6840-25-1

Upstream product

• 624-31-7 4-tolyl iodide 
• 121-45-9 phosphorous acid trimethyl ester 
• 60565-88-0 bis(4-methylphenyl)iodonium hexafluorophosphate 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 106-38-7 para-bromotoluene 
• 868-85-9 Dimethyl phosphite 
• 106-43-4 para-chlorotoluene 
• 539-44-6 N-4-methylphenylhydrazine 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 5720-05-8 4-methylphenylboronic acid 
• 692777-32-5 3,4-dibromo-3-methyl-1-p-tolyl-phospholane 1-oxide 

Downstream Products

• 3366-72-1 (4-methylphenyl)phosphonic acid 

Relevant academic research and scientific papers

Reaction of haloarenetricarbonylchromium with trimethylphosphite: palladium-catalyzed Arbuzov reaction versus arene displacement by trimethylphosphite

The Arbuzov reaction of trimethylphosphite with p-bromo-, and also with p-chloro-toluenetricarbonylchromium is achieved at 80-120 deg C, in the presence of a Pd0 or PdII complex, which acts as a catalyst.A competitive displacement of

C-P bond formation of cyclophanyl-, and aryl halides: Via a UV-induced photo Arbuzov reaction: A versatile portal to phosphonate-grafted scaffolds

A new versatile method for the C-P bond formation of (hetero)aryl halides with trimethyl phosphite via a UV-induced photo-Arbuzov reaction, accessing diverse phosphonate-grafted arenes, heteroarenes and co-facially stacked cyclophanes under mild reaction

Photoinduced Transition-Metal-Free Cross-Coupling of Aryl Halides with H-Phosphonates

Photoinduced transition-metal- and photosensitizer-free cross-coupling of aryl halides (including Ar-Cl, Ar-Br, and Ar-I) with H-phosphonates (including dialkyl phosphonates and diarylphosphine oxides) is reported. Various functional groups were tolerated, including ester, methoxy, dimethoxy, alkyl, phenyl, trifluoromethyl, and heterocyclic compounds. This simple and green strategy provides a practical pathway to synthesize arylphosphine oxides.

A mild electroassisted synthesis of (hetero)arylphosphonates

The electrochemically-assisted synthesis of (hetero)arylphosphonates from (hetero)aryl halides and dimethyl phosphite is described. Very mild and simple conditions are employed as the cross-coupling is carried out in galvanostatic mode, in an undivided ce

Copper-catalyzed coupling reaction of arylhydrazines and trialkylphosphites

A novel CuO-catalyzed coupling reaction of arylhydrazines with trialkyl phosphites to afford arylphosphonates is described. The reaction proceeded at 80 C in air without external reductants, oxidants, and ligands.

Palladium-catalyzed desulfitative C-P coupling of arylsulfinate metal salts and H-phosphonates

Catalyzed by palladium(ii) chloride, a diverse range of arylsulfinate sodium, potassium, lithium, silver, zinc, and copper salts undergo desulfination/C-P coupling with H-phosphonates, in the presence of silver(i) carbonate as oxidant, to produce useful arylphosphonates under microwave irradiation. the Partner Organisations 2014.

Palladium-catalyzed desulfitative cross-coupling reaction of sodium arylsulfinates with H-phosphonate diesters

A novel and convenient palladium-catalyzed cross-coupling reaction of H-phosphonate diesters with sodium arylsulfinates was developed via desulfitation in the presence of silver carbonate and tetra-butylammonium chloride. This method is highly efficient and provides a rapid access to a broad spectrum of arylphosphonate diesters in good to excellent yields.

Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates

The first PdII-catalyzed P arylation has been performed by using palladium acetate, the rigid bidentate ligand dmphen (dmphen=2,9-dimethyl-1,10- phenanthroline), and without the addition of base or acid. