312-33-4

Upstream product

• 56-23-5 tetrachloromethane 
• 462-06-6 fluorobenzene 
• 345-92-6 4,4'-Difluorobenzophenone 
• 7446-70-0 aluminium trichloride 
• 108-90-7 chlorobenzene 
• 402-44-8 4-Fluorobenzotrifluoride 

Downstream Products

• 10345-72-9 4,4'-difluorobenzophenone dimethyl acetal 
• 656805-49-1 5-bromo-6-fluoro-2,2-bis(4-fluorophenyl)benzo[1,3]dioxole 
• 656804-79-4 [6-fluoro-2,2-bis-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone 
• 457-68-1 4,4'-difluorodiphenylmethane 
• 424-81-7 1,2-dichloro-1,1,2,2-tetrakis-(4-fluoro-phenyl)-ethane 
• 19422-37-8 1,1,2,2-tetrakis(4-fluorophenyl)ethane 
• 339-27-5 difluorophenyl-di-(p-fluorophenyl)methane 
• 345-92-6 4,4'-Difluorobenzophenone 
• 435-08-5 1,1,2,2-tetrakis(4-fluoroophenyl)ethylene 

Relevant academic research and scientific papers

Influence of isomerism of difluorobenzophenone on the synthesis and properties of poly(arylene ether ketones)

The influence of isomerism of difluorobenzophenone on the efficiency of polycondensation and the properties of homo-and copoly(arylene ether ketones) was studied. The latter were prepared by the reaction of 2,4'-and 4,4'-difluorobenzophenone with potassium diphenolates of bisphenol A and phenolphthalein in N,N-dimethylacetamide. A high content of an admixture of the 2,4'-isomer in 4,4'-difluorobenzophenone decreases the molecular weight of related poly(arylene ether ketones) and has no substantial effect on their glass transition temperature.

Novel Friedel-Crafts reaction method and catalyst thereof

The present invention relates to a novel method for preparing or synthesizing an acylated or alkylated aryl compound, such as acylated or alkylated benzene, through a reaction called Friedel-Crafts, and a novel catalyst for the method. The present invention particularly relates to a novel environment-friendly method for synthesizing the Friedel-Crafts reaction of the acylated or alkylated compound.

Novel process for producing phenyl fluoride, diphenyl ketone fluoride, and derivatives thereof

The invention relates to a novel process for producing phenyl fluoride, diphenyl ketone fluoride, and derivatives thereof, especially the phenyl fluoride and derivatives thereof. The invention especially relates to a novel environment-friendly process for synthesizing phenyl fluoride and diphenyl ketone fluoride, which are the raw materials for preparing polyaryl-ether-ketone PAEK. The invention discloses the method that is more effective and environment-friendly for preparing the compounds through a Friedel-Crafts reaction, and further a more environment-friendly process, and provdies beneficial catalysts. Another object of the present invention is to employ the Friedel-Crafts reaction and adopts the beneficial catalysts, wherein the catalyst can be easily combined with the fluoridation reaction which can be carried out before, or after the Friedel-Crafts reaction. Herein, another object of the invention is to use the catalyst in the Friedel-Crafts reaction, wherein the catalyst can work in both the Friedel-Crafts reaction and the fluoridation reaction.

Preparation method of 4,4'-difluorobenzophenone

The invention relates to a preparation method of 4,4'-difluorobenzophenone, belonging to the field of chemical synthesis. The preparation method comprises the steps of carrying out acylation reaction on fluorine benzotrichloride and fluorobenzene under the catalysis of aluminum trichloride, and carrying out hydrolysis reaction, so as to obtain 4,4'-difluorobenzophenone. The preparation method of 4,4'-difluorobenzophenone has the beneficial effects of simple process, high yield, good selectivity and low cost.

Benzodioxoles: Novel cannabinoid-1 receptor inverse agonists for the treatment of obesity

The application of the evolutionary fragment-based de novo design tool TOPology Assigning System (TOPAS), starting from a known CB1R (CB-1 receptor) ligand, followed by further refinement principles, including pharmacophore compliance, chemical tractabili

NOVEL BENZODIOXOLES

The present invention relates to compound of formula (I) Wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.

Bis-imidazolyl-bisphenylmethane and salts thereof

Bis-imidazolyl-bisphenylmethane derivatives and pharmaceutically acceptable non-toxic salts thereof are useful as antimycotics especially against dermatomycosis caused by Trichophyton and Microsporium species and also against yeast infections of the skin and internal organs.