28584-90-9

Basic information

• Product Name: 1,5-Diphenyl-1,3,5-triazapentane-2,4-dione
• Synonyms: 1,5-Diphenyl-1,3,5-triazapentane-2,4-dione;1,5-Diphenylbiuret
• CAS NO: 28584-90-9
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.27
• Mol File: 28584-90-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,5-Diphenyl-1,3,5-triazapentane-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Diphenyl-1,3,5-triazapentane-2,4-dione(28584-90-9)
• EPA Substance Registry System: 1,5-Diphenyl-1,3,5-triazapentane-2,4-dione(28584-90-9)

Safety Data

• Hazardous Substances Data: 28584-90-9(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 64-10-8 phenyl carbamate 
• 857609-05-3 4-methyl-4-(2,4,5,5-tetrachloro-1-methyl-4,5-dihydro-1H-imidazol-4-yl)-allophanoyl chloride 
• 62-53-3 aniline 
• 71-43-2 benzene 
• 103-71-9 phenyl isocyanate 
• 108-19-0 BIURET 
• 761-89-7 allophanic acid methyl ester 
• 626-36-8 ethyl allophanate 
• 6620-41-3 N,N’-bis(ethoxycarbonyl)urea 
• 13911-40-5 N-phenylbiuret 
• 7647-01-0 hydrogenchloride 
• 7664-41-7 ammonia 
• 1576-59-6 2-amino-5-bromobenzenesulfonic acid 

Downstream Products

• 103-71-9 phenyl isocyanate 
• 62-53-3 aniline 
• 102-07-8 bis(diphenyl)urea 
• 603-54-3 N,N-diphenylurea 

Relevant articles and documents

Synthesis of Biuret Derivatives as Potential HIV-1 Protease Inhibitors Using (LDHs-g-HMDI-Citric Acid), as a Green Recyclable Catalyst

In this study, a novel catalyst based on layered double hydroxides (LDHs) attached by hexamethylene-1,6-diisocyanate (HMDI) and citric acid (LDHs-g-HMDI-Citric acid) is reported and used to increase the yield of biurets synthesis. Biuret derivatives 5a–n were prepared by reaction of several phenyl allophanates (3a–d), which prepared from the reaction of phenyl chloroformate and urea derivatives (2a–d), with variously substituted amines (4a–g) in the presence of LDHs-g-HMDI-Citric acid as a reusable heterogeneous catalyst at reflux condition for 60–180 min. These biurets (5a–n) were evaluated for human immunodeficiency virus type-1 (HIV-1) protease inhibitory activity by HIV-1 p24 antigen ELISA kit and six of them (5n, 5i, 5j, 5 m, 5f, and 5a) showed moderate activity on HIV-1 virus with IC50 values ranging from 55 to 100 μM compared with the azidothymidine as the reference drug (IC50 = 0.11 μM). Results of the in vitro test and docking study were in good correlation.