3366-72-1

Basic information

• Product Name: P-TOLYL-PHOSPHONIC ACID
• Synonyms: P-TOLYL-PHOSPHONIC ACID;4-Methylphenylphosphonic acid
• CAS NO: 3366-72-1
• Molecular Formula: C₇H₉O₃P
• Molecular Weight: 172.118321
• Mol File: 3366-72-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 185 °C
• Boiling Point: 355.8°Cat760mmHg
• Flash Point: 169°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• PKA: pK1:1.84;pK2:7.33 (25°C)
• CAS DataBase Reference: P-TOLYL-PHOSPHONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYL-PHOSPHONIC ACID(3366-72-1)
• EPA Substance Registry System: P-TOLYL-PHOSPHONIC ACID(3366-72-1)

Safety Data

• Hazardous Substances Data: 3366-72-1(Hazardous Substances Data)

Usage

General Description

P-Tolyl-phosphonic acid, also known as p-tolylphosphonic acid or p-Methylbenzyl phosphonic acid, is a chemical compound commonly used in scientific research and in various manufacturing processes. Its molecular formula is C8H9O3P. P-TOLYL-PHOSPHONIC ACID belongs to the class of organic compounds known as benzenoids which are characterized by benzene rings. It is a relatively stable chemical; however, like many phosphonic acids, it should be handled with care as it can pose risks if it comes into contact with the skin or eyes, or if ingested or inhaled. It is commonly stored in a cool, dry place in tightly closed containers. It is primarily utilized in the field of chemistry as a reagent. Its detailed properties are reliant on precise measurement and vary according to several factors, including temperature and pressure.

InChI:InChI=1/C7H9O3P/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)

Upstream product

• 51303-75-4 tetrachloro-p-tolylphosphorane 
• 7732-18-5 water 
• 624-31-7 4-tolyl iodide 
• 108-88-3 toluene 
• 537-64-4 bis(p-tolyl)mercury 
• 1005-32-9 p-tolyldichlorophosphine 
• 106-38-7 para-bromotoluene 
• 6840-25-1 dimethyl (4-methylphenyl)phosphonate 
• 104412-66-0 bis(trimethylsilyl)-p-tolylphosphonate 
• 1754-46-7 diethyl 4-methylphenylphosphonate 
• 814-49-3 diethyl chlorophosphate 
• 2417-95-0 p-tolyllithium 
• 106-49-0 p-toluidine 
• 17566-84-6 p-tolylphosphonic dichloride 

Downstream Products

• 106-38-7 para-bromotoluene 
• 86119-84-8 phosphoric acid 
• 108-88-3 toluene 
• 98334-25-9 (4-aminomethyl-phenyl)-phosphonic acid 
• 131066-53-0 methyl (p-methylphenyl)phosphonic acid 
• 128333-46-0 p-Tolyl-phosphonic acid monohexyl ester 

Relevant articles and documents

Hydrolysis and alcoholysis of phosphinates and phosphonates

Phosphinic and phosphonic acids useful intermediates and biologically active compounds may be prepared from their esters: phosphinates and phosphonates, respectively, by acid-catalyzed hydrolysis either on conventional heating or on MW irradiation. The transesterification of alkyl phosphinates took place only in the presence of suitable ionic liquids as the catalysts. In the cases of phenylphosphonates, depending on the nature of the ionic liquid, the formation of the ester was accompanied by the fission of the C–O bond.

Synthesis and proton dissociation properties of arylphosphonates: A microwave-assisted catalytic arbuzov reaction with aryl bromides

A series of substituted diethyl arylphosphonates was synthesized by the microwave-assisted Arbuzov reaction of triethyl phosphite and aryl bromides in the presence of NiCl2 as the catalyst under solvent-free conditions in good yields. The resulting phosphonates were hydrolyzed to the corresponding arylphosphonic acids whose acidity was evaluated by physicochemical methods.

SYNTHESIS OF ARYL- AND HETARYLPHOSPHONATES

The reaction of tris(trimethylsilyl) phosphite with aryl or hetaryl halides under homogeneous catalysis conditions gave bis(trimethylsilyl)phosphonates.Treatment of these products with methanol gave the corresponding aryl- or hetarylphosphonic acids in quantitative yield.Keywords: tris(trimethylsilyl) phosphite, aryl and hetaryl halides, homogeneous catalysis, bis(trimethylsilyl)phosphonates, arylphosphonic acids.