26809-02-9

Usage

Chemical Description

Acetonitrile, water, and formic acid are solvents and reagents used in the metabolite profiling experiments.

Upstream product

• 186581-53-3 diazomethane 
• 74-90-8 hydrogen cyanide 
• 106-98-9 1-butylene 
• 187737-37-7 propene 
• 29443-39-8 methyl ethyl ketone hydrazone 
• 110-54-3 hexane 
• 625-77-4 N-acetylacetamide 
• 5459-42-7 N-1,1'3,3'-tetramethylbutylacetamide 
• 638-20-0 N,N'-diacetylurea 
• 860743-29-9 N-benzenesulfonyl-acetimidoyl chloride 
• 151-50-8 potassium cyanide 
• 562-54-9 potassium methyl sulfate 
• 60-35-5 acetamide 
• 127-09-3 sodium acetate 

Downstream Products

• 25664-08-8 4-hydroxymethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-ol 
• 100136-42-3 1-benzoyloxy-1H-pyridin-2-one-imine 
• 31909-58-7 2-furoylacetonitrile 
• 95262-09-2 3-[(4-bromophenyl)amino]-3-oxopropanoic acid 
• 6314-22-3 5-acetyl-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester 
• 6458-06-6 betaine 
• 6938-22-3 2,3-dihydrokhellinone 
• 96220-14-3 3-benzo[1,3]dioxol-5-yl-3-oxo-propionitrile 
• 855650-44-1 diazomalonic acid ethyl ester-p-toluidide 
• 109557-05-3 4-chloro-1-(2,6-dichloro-benzyl)-5-(2,4-dinitro-phenylsulfanyl)-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid amide 
• 855648-80-5 N-(4-bromo-phenyl)-2-diazo-malonamic acid ethyl ester 
• 860374-18-1 2-diazo-N-(4-methoxy-phenyl)-malonamic acid ethyl ester 
• 102159-37-5 1-(6-methoxy-3-veratryl-benzofuran-2-yl)-ethanone 

Relevant academic research and scientific papers

A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent

Investigations into the chemical origin of life have recently benefitted from a holistic approach in which possible atmospheric, organic, and inorganic systems chemistries are taken into consideration. In this way, we now report that a selective phosphate activating agent, namely methyl isocyanide, could plausibly have been produced from simple prebiotic feedstocks. We show that methyl isocyanide drives the conversion of nucleoside monophosphates to phosphorimidazolides under potentially prebiotic conditions and in excellent yields for the first time. Importantly, this chemistry allows for repeated reactivation cycles, a property long sought in nonenzymatic oligomerization studies. Further, as the isocyanide is released upon irradiation, the possibility of spatially and temporally controlled activation chemistry is thus raised.

Ethanol gas-phase ammoxidation to acetonitrile: The reactivity of supported vanadium oxide catalysts

New insights on the gas-phase ammoxidation of ethanol to acetonitrile over supported vanadia catalysts were obtained by means of reactivity experiments (in ethanol ammoxidation and oxidation) as well as in situ Raman and DRIFT spectroscopy. It was found that the rate-determining step during the redox process depends on the support type. In the case of V2O5/ZrO2, the V oxidation state under reaction conditions is closer to V5+, whereas with V2O5/TiO2, the reduction of V5+ is faster than the re-oxidation of the corresponding reduced V species by O2; thus, the V oxidation state under steady state conditions is lower than for V2O5/ZrO2. In the latter catalyst, the more oxidized V species is responsible for ammonia activation and reaction with the intermediate acetaldehyde, leading in the end to a better acetonitrile yield than with V2O5/TiO2. It was also found that V2O5/ZrO2 is more selective to acetaldehyde than V2O5/TiO2. With the former catalyst, ethanol is able to reduce V2O5 only to a limited extent. Conversely, V2O5/TiO2 is readily reduced by ethanol but this reduced V species is responsible for an unselective oxidation of the alcohol, giving more CO and CO2.

