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High purity Various Specifications meso-2,3-Dimercaptosuccinic acid CAS:304-55-2
Cas No: 304-55-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Succimer
Cas No: 304-55-2
No Data No Data No Data CHANGCHUN WEIERSI IMPORT AND EXPORT TRADE CO.,LTD Contact Supplier
Purity 99.5% API Dimercaptosuccinic Acid/Dmsa 304-55-2
Cas No: 304-55-2
No Data 1 Kilogram 10 Metric Ton/Month Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
Hot selling Meso-2,3-DiMercaptosuccinic acid (DMSA)/ Succimer CAS 304-55-2 with high purity
Cas No: 304-55-2
USD $ 10.0-10.0 / Gram 500 Gram 2000 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Succimer
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No Data 1 Kilogram 1 Metric Ton/Month CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD Contact Supplier
Succimer Manufacturer/High quality/Best price/In stock
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Succimer - DMSA IN STOCK
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USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
99% up Succimer 304-55-2
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No Data 1 Kilogram 1000 Kilogram/Month Sinoway Industrial Co., Ltd. Contact Supplier
High quality Succimer supplier in China
Cas No: 304-55-2
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
Dimercaptosuccinic Acid / Dmsa Powder Price CAS 304-55-2
Cas No: 304-55-2
USD $ 100.0-100.0 / Kilogram 1 Kilogram 10 Metric Ton/Week Xi'an Quanao Biotech Co., Ltd. Contact Supplier

304-55-2 Usage

Chemical Properties

white or off-white powder

Veterinary Drugs and Treatments

In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended.

Purification Methods

Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]

Uses

chelating agent, treatment of lead poisoning

Uses

Chelating agent.

Uses

A water-soluble chelating agent.

Brand name

Chemet (Ovation).

Pharmaceutical Applications

Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent. DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.

Definition

ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.

Pharmaceutical Applications

The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.

Uses

meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.

Description

Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.

Uses

chelating agent, antihypertensive

Originator

Johnson and Johnson (J&J) (U.S.A.)

Uses

A selective masking agent for cadmium in EDTA titration of zinc.
InChI:InChI=1/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/p-2/t1-,2+

304-55-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (D1722)  meso-2,3-Dimercaptosuccinic Acid  >98.0%(T) 304-55-2 5g 990.00CNY Detail
TCI America (D1722)  meso-2,3-Dimercaptosuccinic Acid  >98.0%(T) 304-55-2 25g 2,750.00CNY Detail
Alfa Aesar (A17909)  meso-2,3-Dimercaptosuccinic acid, 97%    304-55-2 1g 216.0CNY Detail
Alfa Aesar (A17909)  meso-2,3-Dimercaptosuccinic acid, 97%    304-55-2 5g 778.0CNY Detail
Aldrich (D7881)  meso-2,3-Dimercaptosuccinicacid  ~98% 304-55-2 D7881-1G 313.56CNY Detail
Aldrich (D7881)  meso-2,3-Dimercaptosuccinicacid  ~98% 304-55-2 D7881-5G 1,003.86CNY Detail
Aldrich (D7881)  meso-2,3-Dimercaptosuccinicacid  ~98% 304-55-2 D7881-25G 3,707.73CNY Detail
Aldrich (D7881)  meso-2,3-Dimercaptosuccinicacid  ~98% 304-55-2 D7881-50G 5,694.39CNY Detail

304-55-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name succimer

1.2 Other means of identification

Product number -
Other names meso-dimercaptosuccinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:304-55-2 SDS

304-55-2Synthetic route

meso-2,3-bis(acetylthio)succinic acid
53318-26-6

meso-2,3-bis(acetylthio)succinic acid

succimer
304-55-2

succimer

Conditions
ConditionsYield
With sodium hydroxide
With water; hydrazine hydrate at 0℃;
succimer
304-55-2

succimer

trimethyltin(IV)chloride
1066-45-1

trimethyltin(IV)chloride

[(meso-2,3-dimercaptosuccinate)tetrakis(trimethyltin(IV))]

[(meso-2,3-dimercaptosuccinate)tetrakis(trimethyltin(IV))]

Conditions
ConditionsYield
With sodium ethoxide In methanol; toluene N2, acid:ethoxide:Sn=1:4:1 molar ratio, acid and base stirred for 0.5 h,Sn compd. added, stirred at 40°C for 12 h; filtered, solvent removed (vac.), recrystd. (ethanol); elem. anal.;88%
succimer
304-55-2

succimer

dimethyltin oxide
2273-45-2

dimethyltin oxide

[(meso-2,3-dimercaptosuccinate)bis(dimethyltin(IV))]

[(meso-2,3-dimercaptosuccinate)bis(dimethyltin(IV))]

