24332-64-7

Upstream product

• 65-85-0 benzoic acid 
• 652-67-5 Isosorbide 
• 100-52-7 benzaldehyde 
• 641-74-7 1,4:3,6-dianhydro-D-mannitol 
• 98-88-4 benzoyl chloride 
• 28948-16-5 (3R,3aS_.6R,6aS)hexahydrofuro[3,2-b]furan-3,6-diol 
• 641-74-7 1,4:3,6-dianhydro-L-iditol 
• 50-70-4 D-sorbitol 
• 7625-23-2 3,6-anhydro-D-glucose 
• 53648-56-9 3,6-anhydro-D-glucitol 
• 7226-27-9 1,6-di-O-benzoyl-D-mannitol 
• 69-65-8 mannitol 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 67-64-1 acetone 

Downstream Products

• 24808-19-3 (3S,3aS,6S,6aS)-6-[(methylsulfonyl)oxy]hexahydrofuro[3,2-b]furan-3-yl methanesulfonate 

Relevant academic research and scientific papers

Oxidative NHC-Catalysis as Organocatalytic Platform for the Synthesis of Polyester Oligomers by Step-Growth Polymerization

The application of N-heterocyclic carbene (NHC) catalysis to the polycondensation of diols and dialdehydes under oxidative conditions is herein presented for the synthesis of polyesters using fossil-based (ethylene glycol, phthalaldehydes) and bio-based (

Visible-Light Photocatalysis Employing Dye-Sensitized Semiconductor: Selective Aerobic Oxidation of Benzyl Ethers

The aerobic oxidation is an attractive approach toward environmentally benign synthesis of fine chemicals. In addition, dye-sensitized semiconductors are underdeveloped photocatalysts for selective organic synthesis. With the aid of catalytic eosin Y-sensitized titanium dioxide, we have developed efficient aerobic photooxidation of benzyl ethers to benzoates, featuring low cost, high atom economy, broad substrate scope, and user-friendly setup. Furthermore, preliminary mechanistic studies established that the reaction pathway likely entails a photoinduced, radical-based two-step process via an isolable peroxide intermediate.

Preparation method of dicarboxylic isosorbide

The invention provides a preparation method of a dicarboxylic isosorbide. According to the preparation method, sorbitol is taken as a raw material, 0.5 to 48h of dehydration is carried out in the presence of a dehydration catalyst at N2 atmosphere at 100 to 180 DEG C, a monoprotic acid and an esterification catalyst are added, reaction temperature is increased to 185 to 250 DEG C for 0.5 to 48h of esterification, and reduced pressure distillation is carried out so as to obtain the dicarboxylic isosorbide product. The dicarboxylic isosorbide is a novel biomass-based plasticizer, can be used for replacing phthalic acid ester in production of polyvinyl chloride products such as agricultural plastic mulching film. Product yield of the preparation method is high; production separation is convenient; the preparation method is friendly to the environment; and application prospect is promising.

Preparation method of dicarboxylic acid isosorbide ester plasticizer

The invention provides a preparation method of a dicarboxylic acid isosorbide ester plasticizer. According to the method, isosorbide and monobasic acid serve as raw materials, and an esterification reaction is carried out for 0.5-48 h at the temperature of 65-250 DEG C under the catalytic effect. Dicarboxylic acid isosorbide ester is obtained through reduced pressure distillation. Dicarboxylic acid isosorbide ester is a non-toxic plasticizer, and can replace phthalic acid ester to be used for production of electric wire and cable sheaths, agricultural plastic mulching films and other polyvinyl chloride products. The product prepared through the method is high in yield, easy to separate and environmentally friendly, and has good application prospects.

Sustainable polyacetals from isohexides

A single step synthetic protocol to access a small family of renewable diacetals was established. The resultant chiral diacetals are valuable building blocks in pharmaceuticals and materials science. To demonstrate their synthetic competence, isohexide-diacetals (2a-c) were subjected to acetal metathesis polymerization and the corresponding polymers (poly2a-c) were isolated as white solids with molecular weights in the range 3200-27 600 (g mol-1). The semi-crystalline polymers displayed glass transition temperatures between 38-65 °C and melting temperatures in the range 103-156 °C. The isohexide derived polyacetals are stable under practical washing and rinsing conditions but degrade in slightly acidic media. This journal is the Partner Organisations 2014.

NITRIC OXIDE DONOR COMPOUNDS

The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof : wherein A and A' are independently selected from the group consisting of H and -(X)s-Y with the proviso that at least one of A or A' is not H; wherein s is 0 or 1; X is selected from the group consisting of : -CO-, -COO-, -CONH- and -SO2- or (A); Y is straight or branched C1-C20 alkyl chain, preferably C1- C10 alkyl chain, substituted with one or two -ONO2; or C1-C6 alkylenoxy- C1-C5 alkyl wherein the alkyl group is substituted by one or two -ONO2 groups. The invention also provides novel compositions comprising at least one compound of the invention and at least one therapeutic agent.

ANGIOTENSIN II RECEPTOR ANTAGONISTS

A compound having the structure (I) wherein R is an angiotensin II receptor antagonist selected from the group consisting of (IIa)- (IIh); A is (Formula) wherein Rl and R2 are independently selected from the group consisting of hydrogen and C1-4 alkyl. Y is X0-Z wherein X0 is selected from the group consisting of: -O-, -O-CO-, -OCOO-, -OCONH- and -OSO2-; Z is a nitric oxide releasing moiety, or a pharmaceutically acceptable salt thereof.

D-Isomannide in synthesis: Asymmetric Diels-Alder reactions with novel homochiral bis-imine Cu2+-catalysts

The synthesis of a set of novel homochiral bis-imine ligands 4 derived from D-isomannide 6, and their application in the Cu2+-catalyzed asymmetric Diels-Alder reaction of cyclopentadiene and N-tert-crotonoyloxazolidinone 1 is reported.

DIRECT REGIOSELECTIVE FORMATION OF POLYSUBSTITUTED TETRAHYDROFURANS FROM UNPROTECTED POLYOLS

The reaction of unprotected polyols (tetraols, pentitol and hexitol) with trimethyl orthobenzoate in CH2Cl2-MeOH afforded polysubstituted tetrahydrofurans in a one-pot synthesis.