Interactions of the aromatic cavity of rigid calix[4]arene cone conformers with acid CH3 and CH2 containing guests in apolar solvents

The effect of the acidity of CH groups within the guests on the binding ability of the aromatic cavity of rigid cone conformers of p-tert-butylcalix[4]arene toward guests containing acid CH3 and CH2 groups have been investigated in a

Product selectivity controlled by manganese oxide crystals in catalytic ammoxidation

The performances of heterogeneous catalysts can be effectively tuned by changing the catalyst structures. Here we report a controllable nitrile synthesis from alcohol ammoxidation, where the nitrile hydration side reaction could be efficiently prevented by changing the manganese oxide catalysts. α-Mn2O3 based catalysts are highly selective for nitrile synthesis, but MnO2-based catalysts including α, β, γ, and δ phases favour the amide production from tandem ammoxidation and hydration steps. Multiple structural, kinetic, and spectroscopic investigations reveal that water decomposition is hindered on α-Mn2O3, thus to switch off the nitrile hydration. In addition, the selectivity-control feature of manganese oxide catalysts is mainly related to their crystalline nature rather than oxide morphology, although the morphological issue is usually regarded as a crucial factor in many reactions.

PROCESS FOR PRODUCING METHACRYLIC ACID OR METHACRYLIC ACID ESTERS

The present invention relates to a process for producing methacrylic acid or methacrylic acid esters. The present invention is directed to a new process for the production of methacrylic acid or alkyl methacrylate starting from Acrolein, which is available from glycerol or propane.

PRODUCTION OF ACETONITRILE AND/OR HYDROGEN CYANIDE FROM AMMONIA AND METHANOL

The invention relates to a process for producing a product gas comprising acetonitrile and/or hydrogen cyanide from a feed stream comprising ammonia and methanol over a solid catalyst comprising a support, a first metal and a second metal on the support, wherein the first metal and the second metal are in the form of a chemical compound, wherein the first metal is Fe, Ru or Co and the second metal is Sn, Zn, or Ge. The pressure is ambient pressure or higher and the temperature lies in a range from about 400° C. to about 700° C. Thus, the process for producing acetonitrile and/or hydrogen cyanide from ammonia and methanol may be catalyzed by a single catalyst and may be carried out in a single reactor. The invention also relates to a catalyst, a method for activating a catalyst and use of a catalyst for catalysing production of acetonitrile and/or hydrogen cyanide from ammonia and methanol.

Transition-metal-free addition reaction for the synthesis of 3-(aminobenzylidene/aminoalkylidene)indolin-2-ones and its synthetic applications

A novel and efficient transition-metal-free approach for the exclusive synthesis of Z-3-(aminobenzylidene/aminoalkylidene)indolin-2-ones in high yield from 2-oxindole and aryl/alkyl nitrile in the presence of LiOtBu and 2,2′-bipyridine system is described. In addition, we disclosed a new approach towards the metal-free fluorination using selectfluor and the C=C bond cleavage using CuI and environmentally benign O2.

Method of preparation of ethylamine or acetonitrile by reductive amination of ethanol

The present invention relates to a catalyst for manufacturing ethylamine and a method for manufacturing the same. More specifically, the present invention relates to: a nickel-supported catalyst for manufacturing ethylamine or acetonitrile which has impregnated nickel on a supporter as a catalyst capable of efficiently manufacturing ethylamine or acetonitrile at a normal pressure or lower by reacting ethanol with ammonia, a method for manufacturing the same, and a method for manufacturing ethylamine using the same.COPYRIGHT KIPO 2019

ZEOLITE CATALYST

The present disclosure relates to the preparation of pyridine derivatives, such as α-picoline or α-parvoline, and catalysts useful for the selective preparation of such pyridine derivatives. Particularly, the present disclosure relates to the selective preparation of certain pyridine derivative using dealuminated zeolite catalysts.

New composite catalysts for the synthesis of acetonitrile from ethanol and ammonia, prepared using calcium aluminates (Talyum)

Experiments on direct synthesis of acetonitrile from ethanol, ammonia, and hydrogen at 513–573 K in the presence of new Cu-, Cu–Zn–(Zr)-, and Cu–Mg-containing composite catalysts prepared using calcium aluminates (Talyum, technical-grade calcium aluminate) were performed The following results were reached: ethanol conversion 96.0–99.0%, selectivity with respect to acetonitrile 99.0%, and acetonitrile output exceeding the reported level by a factor of 1.2–1.4. The new technology can be implemented in industry.