4834-61-1

Basic information

• Product Name: 4-Benzoyl Acetanilide
• Synonyms: 4-(ACETYLAMINO)BENZOPHENONE;4-(ACETYLAMINO)BENZO9PHENONE;N-[4-(phenylcarbonyl)phenyl]acetamide
• CAS NO: 4834-61-1
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.26922
• Mol File: 4834-61-1.mol
• Article Data: 26

Chemical Properties

• Melting Point: 150-151 °C
• Boiling Point: 459.8 °C at 760 mmHg
• Flash Point: 187.7 °C
• Appearance: /
• Density: 1.192 g/cm³
• Vapor Pressure: 1.23E-08mmHg at 25°C
• Refractive Index: 1.618
• PKA: 14.57±0.70(Predicted)
• CAS DataBase Reference: 4-Benzoyl Acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzoyl Acetanilide(4834-61-1)
• EPA Substance Registry System: 4-Benzoyl Acetanilide(4834-61-1)

Safety Data

• Hazardous Substances Data: 4834-61-1(Hazardous Substances Data)

Usage

General Description

4-Benzoyl Acetanilide is a chemical compound with the formula C15H13NO2. This organic substance is most commonly known for its use in several laboratory reactions. The chemical can be considered as a derivative of aniline that undergoes multiple acylation processes. The benzoyl group (C6H5CO-) present in 4-Benzoyl Acetanilide contributes to the compound's overall reactivity. However, usage demands cautious handling as it may pose health hazards when not administered properly. Though it does not have widespread uses in everyday life, it has significant relevance in various chemical and pharmaceutical research. The compound is often used as an intermediary in producing other chemicals.

InChI:InChI=1/C15H13NO2/c1-11(17)16-14-9-7-13(8-10-14)15(18)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17)

Upstream product

• 98-07-7 Benzotrichlorid 
• 103-84-4 Acetanilid 
• 98-88-4 benzoyl chloride 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 589-87-7 1,4-bromoiodobenzene 
• 60-35-5 acetamide 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 100-52-7 benzaldehyde 
• 556-08-1 p-(acetylamino)benzoic acid 
• 71-43-2 benzene 
• 587-48-4 3-acetylaminobenzoic acid 
• 611-73-4 Benzoylformic acid 
• 1144-74-7 4-nitrobenzophenone 

Downstream Products

• 29551-83-5 acetic acid-(4-benzoyl-N-chloro-anilide) 
• 860746-21-0 acetic acid-(4-benzoyl-2-bromo-anilide) 
• 127269-19-6 4-phenylazo-benzophenone 
• 66067-44-5 (3-acetylphenyl)(phenyl)methanone 
• 22071-15-4 ketoprofen 
• 1416085-74-9 N-(4-benzoyl-2-(trifluoromethyl)phenyl)acetamide 
• 179552-09-1 N-(2-diethylaminoethyl)-N-acetyl-4-aminobenzophenone 

Relevant articles and documents

Enhanced catalytic activity of one-dimensional CdS @TiO2 core-shell nanocomposites for selective organic transformations under visible LED irradiation

In this study, we are interested in the photocatalytic activity under visible LED irradiation of one- dimensional (1D) CdS @TiO2 core–shell nanocomposites (CSNs) prepared through a facile and convenient method. For the synthesis of 1D CdS@TiO2 core/shell structure, titania source (Tetrabutyl titanate) was hydrolyzed by water vapor transmission on the surface of CdS nanowires (NWs) which were prepared via solvothermal method. The characterization of 1D CdS@TiO2 core–shell nanocomposites (CdS@TiO2 CSNs) was performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy, and UV–Vis diffuse reflectance spectroscopy (DRS). The as-synthesized sample was utilized for the selective reduction of nitro compounds to benzimidazole and anilide, and also the reduction of benzophenones to alcohol under blue LED irradiation. The 1D CdS@TiO2 CSNs exhibited enhanced photoactivity compared with the pure TiO2, CdS nanowires and commercial TiO2-P25. The excellent reusability of the photocatalyst was examined for six runs. The results demonstrated that the prepared sample has the potential to provide a promising visible light-driven photocatalyst for other organic transformations.

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving “diversity with ease”, by combining classic C?C π-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels–Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates—demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.

Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones

Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.