33224-99-6Relevant articles and documents
SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND
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Paragraph 0925-0927, (2017/09/12)
Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein L1 is an optionally substituted C1-6 alkylene group or the like, L2 is a single bond or the like, L3 is a single bond or the like, R1, R2, and R3 are each independently an optionally substituted C1-4 alkyl group or the like, R4 is a hydrogen atom or the like, and R5 is a hydrogen atom or the like.
1, 3, 4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER
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Page/Page column 87; 88, (2016/02/26)
The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R1 and R2 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent GLS1 mediated disease, including cancer. The specification further relates to crystalline forms of compounds of Formula (I) and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating GLS1 kinase mediated disease, including cancer, using such compounds and salts.
Photolysis of Alkoxyacetic Acids in the presence of Mercury(II) Oxide and Iodine
Glover, Stephen A.,Golding, Stephen L.,Goosen, Andre,McCleland, Cedric W.
, p. 2479 - 2483 (2007/10/02)
Homolytic decarboxylation of a series of alkoxyacetic acids has furnished alkoxyalkyl alkoxyacetates when no substituents were present at the 2-position.Electron donating and withdrawing 2-substituents, with the exception of trichloromethyl, afforded products due to fragmentation of the alkoxyacetic acids.The reaction pathway is rationalised on the basis of the reactivity of the alkoxyalkyl iodide intermediates.
