29747-05-5

Upstream product

• 67-56-1 methanol 
• 614-44-8 benzoyloxyacetic acid 
• 96-35-5 glycolic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 96-32-2 bromoacetic acid methyl ester 
• 65-85-0 benzoic acid 
• 61985-23-7 methyl 1-imidazolecarboxylate 
• 108-59-8 malonic acid dimethyl ester 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 223429-13-8 (S)-1-oxohexan-2-yl benzoate 
• 64649-43-0 (aminocarbonyl)methyl benzoate 
• 532-32-1 sodium benzoate 
• 94465-43-7 2,5-bis-benzoyloxymethyl-furan 

Downstream Products

• 107940-22-7 2-Benzoyloxy-2-(trimethylsilyl)ethansaeure-methylester 
• 212517-18-5 Benzoic acid (Z)-2-dimethylamino-1-methoxycarbonyl-vinyl ester 
• 614-44-8 benzoyloxyacetic acid 

Relevant academic research and scientific papers

Temperature-controlled NaI-mediated α-oxybenzoylation or oxyacylation-decarboxylation reactions of dimethyl malonate with carboxylic acids

A NaI-mediated α-functionalization of dimethyl malonate and its derivatives with carboxylic acids has been developed. Two different reaction routes based on the same substrates and reaction conditions by simply altering the reaction temperature have been

Practical one-pot sequence for the asymmetric synthesis of 1,2 diols from primary alcohols

A practical one-pot three-step sequence is reported for the asymmetric synthesis of α-benzoyloxylated alcohols from primary alcohols. Good overall yields (36-52%) and enantioselectivities (91-94% e.e.) are obtained using a commercial organocatalyst in the key oxylation reaction. A simple modification in the protocol allows the formation of enantioenriched γ-benzoyloxylated α,β-unsaturated ester from alcohol. Synthetic utility has been harnessed to the easy preparation of (-)-γ-octalactone from hexan-1-ol.

Chemoselective esterification and amidation of carboxylic acids with imidazole carbamates and ureas

Imidazole carbamates and ureas were found to be chemoselective esterification and amidation reagents. A wide variety of carboxylic acids were converted to their ester or amide analogues by a simple synthetic procedure in high yields.

Inhibition of peptidylglycine α-amidating monooxygenase by exploitation of factors affecting the stability and ease of formation of glycyl radicals

Peptidylglycine α-amidating monooxygenase catalyzes the biosynthesis of peptide hormones through radical cleavage of the C-terminal glycine residues of the corresponding prohormones. We have correlated ab initio calculations of radical stabilization energies and studies of free radical brominations with the extent of catalysis displayed by peptidylglycine α-amidating monooxygenase, to identify classes of inhibitors of the enzyme. In particular we find that, in closely related systems, the substitution of glycolate for glycine reduces the calculated radical stabilization energy by 34.7 kJ mol -1, decreases the rate of bromination with N-bromosuccinimide at reflux in carbon tetrachloride by a factor of at least 2000, and stops catalysis by the monooxygenase, while maintaining binding to the enzyme.

ENZYME INHIBITORS

A compound of Formula (I) wherein R is a biomolecular residue, or derivative thereof, of a C-terminal amide biomolecule which is activated by the action of PAM; and X is O or CH2 or a salt, or prodrug thereof.

IMIDAZO(1,2-a)PYRIDINE DERIVATIVE

A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.

Reactions of Trialkylsilyl Trifluoromethanesulfonates, VI. - Synthesis of 2-Heterosubstituted O-Alkyl-O-(trimethylsilyl)ketene Acetals and 2-(Trimethylsilyl)carboxylates

Organooxy- and (alkylthio)ethanoic acid esters 2 are silylated by trimethylsilyl triflate (1) in the presence of triethylamine to yield mixtures of ketene acetals 3 and 2-(trimethylsilyl)ethanoates 4.The product distributions 3/4 are governed by the ester groups and the substituents in α position.Cyclic derivatives of 2-hydroxycarboxylic acids 7,9 are silylated by 1/triethylamine to give the ketene acetals 8,10.From N-protected glycine methyl esters 11,12 the ketene acetals 13,15 are obtained in the reaction with 1/triethylamine.

SENSITIZED PHOTOOXIDATION OF 2,5-FURANYLDIMETHYL DIBENZOATE

Sensitized photooxidation of 2,5-furanyldimethyl dibenzoate was carried out in acetonitrile and methanol respectively.Two products 3 and 6 were obtained via O,O-diradical intermediate 15 which was discovered from ozonide for the first time.

Anodic Oxidation of O-Benzoylated α-Hydroxyacetic Acids - A Contribution to the Reactivity of Anodic Oxidated Carboxylate Ions - "Umpolung"

Anodic oxidation of O-benzoylated α-hydroxyacetic acid 1 at graphite electrodes in methanol leads to the corresponding mixed acylals 2 and methyl benzoates 3.The rate 2:3 depends on the substitution of the aromatic ring and can be correlated to Hammett's ?-values.