23289-10-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE is used as a building block for the synthesis of biologically active molecules due to its unique chemical structure. It contributes to the development of new pharmaceutical agents with potential medicinal properties, making it a key component in drug discovery and design.
Used in Materials Science:
In the field of materials science, 2-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE is utilized in the development of new materials and polymers with specific properties. Its incorporation into these materials can lead to the creation of advanced polymers with tailored characteristics for various applications, showcasing its versatility and potential in material innovation.

InChI:InChI=1/C8H5ClN2O/c9-7-3-1-6(2-4-7)8-11-10-5-12-8/h1-5H

Upstream product

• 1895-39-2 sodium chlorodifluoroacetate 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 106970-98-3 3-(4-chlorophenyl)-3-oxopropionic acid tert-butyl ester 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 
• 68496-88-8 ethyl 5-(4-chlorophenyl)-1,3,4-oxadiazole-2-carboxylate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 74-11-3 para-chlorobenzoic acid 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 53170-28-8 triethyl orthoformate 
• 149-73-5 trimethyl orthoformate 
• 73789-56-7 N-isocyaniminotriphenylphosphorane 

Downstream Products

• 29207-86-1 4-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]morpholine 
• 500300-14-1 2-(4-chlorophenyl)-5-(naphthalen-1-yl)-1,3,4-oxadiazole 
• 1350919-94-6 2-(4-chlorophenyl)-5-[(E)-2-phenylvinyl]-1,3,4-oxadiazole 
• 1350919-99-1 (E)-2-(2-(biphenyl-4-yl)vinyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole 
• 52596-95-9 2-(4-chlorophenyl)-5-(4-methylphenyl)-1,3,4-oxadiazole 
• 23766-28-1 5-(4-chlorophenyl)-1,3,4-oxadiazole-2-thiol 
• 1374348-19-2 2-(4-chlorophenyl)-5-((4-fluorophenyl)ethynyl)-1,3,4-oxadiazole 
• 1374348-20-5 2-(4-chlorophenyl)-5-(thiophen-2-ylethynyl)-1,3,4-oxadiazole 
• 1632156-30-9 (5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)(phenyl)methanone 
• 1874-43-7 2-(4-chlorophenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant academic research and scientific papers

The reaction of (N-isocyanimino)triphenylphosphorane with benzoic acid derivatives: a novel synthesis of 2-aryl-1,3,4-oxadiazole derivatives

The reactions of benzoic acid derivatives with (N-isocyanimino)triphenylphosphorane proceed smoothly at room temperature to afford 2-aryl-1,3,4-oxadiazoles in high yields.

Ligand-Enabled Palladium-Catalyzed Through-Space C?H Bond Activation via a Carbopalladation/1,4-Pd Migration/C?H Functionalization Sequence

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp2)?C(sp2) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provi

[4u202f+u202f1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME

The present specification provides a compound represented by chemical formula 1 and an organic light emitting device including the same. The compound may improve lifespan characteristics of the organic light emitting device.

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME

The present specification provides a compound represented by chemical formula 1 and an organic light emitting device including the same. The compound may improve lifespan characteristics of the organic light emitting device.

Functionalization of 1,3,4-Oxadiazoles and 1,2,4-Triazoles via Selective Zincation or Magnesiation Using 2,2,6,6-Tetramethylpiperidyl Bases

We report the metalation of the 1,3,4-oxadiazole and 1,2,4-triazole scaffolds via regioselective zincation or magnesiation using the TMP bases (TMP = 2,2,6,6-tetramethylpiperidyl) TMP2Zn·2LiCl, TMP2Zn·2MgCl2·2LiCl, TMPMgCl

Method for constructing 2-(4-chlorphenyl)-1,3,4-oxadiazole in one step by using DMF as carbon source

The invention discloses a method for constructing 2-(4-chlorphenyl)-1,3,4-oxadiazole in one step by using DMF (N, N-dimethylformamide) as a carbon source. The method includes taking p-chlorphenyl hydrazide as a reaction raw material, and taking DMF (N, N-

DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process features the short reaction time and can be safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggest that the source of CH is from the N-methyl group of DMF. (Figure presented.).

Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions

A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3

Synthesis of the 1,3,4-Oxadiazole Core through Thermolysis of Geminal Diazides

The thermolysis of geminal diazides derived from acylacetate compounds is an efficient tool for the rapid construction of the 1,3,4-oxadiazole core. While a broad range of ethyl esters undergoes smooth transformation to the desired heterocycles that contain the ester moiety in moderate to high yields, the analogous tert-butyl esters give rise to the oxadiazoles with acyl groups, presumably through a pathway of decarboxylation followed by a new acyl transfer.