24303-06-8

Basic information

• Product Name: N-(4-fluorophenyl)pyridine-3-carboxamide
• Synonyms: 3-pyridinecarboxamide, N-(4-fluorophenyl)-; N-(4-Fluorophenyl)nicotinamide
• CAS NO: 24303-06-8
• Molecular Formula: C₁₂H₉FN₂O
• Molecular Weight: 216.2111
• Mol File: 24303-06-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 264.2°C at 760 mmHg
• Flash Point: 113.6°C
• Density: 1.304g/cm³
• Vapor Pressure: 0.00983mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: N-(4-fluorophenyl)pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)pyridine-3-carboxamide(24303-06-8)
• EPA Substance Registry System: N-(4-fluorophenyl)pyridine-3-carboxamide(24303-06-8)

Safety Data

• Hazardous Substances Data: 24303-06-8(Hazardous Substances Data)

Upstream product

• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 371-40-4 4-fluoroaniline 
• 98-92-0 nicotinamide 
• 626-55-1 3-Bromopyridine 
• 13939-06-5 molybdenum hexacarbonyl 
• 1692-25-7 3-pyridylboronic acid 
• 350-46-9 4-Fluoronitrobenzene 
• 3796-23-4 3-(trifluoromethyl)pyridine 
• 59-67-6 nicotinic acid 
• 10400-19-8 3-pyridinecarbonyl chloride 

Downstream Products

• 1607469-33-9 fac-[Re(CO)₃(2,2′-bipyridine)(N-(4-fluorophenyl)nicotinamide)][OTf] 

Relevant articles and documents

Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases

We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C?F bond activation, accompanied with utilisation of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF3 group into other functionalities. (Figure presented.).

Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), DFT calculations, the Molecular electrostatic potential (MEP) and ADME were investigated.

Efficient conversion of acids and esters to amides and transamidation of primary amides using OSU-6

OSU-6, an MCM-41 type hexagonal mesoporous silica with strong Bronsted acid properties, has been used to promote the high-yield conversion of carboxylic acids and esters to carboxamides as well as transamidations of primary amides in a one-pot solventless approach. A metal-free heterogeneous catalyst that promotes all of these processes has not been previously reported. OSU-6 enables these transformations to proceed in shorter times and at lower temperatures for a broad range of substrates. An added benefit is that the catalyst can be recycled and reused multiple times without significant loss of activity.