Conditions
ConditionsYield
In methanol; toluene N2, stoich., refluxed in a Dean-Stark trap for 10 h; cooled to room temp., filtered, solvent removed (vac.); elem. anal.;88%
diethyl ether
60-29-7

diethyl ether

succimer
304-55-2

succimer

diphenyltin(IV) oxide
2273-51-0

diphenyltin(IV) oxide

[(meso-2,3-dimercaptosuccinate)bis(diphenylaquatin(IV))]-diethyl ether-water (1/1/1)

[(meso-2,3-dimercaptosuccinate)bis(diphenylaquatin(IV))]-diethyl ether-water (1/1/1)

Conditions
ConditionsYield
In methanol; toluene N2, stoich., refluxed in a Dean-Stark trap for 10 h; cooled to room temp., filtered, solvent removed (vac.), recrystd. (diethyl ether); elem. anal.;86%
methanol
67-56-1

methanol

succimer
304-55-2

succimer

tributyltin chloride
1461-22-9

tributyltin chloride

[di(meso-2,3-dimercaptosuccinate)tris(di-n-butyltin(IV))di(n-butyl)(methanol)tin(IV)]

[di(meso-2,3-dimercaptosuccinate)tris(di-n-butyltin(IV))di(n-butyl)(methanol)tin(IV)]

Conditions
ConditionsYield
With KOH In methanol; water High Pressure; N2, stoich., heated at 150°C for 3 d; cooled to room temp., crysts. filtered, washed (hexane); elem. anal., TGA;85%
With KOH In methanol; water High Pressure; mixt. of meso-2,3-dimercaptosuccinic acid (0.5 mmol), KOH (2 mmol), tri-n-butyltin chloride (2 mmol), CH3OH (10 ml) and H2O (5 ml) heated in Teflon-lined autoclave at 150°C for 3 d; cooled to room temp. for 24 h; crystals collected; washed with hexane; elem. anal.;85%
succimer
304-55-2

succimer

tributyltin chloride
1461-22-9

tributyltin chloride

[(meso-2,3-dimercaptosuccinate)tetrakis(tri-n-butyltin(IV))]

[(meso-2,3-dimercaptosuccinate)tetrakis(tri-n-butyltin(IV))]

Conditions
ConditionsYield
With sodium ethoxide In methanol; toluene N2, acid:ethoxide:Sn=1:4:1 molar ratio, acid and base stirred for 0.5 h,Sn compd. added, stirred at 40°C for 12 h; filtered, solvent removed (vac.); elem. anal.;85%
succimer
304-55-2

succimer

tribenzyltin(IV) chloride
3151-41-5

tribenzyltin(IV) chloride

[(meso-2,3-dimercaptosuccinate)tetrakis(tribenzyltin(IV))]

[(meso-2,3-dimercaptosuccinate)tetrakis(tribenzyltin(IV))]

Conditions
ConditionsYield
With sodium ethoxide In methanol; toluene N2, acid:ethoxide:Sn=1:4:1 molar ratio, acid and base stirred for 0.5 h,Sn compd. added, stirred at 40°C for 12 h; filtered, solvent removed (vac.); elem. anal.;85%
succimer
304-55-2

succimer

dibenzyltin oxide

dibenzyltin oxide

[(meso-2,3-dimercaptosuccinate)bis(dibenzyltin(IV))]
943909-25-9

[(meso-2,3-dimercaptosuccinate)bis(dibenzyltin(IV))]

Conditions
ConditionsYield
In methanol; toluene N2, stoich., refluxed in a Dean-Stark trap for 10 h; cooled to room temp., filtered, solvent removed (vac.); elem. anal.;83%
succimer
304-55-2

succimer

ammonium pertechnetate

ammonium pertechnetate

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

Na5[99TcO(meso-dimercaptosuccinic acid)2]

Na5[99TcO(meso-dimercaptosuccinic acid)2]

Conditions
ConditionsYield
With tin(II) chloride dihdyrate In water at 20℃; for 0.5h;83%
succimer
304-55-2

succimer

triphenyltin chloride
639-58-7

triphenyltin chloride

[(meso-2,3-dimercaptosuccinate)tetrakis(triphenyltin)]

[(meso-2,3-dimercaptosuccinate)tetrakis(triphenyltin)]

Conditions
ConditionsYield
With sodium ethoxide In methanol; toluene N2, acid:ethoxide:Sn=1:4:1 molar ratio, acid and base stirred for 0.5 h,Sn compd. added, stirred at 40°C for 12 h; filtered, solvent removed (vac.), recrystd. (CH2Cl2); elem. anal.;82%
succimer
304-55-2

succimer

di(n-butyl)tin oxide
818-08-6

di(n-butyl)tin oxide

[(meso-2,3-dimercaptosuccinate)bis(di-n-butyltin(IV))]

[(meso-2,3-dimercaptosuccinate)bis(di-n-butyltin(IV))]

