769-59-5

Basic information

• Product Name: 3-phenylbutan-2-one
• Synonyms: 3-phenylbutan-2-one;1-Methyl-1-phenyl-2-propanone
• CAS NO: 769-59-5
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.20168
• EINECS: 212-212-2
• Mol File: 769-59-5.mol
• Article Data: 89

Chemical Properties

• Boiling Point: 207.3 °C at 760 mmHg
• Flash Point: 80.8 °C
• Appearance: /
• Density: 0.967 g/cm³
• Vapor Pressure: 0.227mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-phenylbutan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylbutan-2-one(769-59-5)
• EPA Substance Registry System: 3-phenylbutan-2-one(769-59-5)

Safety Data

• Hazardous Substances Data: 769-59-5(Hazardous Substances Data)

Usage

General Description

3-phenylbutan-2-one, also known as phenylbutanone or P2P, is an organic compound with the molecular formula C10H12O. It is a ketone and a derivative of phenylbutane, featuring a phenyl group attached to the second carbon atom of the butanone chain. 3-phenylbutan-2-one is commonly used as a precursor in the illicit production of amphetamine and methamphetamine, as well as in the manufacture of pharmaceuticals and perfume fragrances. It has a sweet, floral scent and is often added to perfumes for its pleasant aroma. However, due to its potential for misuse in drug production, it is a controlled substance in many countries.

InChI:InChI=1/C10H12O/c1-8(9(2)11)10-6-4-3-5-7-10/h3-8H,1-2H3

Upstream product

• 32123-84-5 3-phenylbut-3-en-2-one 
• 10152-58-6 2,2-dimethyl-3-phenyloxirane 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 20907-13-5 2-methyl-1-phenylpropane-1,2-diol 
• 767-99-7 2-phenylbut-2-ene 
• 1117-96-0 Diazoethan 
• 98-86-2 acetophenone 
• 108-86-1 bromobenzene 
• 6203-88-9 2-acetoxy-2-butene 
• 6249-81-6 3-phenyl-but-3-en-2-ol 
• 52089-32-4 3-phenyl-2-butanol 
• 90925-49-8 2-phenyl-2,3-butanediol 
• 100-42-5 styrene 
• 1206-36-6 diphenyltellurium dichloride 

Downstream Products

• 770-85-4 2-methyl-2-phenylbutan-3-one 
• 3280-08-8 2-methyl-3-phenyl-butan-2-ol 
• 18648-91-4 methyl-5 phenyl-4 dithiole-1,2 thione-3 
• 96455-78-6 3,6-dimethyl-6-phenyl-2-cyclohexenone 
• 40960-66-5 rac-(2R,3R)-3-phenylbutan-2-ol 
• 56907-39-2 rac-(2R,3S)-3-phenylbutan-2-ol 
• 2371-22-4 (+/-)-3-phenyl-butan-2-one semicarbazone 
• 34965-44-1 3-methyl-4-oxo-3-phenyl-valeric acid ethyl ester 
• 879125-12-9 3,4-dimethyl-3,4-diphenyl-2,5-hexanedione 
• 21906-17-2 3-phenyl-2-amino butane 
• 21906-17-2 1,2-trans-dimethyl-2-phenylethylamine 
• 21906-17-2 (dl)-threo-3-phenyl-2-butylamine 
• 79963-03-4 4-methyl-5-oxo-4-phenyl-hexanenitrile 
• 775-55-3 2-methyl-2-(1-phenyl-ethyl)-thiazolidine 

Relevant articles and documents

Oxidation of Nonactivated Anilines to Generate N-Aryl Nitrenoids

A low-temperature, protecting-group-free oxidation of 2-substituted anilines has been developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to construct functionalized N-heterocycles. The exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol percent Sc(OTf)3 triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrate the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity, and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones.

Visible-Light-Promoted Catalytic Ring-Opening Isomerization of 1,2-Disubstituted Cyclopropanols to Linear Ketones

Isomerization to linear ketones is a valuable transformation of 1,2-disubstituted cyclopropanols proceeding through radical intermediates. Despite simplicity of this reaction, the known protocol required stoichiometric amounts of both an oxidant and a reducing agent. In this article, we report a catalytic isomerization of 1,2-disubstituted cyclopropanols to linear ketones enabled by the photoredox catalytic system consisting of an acridinium photocatalyst and diphenyl disulfide under irradiation with blue LEDs.