2-Ethoxy-4-fluoro-1-nitrobenzene

Base Information

• Chemical Name: 2-Ethoxy-4-fluoro-1-nitrobenzene
• CAS No.: 28987-44-2
• Molecular Formula: C8H8 F N O3
• Molecular Weight: 185.155
• Hs Code.: 2909309090
• European Community (EC) Number: 800-958-7
• DSSTox Substance ID: DTXSID40512930
• Wikidata: Q82372382
• Mol file: 28987-44-2.mol

Synonyms:2-ethoxy-4-fluoro-1-nitrobenzene;28987-44-2;2-Ethoxy-4-fluoronitrobenzene;2-Ethoxy-4-fluoro-1-nitro-benzene;MFCD04115630;Benzene, 2-ethoxy-4-fluoro-1-nitro-;SCHEMBL310522;DTXSID40512930;LEMJFSSYFHTFFP-UHFFFAOYSA-N;4-fluoro-2-ethoxy-1-nitrobenzene;AKOS006229149;2-(ethyloxy)-4-fluoro-1-nitrobenzene;AT23047;BS-22192;SY185214;CS-0212162;EN300-72157;2-Ethoxy-4-fluoro-1-nitrobenzene, AldrichCPR;A819703

Chemical Property of 2-Ethoxy-4-fluoro-1-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.0187mmHg at 25°C
• Melting Point: 35-37
• Refractive Index: 1.516
• Boiling Point: 261.5°Cat760mmHg
• Flash Point: 111.9°C
• PSA: 55.05000
• Density: 1.268g/cm³
• LogP: 2.65580
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 185.04882128
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

97% ^*data from raw suppliers

2-Ethoxy-4-fluoro-1-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=CC(=C1)F)[N+](=O)[O-]

Technology Process of 2-Ethoxy-4-fluoro-1-nitrobenzene

There total 9 articles about 2-Ethoxy-4-fluoro-1-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-fluoro-2-nitrophenol (446-36-6) + ethyl iodide (75-03-6) → 5-fluoro-2-nitrophenyl ethyl ether (28987-44-2)

Guidance literature:

With potassium carbonate; In acetone; for 15h; Reflux;

Reference yield: 98.0%

ethyl bromide (74-96-4) + 5-fluoro-2-nitrophenol (446-36-6) → 5-fluoro-2-nitrophenyl ethyl ether (28987-44-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 37 ℃;

Reference yield: 95.0%

ethanol (64-17-5) + 2,4-Difluoronitrobenzene (446-35-5) → 5-fluoro-2-nitrophenyl ethyl ether (28987-44-2)

Guidance literature:

With caesium carbonate; Heating;

upstream raw materials:

2,4-Difluoronitrobenzene

potassium ethoxide

sodium ethanolate

2,2,2-trifluoroethanol

Downstream raw materials:

2-ethoxy-4-fluorobenzenamine

1-(3-ethoxy-4-nitrophenyl)-N,N-dimethylpiperidin-4-amine

2-(3-ethoxy-4-nitro-phenoxy)-N,N-dimethyl-ethanamine

1-(3-ethoxy-4-nitro-phenyl)-4-methyl-1,4-diazepane