Upstream product

• 333-20-0 potassium thioacyanate 
• 4091-39-8 3-chloro-2-butanone 
• 814-75-5 3-bromo-butanone 
• 1147550-11-5 ammonium thiocyanate 
• 78-93-3 butanone 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 5351-51-9 4,5-dimethyl-3H-thiazole-2-thione 
• 15865-94-8 4,5-dimethyl-N-phenylthiazol-2-amine 
• 101275-86-9 (4,5-dimethyl-thiazol-2-yl)-(4-tert-pentyl-phenyl)-amine 
• 98484-92-5 (4,5-dimethylthiazol-2-yl)hydrazine 
• 98337-34-9 ethyl-(4,5-dimethyl-thiazol-2-yl)-amine 
• 100142-85-6 4-(4,5-dimethyl-thiazol-2-ylamino)-benzoic acid 
• 56355-41-0 2-chloro-4,5-dimethyl-1,3-thiazole 
• 2289-75-0 4,5-dimethyl-1,3-thiazole-2-amine 
• 100143-34-8 5-(4,5-dimethyl-thiazol-2-ylamino)-2-hydroxy-benzoic acid 
• 5351-51-9 4,5-dimethylthiazole-2-thiol 
• 208396-25-2 phenyl-(3,4,5-trimethyl-3H-thiazol-2-ylidene)-amine 
• 1163277-52-8 3-(4-chlorophenyl)-4,5-dimethyl-1,3-thiazol-2(3H)-imine hydrochloride 

Relevant academic research and scientific papers

Synthesis and leukemia cell growth inhibition of a series of 1,3-dithiazolylbenzene derivatives

By a slightly modified Hantzsch thiazole synthesis either 1,3-bis[(thiazol-2-yl)amino]benzene derivatives 2 or 1,3-bis[2-iminothiazol- 3(2H)-yl]benzene derivatives 3 were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds 2a-2d and 3a-3d were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV-2.

α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen

A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.

NBS or DEAD as effective reagents in α-thiocyanation of enolizable ketones with ammonium thiocyanate

Ketones possessing α-hydrogen undergo smooth thiocyanation with ammonium thiocyanate in the presence of N-bromosuccinimide (NBS) at room temperature in acetonitrile under neutral conditions to produce the corresponding α-ketothiocyanates in excellent yiel

Synthesis of novel N-thiazolo-1,3-oxathiol-2-imines from α-haloketones using potassium thiocyanate-silica gel

Novel N-thiazolo-1,3-oxathiol-2-imines are synthesized by reaction of a-haloketones with potassium thiocyanate-silica gel. It is thought that the reaction occurs through conversion of the α-haloketone into the corresponding thiocyanate which then undergoes acid-catalyzed intramolecular cyclization to yield a cationic intermediate. Subsequent reaction of this intermediate with another molecule of the α-thiocyanatoketone and a second cyclization then gives the N-thiazolo-1,3-oxathiol-2-imine. Georg Thieme Verlag Stuttgart - New York.

Expedient synthesis of N-substituted 2-aminothiazoles

The reaction of α-halo ketones 1 with potassium thiocyanate and amines 3 offers the advantage of an efficient one-pot synthesis of the title compounds 4 from readily available starting materials.