Conditions
ConditionsYield
In methanol; toluene N2, stoich., refluxed in a Dean-Stark trap for 10 h; cooled to room temp., filtered, solvent removed (vac.); elem. anal.;80%
succimer
304-55-2

succimer

acetone
67-64-1

acetone

2,2-dimethyl-[1,3]dithiolane-4,5-dicarboxylic acid

2,2-dimethyl-[1,3]dithiolane-4,5-dicarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 9h;78%
With hydrogenchloride In water at 0 - 20℃;60%
methanol
67-56-1

methanol

succimer
304-55-2

succimer

meso-dimercaptosuccinic acid dimethylester
27887-85-0

meso-dimercaptosuccinic acid dimethylester

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 8h; Cooling with ice;77.6%
With sulfuric acid Heating;
ammonium perrhenate

ammonium perrhenate

succimer
304-55-2

succimer

ammonium syn-endo-oxobis(SCH(COOH)CH(COOH)S)rhenate(V)

ammonium syn-endo-oxobis(SCH(COOH)CH(COOH)S)rhenate(V)

Conditions
ConditionsYield
With acetylhydrazine; HCl In acetonitrile Re compd. and acetylhydrazine (molar ratio 1:1) stirred in MeCN at room temp. for 10 min; concd. HCl added; stirred for 25 min; dimercaptosuccinic acid (2 equiv.) added; stirred for 3 h; filtered; solid washed with MeCN; dried under vac.; elem. anal.;75%
succimer
304-55-2

succimer

nitarsone
98-72-6

nitarsone

2-(4-nitrophenyl)-1,3,2-dithiaarsolane-4,5-dicarboxylic acid

2-(4-nitrophenyl)-1,3,2-dithiaarsolane-4,5-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: nitarsone With ammonium 2-sulfanylacetate In ethanol; water; acetone at 55℃; for 1h;
Stage #2: succimer In acetone for 0.5h;
71%
ammonium perrhenate

ammonium perrhenate

succimer
304-55-2

succimer

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

Na5[ReO(meso-dimercaptosuccinic acid)2]

Na5[ReO(meso-dimercaptosuccinic acid)2]

Conditions
ConditionsYield
With tin(II) chloride dihdyrate In water at 20℃; for 0.5h;70%
{(C6H5)2AsCH2CH2P(C6H5)2PdCl2}*2CHCl3

{(C6H5)2AsCH2CH2P(C6H5)2PdCl2}*2CHCl3

succimer
304-55-2

succimer

{(C6H5)2AsCH2CH2P(C6H5)2Pd(SCH(COOH)CH(COOH)S)}*0.5C2H5OH

{(C6H5)2AsCH2CH2P(C6H5)2Pd(SCH(COOH)CH(COOH)S)}*0.5C2H5OH

Conditions
ConditionsYield
With NaOH In ethanol; water add. of aq. soln. of 0.38 mmol NaOH to soln. of 0.20 mmol acid in ethanol/water (5:1); after 10 min addn. of mixture to suspension of 0.17 mmol palladium complex in ethanol; after 2 h concg. soln.;; pptn.; elem. anal.;;69%
{(C6H5)2PCH2CH2P(C6H5)2PtCl2}*2CHCl3

{(C6H5)2PCH2CH2P(C6H5)2PtCl2}*2CHCl3

succimer
304-55-2

succimer

{(C6H5)2PCH2CH2P(C6H5)2Pt(SCH(COOH)CH(COOH)S)}

{(C6H5)2PCH2CH2P(C6H5)2Pt(SCH(COOH)CH(COOH)S)}

Conditions
ConditionsYield
With NaOH In ethanol; water add. of aq. soln. of 0.32 mmol NaOH to soln. of 0.35 mmol acid in ethanol/water (3:1); after 10 min addn. of mixture to suspension of 0.29 mmol platinum phosphine chloride in ethanol; after 1.5 h filtration; concg. filtrate;; pptn.; elem. anal.;;68%
p-aminophenylarsonic acid
98-50-0

p-aminophenylarsonic acid

succimer
304-55-2

succimer

2-(4-aminophenyl)-1,3,2-dithiaarsolane-4,5-dicarboxylic acid

2-(4-aminophenyl)-1,3,2-dithiaarsolane-4,5-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: p-aminophenylarsonic acid With ammonium 2-sulfanylacetate In ethanol at 55℃; for 1h;
Stage #2: succimer In ethanol for 0.5h;
68%
{(C6H5)2PCH2CH2P(C6H5)2PdCl2}*2CHCl3

