27349-35-5Relevant articles and documents
Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives
Polkam, Naveen,Ramaswamy, Venkat Ragavan,Rayam, Parsharamulu,Allaka, Tejeswara Rao,Anantaraju, Hasitha Shilpa,Dharmarajan, Sriram,Perumal, Yogeeswari,Gandamalla, Durgaiah,Yellu, Narsimha Reddy,Balasubramanian, Sridhar,Anireddy, Jaya Shree
, p. 2562 - 2568 (2016)
A series of new edaravone derivatives 3-7 have been synthesized, characterised using various spectroscopic techniques and screened for their in vitro anti-cancer, antioxidant activities. Structure of 5d was further substantiated through single crystal X-ray diffraction. Among the tested, 5l exhibited pronounced activity against PC3 cancer cells. Compounds 5i, 5l, 7c showed potent activity against A549 cancer cells. Products 5k, 6, 7c demonstrated good antioxidant activity with MIC values of 18.60, 16.27, 16.07 μg/mL respectively. Further the reported analogues were also tested on normal HEK293T cells and displayed low to good safer profiles. Derivatives 5l and 7c have come out to be safer potent anticancer, antioxidant agents. Additionally, the target products were subjected to their molecular properties prediction and drug likeness by employing Molinspiration and Osiris property explorer toolkits. None of them violated Lipinski's boundaries classifying the title compounds as potential anticancer and antioxidant agents.
A regioselective synthesis of 5-pyrazolones and pyrazoles from phosphazenes derived from hydrazines and acetylenic esters
Palacios, Francisco,Ochoa De Retana, Ana M.,Pagalday, Jaione
, p. 14451 - 14458 (2007/10/03)
Efficient and regioselective syntheses of 1-phenyl-5-pyrazolones substituted with a phosphoranylidene group in the 3-position and of 3- alkoxycarbonyl-5-methoxy-1-phenyl pyrazoles are described. The key step is the formation of functionalized hydrazones b
