3346-44-9

Upstream product

• 52328-57-1 ethyl phenylhydrazono(phenyl)acetate 
• 5877-07-6 benzaldehyde-(2-phenyl semicarbazone) 
• 728-95-0 phenyl-phenylhydrazono-acetic acid 
• 39536-03-3 N-(phenylcarbamothioyl)benzenecarboximidamide 
• 100-63-0 phenylhydrazine 
• 98-88-4 benzoyl chloride 
• 917-61-3 sodium isocyanate 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 590-28-3 potassium cyanate 
• 108-73-6 3,5-dihydroxyphenol 
• 532-96-7 N-benzoyl-N'-phenylhydrazine 
• 124-38-9 carbon dioxide 
• 46721-85-1 N′-phenylbenzimidohydrazide 
• 51384-17-9 5-(methylsulfanyl)-1,3-diphenyl-1,2,4-triazole 

Downstream Products

• 27423-52-5 ethyl (5-oxo-1,3-diphenyl-1,5-dihydro-4H-1,2,4-triazol-4-yl)acetate 
• 32589-67-6 4-acetyl-2,5-diphenyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 931426-80-1 2-(5-oxo-1,3-diphenyl-1,5-dihydro-4H-1,2,4-triazol-4-yl)acetamide 

Relevant academic research and scientific papers

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Green preparation method of 1,2,4-triazol-3-one compound

The invention discloses a green preparation method of a 1,2,4-triazol-3-one compound. The green preparation method comprises the following steps: adding a nickel accelerant, triethylamine, chlorohydrazone and sodium cyanate into an organic solvent, conduc

Palladium-Catalyzed cascade carbonylative synthesis of 1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3

A palladium-catalyzed three-component carbonylative reaction for the synthesis of 3H-1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3 has been achieved. The reaction presumably proceeds through a cascade carbonylation, acyl azide format

Preparation method of 1,2,4-triazol-3-one compound

The invention discloses a preparation method of a 1,2,4-triazol-3-one compound. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, chlorohydrazone and sodium azide into an organic sol

The Base-Promoted Annulation of 2-Hydrazinyl Pyridine and CO2 toward Triazolones

A base-promoted annulation of 2-hydrazinyl pyridine and atmospheric pressure of CO2 has been developed in the presence of silane as reducing reagent, affording a series of triazolones in moderate to excellent yields. CO2 served as a carbonyl source in this transfomation. Moreover, benzamidrazones also worked well under this procedure. Thus, it represents a green, sustainable and straightforward pathway to access triazolone frameworks. (Figure presented.).

Copper-Mediated Intramolecular N-N Bond Coupling Using Cerium(IV) Sulfate as the Oxidant for the Synthesis of 5-Thio-Substituted 1,2,4-Triazoles

A method for copper(II)-mediated N-N bond formation of N-imidoylisothioureas has been developed for the synthesis of 1,2,4-triazoles. The reaction requires cerium(IV) sulfate as an oxidant and proceeds at room temperature. This approach provides access to a variety of substituted 1,2,4-triazoles.

REACTION OF 1-METHYLURACIL WITH PHENYLBENZHYDRAZONOYL CHLORIDE

The ambident anion of 1-methyluracil gives with phenylbenzhydrazonoyl chloride, depending on the conditions, the N-acylation product (polar solvent, room temperature), or the O-acylation product (nonpolar solvent, heating), which rearranges to a cytosine derivative.Convenient methods have been developed for the preparation of 6-methyl-1,3-diphenyl-5,6-dihydro-5-oxopyrimidotriazolium chloride, a fluorescent derivative of 1-methyluracil, from the N-acylation product, and for the rapid base cleavage of the uracil ring under very mild conditions.

Reactions of Sulfur Monochloride with some Aromatic Aldehyde Semicarbazones and Thiosemicarbazones: New Syntheses of Substituted 2,4-Dihydro-1,2,4-triazol-3-ones, 2,4-Dihydro-1,2,4-triazole-3-thiones and 2-Amino-1,3,4-oxadiazoles

Treatment of various substituted semicarbazones of aromatic aldehydes with sulfur monochloride yields the corresponding substituted 2,4-dihydro-1,2,4-triazol-3-ones.With thiosemicarbazones, the products are derivatives either of the 2-amino-1,3,4-thiadiaz

A CONVENIENT SYNTHESIS OF 1-ARYL-Δ2-1,2,4-TRIAZOLIN-5-ONES FROM ARYLHYDRAZINES

1-Aryl-1,2,4-triazolin-5-ones are prepared from arylhydrazones of α-keto acids by treatment with diphenylphosphoryl azide.