{(C6H5)2PCH2CH2P(C6H5)2PdCl2}*2CHCl3

succimer
304-55-2

succimer

{(C6H5)2PCH2CH2P(C6H5)2Pd(SCH(COOH)CH(COOH)S)}*C2H5OH

{(C6H5)2PCH2CH2P(C6H5)2Pd(SCH(COOH)CH(COOH)S)}*C2H5OH

Conditions
ConditionsYield
With NaOH In ethanol; water add. of aq. soln. of 0.5 mmol NaOH to soln. of 0.478 mmol acid in ethanol/water (5:1); after 10 min addn. of mixture to suspension of 0.29 mmol palladium phosphine chloride in ethanol; after 2 h concg. soln.;; pptn.; elem. anal.;;64%
{(C6H5)2AsCH2CH2P(C6H5)2PtCl2}*2CHCl3

{(C6H5)2AsCH2CH2P(C6H5)2PtCl2}*2CHCl3

succimer
304-55-2

succimer

{(C6H5)2AsCH2CH2P(C6H5)2Pt(SCH(COOH)CH(COOH)S)}*C2H5OH

{(C6H5)2AsCH2CH2P(C6H5)2Pt(SCH(COOH)CH(COOH)S)}*C2H5OH

Conditions
ConditionsYield
With NaOH In ethanol; water add. of aq. soln. of 0.16 mmol NaOH to soln. of 0.16 mmol acid in ethanol/water (3:1); after 10 min addn. of mixture to suspension of 0.15 mmol platinum complex in ethanol; after 2 h filtration; concg. filtrate;; pptn.; elem. anal.;;62.5%
cis-[NiBr2(1,2-bis(diphenylphosphino)ethane)]
14647-21-3

cis-[NiBr2(1,2-bis(diphenylphosphino)ethane)]

succimer
304-55-2

succimer

{(C6H5)2PCH2CH2P(C6H5)2Ni(SCH(COOH)CH(COOH)S)}*2H2O

{(C6H5)2PCH2CH2P(C6H5)2Ni(SCH(COOH)CH(COOH)S)}*2H2O

Conditions
ConditionsYield
In ethanol addn. of Ni complex to acid in ethanol; stirring for 2 h; filtration;; dissolving residue in aq. NaOH (pH = 10); addn. of dilute H2SO4; pptn.; elem. anal.;;54.2%
succimer
304-55-2

succimer

4-ethoxyphenylarsonic acid
6269-93-8

4-ethoxyphenylarsonic acid

2-(4-ethoxyphenyl)-1,3,2-dithiaarsolane-4,5-dicarboxylic acid

2-(4-ethoxyphenyl)-1,3,2-dithiaarsolane-4,5-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: 4-ethoxyphenylarsonic acid With ammonium 2-sulfanylacetate In ethanol at 55℃; for 1h;
Stage #2: succimer In ethanol for 0.5h;
32.8%
(E)-1-(4-(phenyldiazenyl)phenyl)-1H-pyrrole-2,5-dione
136733-06-7

(E)-1-(4-(phenyldiazenyl)phenyl)-1H-pyrrole-2,5-dione

succimer
304-55-2

succimer

2,3-bis[(2,5-dioxo-1-{4-[(E)-2-phenyldiazen-1-yl]phenyl}pyrrolidin-3-yl)sulfanyl] butanedioic acid

2,3-bis[(2,5-dioxo-1-{4-[(E)-2-phenyldiazen-1-yl]phenyl}pyrrolidin-3-yl)sulfanyl] butanedioic acid

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 4h;24.8%
formaldehyd
50-00-0

formaldehyd

succimer
304-55-2

succimer

(4S,5R)-[1,3]Dithiolane-4,5-dicarboxylic acid
28152-58-1

(4S,5R)-[1,3]Dithiolane-4,5-dicarboxylic acid

Conditions
ConditionsYield
With hydrogen cation
methanol
67-56-1

methanol

succimer
304-55-2

succimer

propargyl bromide
106-96-7

propargyl bromide

(2R,3S)-2,3-Bis-prop-2-ynylsulfanyl-succinic acid dimethyl ester

(2R,3S)-2,3-Bis-prop-2-ynylsulfanyl-succinic acid dimethyl ester

Conditions
ConditionsYield
With potassium hydroxide Alkylation; Heating;
i-Amyl alcohol
123-51-3

i-Amyl alcohol

succimer
304-55-2

succimer

monoisoamyl meso 2,3-dimercaptosuccinic acid

monoisoamyl meso 2,3-dimercaptosuccinic acid

succimer
304-55-2

succimer

cadmium(II) nitrate

cadmium(II) nitrate

2Cd(2+)*(SCHCOO)2(4-)*2H2O = (SCHCO2)2Cd2*2H2O

2Cd(2+)*(SCHCOO)2(4-)*2H2O = (SCHCO2)2Cd2*2H2O

Conditions
ConditionsYield
With sodium hydroxide In not given soln. with ratio Cd(NO3)2:org. compd.:NaOH 3:1:4; filtration, washing (aq. EtOH), drying (room temp.); elem. anal.;
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