4904-55-6Relevant academic research and scientific papers
Alkylation-arylation method and application of olefin compound
-
Paragraph 0179-0181, (2021/06/22)
The invention discloses an alkyl-arylation method of an olefin compound. The method comprises the following steps: reacting a reaction system comprising a compound a as shown in a formula II, a compound b as shown in a formula III and a compound c as shown in a formula IV to prepare a compound I as shown in a formula I; wherein R1 is selected from one of alkyl, substituted alkyl, heteroaryl and substituted heteroaryl; Ar is selected from one of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R2 is selected from one of alkyl, substituted alkyl, heteroaryl and substituted heteroaryl. The invention further provides application of the method. According to the method provided by the invention, the cheap and easily available catalyst is adopted, the reaction condition is mild, the method is green and environment-friendly, the selectivity and yield of the product are relatively high, a simple and effective method is provided for the field of organic synthesis to obtain the expensive alkyl harmonic diaryl compound, and the method has wide research value and industrial application prospect.
Cu-Catalyzed Alkylarylation of Vinylarenes with Masked Alkyl Electrophiles
Zhu, Xiaotao,Su, Muqiao,Zhang, Qi,Li, Yajun,Bao, Hongli
supporting information, p. 620 - 625 (2020/01/02)
A Cu-catalyzed synthesis of a range of value-Added 1,1-diarylalkanes by radical alkylarylation of vinylarenes with alkyl peroxides as masked alkyl electrophiles is reported. The reaction features broad substrate scope, good functional group tolerance, and mild reaction conditions. Various bioactive molecules and key pharmaceutical intermediates have been easily synthesized by this method, demonstrating its synthetic value.
Radical alkylation of C(sp3)-H bonds with diacyl peroxides under catalyst-free conditions
Tian, Hao,Xu, Wentao,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 14813 - 14816 (2019/12/24)
Herein, we describe a protocol for alkylation reactions of C(sp3)-H bonds with diacyl peroxides by means of a process involving cross-coupling between an alkyl radical and an α-Aminoalkyl radical. The mild, catalyst-And additive-free conditions make this protocol superior to previously reported C(sp3)-H alkylation strategies. The protocol was applied to 1,2,3,4-Tetrahydroisoquinolines and a tetrahydro-β-carboline derivative and could be carried out on a gram scale, indicating its utility for the alkylation of late-stage synthetic intermediates.
Iron-Catalyzed Regioselective Decarboxylative Alkylation of Coumarins and Chromones with Alkyl Diacyl Peroxides
Jin, Can,Sun, Bin,Xu, Tengwei,Yan, Zhiyang,Zhang, Xun
supporting information, p. 1585 - 1591 (2019/08/07)
A facile iron-catalyzed decarboxylative radical coupling of alkyl diacyl peroxides with coumarins or chromones has been developed, affording a highly efficient approach to synthesize a variety of α-alkylated coumarins and β-alkylated chromones. The reaction proceeded smoothly without adding any ligand or additive and provided the corresponding products containing a wide scope of functional groups in moderate to excellent yields. This protocol was highlighted by its high regioselectivity, readily available starting materials, and operational simplicity.
Copper-Catalyzed Decarboxylative Alkylation of Terminal Alkynes
Ye, Changqing,Li, Yajun,Bao, Hongli
supporting information, p. 3720 - 3724 (2017/09/18)
A copper-catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C(sp3)?C(sp) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered the alkylated internal alkynes with good to high performances. Mechanism studies suggested that this reaction involves a free radical pathway. (Figure presented.).
Process for preparing peroxides using mixed anhydrides
-
, (2008/06/13)
The invention relates to a process for the preparation of a peracid, perester or diacylperoxide and is characterized in that a mixed anhydride of formula R1[C(O)OC(O)OR2]nor [R3C(O)OC(O)O]pR4/su
DEPLACEMENTS HOMOLYTIQUES INTRAMOLECULAIRES-16-DECOMPOSITION DES PEROXYDES ET PERESTERS INSATURES PAR LES RADICAUX CYCLOHEXYLE ISSUS DE DERIVES PEROXIDIQUES DE L'ACIDE CYCLOHEXANECARBOXYLIQUE
Bourgeois, M. J.,Montaudon, E.,Maillard, B.
, p. 255 - 262 (2007/10/02)
Thermolyses of dicyclohexyl carbonyl peroxide have been performed in organic solutions of t-butyl pent-4-enyl peroxide or t-butyl perpent-4-enoate in order to study the induced decomposition by cyclohexyl radicals of these peroxides.Induced decomposition of cyclohexylcarbonyl pent-4-enoyl peroxide and pent-4-enyl cyclohexylpercarboxylate has also been studied.In the decomposition of these compounds, SHi reaction of an acyloxy radical is involved which is, to our knowledge, the first example of such reaction with a perester.
