23825-35-6

Basic information

• Product Name: Benzamide,N,N-bis(phenylmethyl)-
• Synonyms: Benzamide,N,N-dibenzyl- (7CI,8CI); N,N-Dibenzylbenzamide; NSC 406284
• CAS NO: 23825-35-6
• Molecular Formula: C₂₁H₁₉NO
• Molecular Weight: 301.3817
• Mol File: 23825-35-6.mol
• Article Data: 95

Chemical Properties

• Boiling Point: 493.2°Cat760mmHg
• Flash Point: 232.1°C
• Density: 1.132g/cm³
• CAS DataBase Reference: Benzamide,N,N-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide,N,N-bis(phenylmethyl)-(23825-35-6)
• EPA Substance Registry System: Benzamide,N,N-bis(phenylmethyl)-(23825-35-6)

Safety Data

• Hazardous Substances Data: 23825-35-6(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 67-66-3 chloroform 
• 103-49-1 dibenzylamine 
• 620-40-6 tribenzylamine 
• 98-07-7 Benzotrichlorid 
• 25370-09-6 dibenzylcarbamyl chloride 
• 98-80-6 phenylboronic acid 
• 100-39-0 benzyl bromide 
• 55-21-0 benzamide 
• 848417-68-5 3,6-dibenzoyloxy-1,2-pyridazine 
• 478491-35-9 N-benzoyl-N-(6-cyano-1,3-dimethyl-2,4-dioxo-5-o-tolyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidin-7-yl)-benzamide 
• 100-44-7 benzyl chloride 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 

Downstream Products

• 1193731-81-5 (S)-3-(4-nitrophenyl)isobenzofuran-1(3H)-one 
• 7673-07-6 tribenzylamine hydrochloride 
• 620-40-6 tribenzylamine 
• 103-49-1 dibenzylamine 
• 1618672-88-0 dimethyl 2-((N,N-dibenzylamino)(phenyl)methylene)malonate 
• 65-85-0 benzoic acid 
• 15429-13-7 N,N-dibenzyl-1-phenylpropan-1-amine 
• 1228469-03-1 N,N-dibenzyl-1,2,3-triphenylpropan-2-amine 
• 451-40-1 phenyl benzyl ketone 
• 1485-70-7 N-benzylbenzamide 

Relevant articles and documents

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

DIVERSITY-ORIENTED SYNTHESIS OF N,N,O-TRISUBSTITUTED HYDROXYLAMINES FROM ALCOHOLS AND AMINES BY N-O BOND FORMATION

In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

UV-Light-Induced N-Acylation of Amines with α-Diketones

Herein, we develop a mild method for N-acylation of primary and secondary amines with α-diketones induced by ultraviolet (UV) light. Forty-six examples with various functional groups are explored at room temperature with irradiation by three 26 W UV lamps (350-380 nm). The yield reaches 97%. The gram scale experiment product yield is 76%. Moreover, this system can be applied to the synthesis of several amino acid derivatives. Mechanistic studies show that benzoin is generated in situ from benzil under UV irradiation.