28987-44-2

Basic information

• Product Name: 2-ETHOXY-4-FLUORO-1-NITROBENZENE
• Synonyms: 2-ETHOXY-4-FLUORO-1-NITROBENZENE;2-Ethoxy-4-fluoronitrobenzene;2-Ethoxy-4-fluoronitrobenzene 98%;2-Ethoxy-4-fluoronitrobenzene98%;Benzene,2-ethoxy-4-fluoro-1-nitro-
• CAS NO: 28987-44-2
• Molecular Formula: C₈H₈FNO₃
• Molecular Weight: 185.1524232
• EINECS: 604-604-1
• Product Categories: blocks;FluoroCompounds;NitroCompounds
• Mol File: 28987-44-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 35-37
• Boiling Point: 261.5°Cat760mmHg
• Flash Point: 111.9°C
• Appearance: /
• Density: 1.268g/cm³
• Vapor Pressure: 0.0187mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-ETHOXY-4-FLUORO-1-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXY-4-FLUORO-1-NITROBENZENE(28987-44-2)
• EPA Substance Registry System: 2-ETHOXY-4-FLUORO-1-NITROBENZENE(28987-44-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 28987-44-2(Hazardous Substances Data)

Usage

General Description

2-ethoxy-4-fluoro-1-nitrobenzene is a chemical compound with the molecular formula C8H8FNO3. It is a yellow crystalline solid that is used in the production of pharmaceuticals, agrochemicals, and dyes. 2-ETHOXY-4-FLUORO-1-NITROBENZENE is known to have potential toxic and harmful effects on human health and the environment, and thus requires careful handling and disposal. It is also known to be a skin and eye irritant and may cause respiratory irritation if inhaled. Additionally, it may have harmful effects on aquatic life if released into the environment. Therefore, proper precautions and safety measures should be taken when handling this chemical.

InChI:InChI=1/C8H8FNO3/c1-2-13-8-5-6(9)3-4-7(8)10(11)12/h3-5H,2H2,1H3

Upstream product

• 446-36-6 5-fluoro-2-nitrophenol 
• 75-03-6 ethyl iodide 
• 74-96-4 ethyl bromide 
• 64-17-5 ethanol 
• 446-35-5 2,4-Difluoronitrobenzene 
• 1972-28-7 diethylazodicarboxylate 
• 75-89-8 2,2,2-trifluoroethanol 
• 141-52-6 sodium ethanolate 
• 917-58-8 potassium ethoxide 

Downstream Products

• 64635-54-7 3-ethoxy-4-nitrophenol 

Relevant articles and documents

Discovery and structure ? activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors

Internal tandem duplications of FLT3 (FLT3-ITD) occur in approximately 25% of all acute myeloid leukemia (AML) cases and confer a poor prognosis. Optimization of the screening hit 1 from our in-house compound library led to the discovery of a series of pyrazolo[1,5-a]pyrimidine derivatives as potent and selective FLT3-ITD inhibitors. Compounds 17 and 19 displayed potent FLT3-ITD activities both with IC50 values of 0.4 nM and excellent antiproliferative activities against AML cell lines. Especially, compounds 17 and 19 inhibited the quizartinib resistance- conferring mutations, FLT3D835Y, both with IC50 values of 0.3 nM. Moreover, western blot analysis indicated that compounds 17 and 19 potently inhibited the phosphorylation of FLT3 and attenuated downstream signaling in AML cells. These results indicated that pyrazolo[1,5-a]pyrimidine derivatives could be promising FLT3-ITD inhibitors for the treatment AML.

A class of FLT3 kinase inhibitors, preparation and application thereof

The invention relates to a class of FLT3 kinase inhibitors, preparation and application thereof, wherein specifically the compound has a structure represented by a formula (I), and all groups and substituents are defined in the specification. The invention also discloses a preparation method of the compound, and application of the compound in inhibition of FLT3.

PYRIMIDINE DERIVATIVE AND USE THEREOF

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.