93986-11-9

Basic information

• Product Name: 4-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]phenyl methyl ether
• Synonyms: 4-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]phenyl methyl ether;2-(4-chlorophenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole
• CAS NO: 93986-11-9
• Molecular Formula: C₁₅H₁₁ClN₂O₂
• Molecular Weight: 286.71304
• Mol File: 93986-11-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]phenyl methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]phenyl methyl ether(93986-11-9)
• EPA Substance Registry System: 4-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]phenyl methyl ether(93986-11-9)

Safety Data

• Hazardous Substances Data: 93986-11-9(Hazardous Substances Data)

Upstream product

• 536-40-3 4-chlorobenzoic acid hydrazide 
• 104-88-1 4-chlorobenzaldehyde 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 51771-22-3 C₁₅H₁₃ClN₂O₂ 
• 829-35-6 2-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 23289-10-3 2-(4-chlorophenyl)-1,3,4-oxadiazole 
• 696-62-8 para-iodoanisole 
• 51771-28-9 4-Chloro-benzoic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 123-11-5 4-methoxy-benzaldehyde 
• 94025-91-9 4-methoxy-benzoic acid N'-(4-chloro-benzoyl)-hydrazide 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 16687-61-9 5-(4-chlorophenyl)tetrazole 

Relevant articles and documents

Photocatalyzed facile synthesis of 2,5-diaryl 1,3,4-oxadiazoles with polyaniline-?g-C3N4-TiO2 composite under visible light

PANI (polyaniline)-g-C3N4-TiO2 composite was prepared and found to be efficient for the synthesis of 2,5-diaryl 1,3,4-oxadiazoles under visible light. This reaction involved decarboxylation and cyclization from α-keto acids with acylhydrazines, and a broad scope of substrates were tolerated to provide the desired products in moderate to good yields. Control experiments indicated that a radical pathway was involved in the present photocatalytic reaction and a synergistic effect may exist in the ternary composite. Moreover, this semiconductor photocatalyst could be readily recovered and showed good reusability with only slight decrease in the catalytic activity after six consecutive runs.

Palladium-Catalyzed Aminocarbonylation Reaction to Access 1,3,4-Oxadiazoles using Chloroform as the Carbon Monoxide Source

A palladium-catalyzed aminocarbonylation reaction of aryl halides with chloroform and tetrazoles has been developed, where chloroform was employed as the carbon monoxide (CO) source in the presence of cesium hydroxide. The in situ generated N-acylated tetrazoles were unstable and easily decomposed to afford 2,5-disubstituted 1,3,4-oxadiazoles. A wide range of tetrazoles and aryl halides reacted smoothly under the optimized reaction conditions to give the corresponding products in moderate to good yields.

In situ generated cetyltrimethylammonium bisulphate in choline chloride-urea deep eutectic solvent: A novel catalytic system for one pot synthesis of 1,3,4-oxadiazole

Cetyltrimethylammonium bisulphate ([CTA]HSO4) catalysed one pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles from carboxylic acid and acid hydrazide in biodegradable deep eutectic solvent is investigated. [CTA]HSO 4 is generated in situ from cetyltrimethylammonium peroxodisulphate. Cyclization of diacylhydrazide using [CTA]HSO4 gives best alternative to traditional dehydration agents. Its remarkable features include a milder procedure, simplicity in workup and purification, good to excellent yields of products, use of inexpensive, recyclable reagents, and eco-friendly aspects by avoiding toxic catalysts/reagents and solvents. Graphical Abstract: [Figure not available: see fulltext.].