3346-44-9

Basic information

• Product Name: 2,5-Diphenyl-3,4-dihydro-2H-1,2,4-triazole-3-one
• Synonyms: 1,3-Diphenyl-1H-1,2,4-triazol-5(4H)-one;2,5-Diphenyl-3,4-dihydro-2H-1,2,4-triazole-3-one;2,5-diphenyl-1H-1,2,4-triazol-3-one
• CAS NO: 3346-44-9
• Molecular Formula: C₁₄H₁₁N₃O
• Molecular Weight: 0
• Mol File: 3346-44-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-Diphenyl-3,4-dihydro-2H-1,2,4-triazole-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Diphenyl-3,4-dihydro-2H-1,2,4-triazole-3-one(3346-44-9)
• EPA Substance Registry System: 2,5-Diphenyl-3,4-dihydro-2H-1,2,4-triazole-3-one(3346-44-9)

Safety Data

• Hazardous Substances Data: 3346-44-9(Hazardous Substances Data)

Upstream product

• 5877-07-6 benzaldehyde-(2-phenyl semicarbazone) 
• 100-63-0 phenylhydrazine 
• 98-88-4 benzoyl chloride 
• 917-61-3 sodium isocyanate 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 590-28-3 potassium cyanate 
• 124-38-9 carbon dioxide 
• 46721-85-1 N′-phenylbenzimidohydrazide 
• 728-95-0 phenyl-phenylhydrazono-acetic acid 
• 107835-22-3 1-Methyl-3-(phenylbenzhydrazonoyl)uracil 
• 4461-33-0 benzoyl isocyanate 
• 103-02-6 acetone phenylhydrazone 
• 825-60-5 benzimidic acid ethyl ester 
• 101934-62-7 Ethyl N-(methoxycarbonyl)-benzenecarboximidate 

Downstream Products

• 931426-80-1 2-(5-oxo-1,3-diphenyl-1,5-dihydro-4H-1,2,4-triazol-4-yl)acetamide 
• 32589-67-6 4-acetyl-2,5-diphenyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 27423-52-5 ethyl (5-oxo-1,3-diphenyl-1,5-dihydro-4H-1,2,4-triazol-4-yl)acetate 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Palladium-Catalyzed cascade carbonylative synthesis of 1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3

A palladium-catalyzed three-component carbonylative reaction for the synthesis of 3H-1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3 has been achieved. The reaction presumably proceeds through a cascade carbonylation, acyl azide format

The Base-Promoted Annulation of 2-Hydrazinyl Pyridine and CO2 toward Triazolones

A base-promoted annulation of 2-hydrazinyl pyridine and atmospheric pressure of CO2 has been developed in the presence of silane as reducing reagent, affording a series of triazolones in moderate to excellent yields. CO2 served as a carbonyl source in this transfomation. Moreover, benzamidrazones also worked well under this procedure. Thus, it represents a green, sustainable and straightforward pathway to access triazolone frameworks. (Figure presented.).