93022-30-1

Basic information

• Product Name: 4-ACETOXYSTILBENE
• Synonyms: 4-STYRYLPHENYL ACETATE;4-ACETOXYSTILBENE;4-Stilbenol acetate;4-(2-Phenylethenyl)phenol 1-acetate
• CAS NO: 93022-30-1
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.28
• Product Categories: Stilbenes (substituted)
• Mol File: 93022-30-1.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ACETOXYSTILBENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETOXYSTILBENE(93022-30-1)
• EPA Substance Registry System: 4-ACETOXYSTILBENE(93022-30-1)

Safety Data

• Hazardous Substances Data: 93022-30-1(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 33527-94-5 4-acetoxyiodobenzene 
• 3839-46-1 stilben-4-ol 
• 75-36-5 acetyl chloride 
• 540-38-5 p-Iodophenol 
• 878-00-2 4-formylphenyl acetate 
• 1100-88-5 benzyltriphenylphosphonium chloride 
• 100-44-7 benzyl chloride 
• 108-86-1 bromobenzene 
• 2628-16-2 p-acetoxystyrene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 114-70-5 sodium phenylacetate 
• 879008-22-7 3c-(4-hydroxy-phenyl)-2-phenyl-acrylic acid 
• 51082-12-3 3-(4-acetoxy-phenyl)-2-phenyl-acrylic acid 

Downstream Products

• 6554-98-9 trans-4-Hydroxystilbene 
• 1357581-69-1 (trans-2,4-diphenylcyclobutane-1,3-diyl)dibenzene-4,1-diyl diacetate 
• 1357581-71-5 (cis-2,4-diphenylcyclobutane-1,3-diyl)dibenzene-4,1-diyl diacetate 
• 1357581-66-8 [(1RS,2SR,3RS,4SR)-3,4-diphenylcyclobutane-1,2-diyl]dibenzene-4,1-diyl diacetate 
• 674368-06-0 4-[(Z)-2-phenylethenyl]phenyl acetate 

Relevant articles and documents

METHODS OF ARENE ALKENYLATION

The present disclosure provides for a rhodium-catalyzed oxidative arene alkenylation from arenes and styrenes to prepare stilbene and stilbene derivatives. For example, the present disclosure provides for method of making arenes or substituted arenes, in particular stilbene and stilbene derivatives, from a reaction of an optionally substituted arene and/or optionally substituted styrene. The reaction includes a Rh catalyst or Rh pre-catalyst material and an oxidant, where the Rh catalyst or Rh catalyst formed Rh pre-catalyst material selectively functionalizes CH bond on the arene compound (e.g., benzene or substituted benzene).

Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells

Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability.

A nitrogen and sulphur functionalized graphene oxide-palladium nanoparticle hybrid catalyst for an efficient Heck coupling

A nanocomposite comprised of Pd nanoparticles supported on chemically modified graphene (CMG) has been fabricated. Morphological and chemical characterization of the CMG-PdNP heterostructure has been carried out using PXRD, FTIR, Raman, XPS, TEM, SEM, EDX, and ICP-MS studies. The material contains 25.93 wt% of Pd(0) nanoparticles, with a diameter of 10-20 nm, well-dispersed on highly reduced graphene oxide containing a C/O ratio of 5.48. The efficacy of the CMG-PdNP system as a catalyst towards Heck cross-coupling with a variety of functionalized substrates has been demonstrated. Functionalization of reduced graphene oxide with heteroatoms like sulfur and nitrogen enhanced its dispersibility in organic solvents, and helped in stabilizing the active palladium species by acting as a ligand. The CMG-Pd composite exhibited an excellent catalytic activity with a substantially low catalytic loading (0.02 mol%), and the activity sustainable up to three reaction cycles. The remarkable effect might be a manifestation of N and S coordination to Pd, facilitating a high degree of dispersion and stabilization of Pd NPs onto the graphene surface.