28835-95-2Relevant academic research and scientific papers
Deracemization by enantioselective dehydrohalogenation. Synthesis of optically active compounds bearing a chiral axis.
Duhamel, L.,Ravard, A.,Plaquevent, J. C.,Ple, G.,Davoust, D.
, p. 787 - 797 (2007/10/02)
This work describes the deracemization of 4-tert-butyl and 4-methylcyclohexylidene acetic acids bearing a chiral axis.Enantioselective dehydrohalogenation of prochiral species by chiral lithium amides allowed us to obtain e.e. as high as 82percent.A mecha
A Minor Modification of Residue 1 in Potent Vasopressin Antagonists Dramatically Reduces Agonist Activity
Huffman, William F.,Albrightson-Winslow, Christine,Brickson, Bridget,Bryan, Heidemarie G.,Caldwell, Nancy,et al.
, p. 880 - 884 (2007/10/02)
arginine-vasopressin (SK&F 101926, 1), a potent in vivo and in vitro vasopressin V2 receptor antagonist, was recently tested in human volunteers and s
SYNTHESIS OF CYCLOHEXYLALIPHATIC ACIDS AND THEIR PHARMACOLOGICAL PROPERTIES
Kuchar, Miroslav,Brunova, Bohumila,Grimova, Jaroslava,Vanecek, Stanislav,Holubek, Jiri
, p. 2896 - 2908 (2007/10/02)
A series of substituted cyclohexylacetic acids I has been obtained by hydrogenation of the unsaturated analogues II and III.Esters of these analogues were prepared by the Horner-Wittig reaction of the corresponding cyclohexanones IV and/or 2-cyclohexenones V with triethyl phosphonoacetate.These esters were obtained in two isomeric forms (Z and E), differing in the double bond in the exo-position.The derivatives with a substituent in the 2-position exhibited a partial shift of the double bond to the cyclohexane ring; this shift was especially marked in the 2-phenyl derivative.With the acids I-III, activation of fibrinolysis was assessed by the hanging clot method; the anti-inflammatory effect was assessed by inhibition of two experimental model inflammations.The regression equation relating fibrinolytic capacity to lipophilicity was a quadratic one, the logarithm of optimum lipophilicity being log Popt = 5.55.A qualitative assessment of the anti-inflammatory effect in relation to lipophilicity suggests that log Popt is probably higher than with arylaliphatic acids.These acids seem to have an active site different from that of the acids I-III.
ELECTRON TRANSFER FROM METAL SURFACES. FORMATION OF LITHIUM AND GRIGNARD REAGENTS.
Walborsky, H. M.,Banks, R. Bruce
, p. 849 - 868 (2007/10/02)
Chiral (+)-(S)-4-methylcyclohexylidenebromomethane (1) has been prepared from (-)-(R)-4-methylcyclohexylideneacetic acid by a stereospecific bromodecarboxylation reaction.The reaction was shown to proceed with an overall inversion of configuration.The rea
