white or off-white powder
Veterinary Drugs and Treatments
In veterinary medicine, succimer may be useful for the oral
treatment of lead poisoning in small animals (including birds).
Potentially, it also may be of benefit for the treatment of other toxic
heavy metals such as arsenic or mercury, but more research must be
done before this can be recommended.
Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]
chelating agent, treatment of lead poisoning
A water-soluble chelating agent.
Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant
smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name
is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are
two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment
of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been
successfully used for the treatment of heavy-metal poisoning.
ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment
of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating
agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are
also used in alternative medicine, which has led to much criticism and discussion. So far, no medical
study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal
meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.
Succimer is a newly available oral chelator of lead and other heavy metals. The
compound is indicated for the treatment of lead poisoning in children. Succimer does
not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic
over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may
also be effective in adults.
chelating agent, antihypertensive
Johnson and Johnson (J&J) (U.S.A.)
A selective masking agent for cadmium in EDTA titration of zinc.