32846-66-5Relevant articles and documents
Molecular Reorientation and Self-Diffusion in Solid Cubane by Deuterium and Proton NMR
Detken, A.,Zimmermann, H.,Haeberlen, U.,Poupko, R.,Luz, Z.
, p. 9598 - 9604 (1996)
Deuterium and proton NMR line shape and relaxation measurements are reported for the sym-cubane-d2 isotopomer (D3d symmetry) in the temperature range from 200 K to the melting point of the solid.The results confirm the polymorphic phase sequence: solid II solid I liquid, reported earlier by White et al.The deuterium spectrum below 215 K exhibits a Pake doublet corresponding to an axially symmetric quadrupole coupling tensor with a coupling comstant of Qc = 178 kHz.Above this temperature the spectrum develops features characteristic of the onset of dynamic processes leading to a single line at about room temperature.Longitudinal relaxation time measurements show a T1 minimum at 344 K.On transition to solid I there is a discontinuous narrowing of the line and a concomitant increase in T1.These results are quantitatively interpreted in terms of reorientational jumps of the cubane molecules between their various equivalent orientations.The jump rate k in solid II follows an Arrhenius behavior over the range of almost seven decades with an activation energy E = 62 kJ mol-1.Transition to solid I results in a discontinuous increase of k.Proton line width measurements in solid II show two motional narrowing steps.The first, at around 240 K, is due to the cubic jumps while the second, at around 375 K, corresponds to molecular self-diffusion between the lattice sites.The activation energy for this process is Ed = 83 kJ mol-1.On transition to solid I there is also a discontinuous increase in the rate of this process.The proton T1 values are predominantly affected by the reorientation process and are consistent with the deuteron data.At temperatures above 340 K, where the deuterium NMR spectrum is expected to be a single Lorentzian with a width of less than 400 Hz, it actually exhibits, in both phases II and I, a Pake doublet corresponding to an axially symmetric quadrupole coupling tensor with a very small coupling constant Q'c = 0.48 kHz.This indicates that the reaorientation process is not perfectly cubic.Possible reasons for this surprising effect are discussed.
Enantioselective synthesis of (: R)-2-cubylglycine including unprecedented rhodium mediated C-H insertion of cubane
Houston, Sevan D.,Chalmers, Benjamin A.,Savage, G. Paul,Williams, Craig M.
supporting information, p. 1067 - 1070 (2019/02/07)
The first enantioselective synthesis of (R)-2-cubylglycine, an analogue of (R)-2-phenylglycine in which the phenyl ring has been replaced by cubane, is disclosed. The key step was a telescoped Strecker reaction using (S)-2-amino-2-phenylethanol as a chiral auxiliary. Exploration of an alternative synthetic approach resulted in unprecedented cubane C-H insertion.
Cubane Arrives on the Cucurbituril Scene
Jelínková, Kristyna,Surmová, Heda,Matelová, Alena,Rouchal, Michal,Prucková, Zdeňka,Dastychová, Lenka,Ne?as, Marek,Vícha, Robert
, p. 2698 - 2701 (2017/05/24)
Cubane, an intriguing chemical curiosity first studied in the early 1960s, has become a valuable structural motif and has recently been involved in the structures of a great number of prospective compounds. The first dicationic supramolecular guest 5 is prepared and derived from a 1,4-disubstituted cubane moiety, and its binding behavior toward cucurbit[n]urils (CBn) and cyclodextrins (CD) is studied. The bisimidazolium salt 5 forms 1:1 inclusion complexes with CB7, CB8, and β-CD with the respective association constants (6.7 ± 0.5) × 1011 M-1, (1.5 ± 0.2) × 109 M-1, and 2 M-1 in water. The solid-state structures of the 5@CB7 and 5@CB8 complexes are also reported.
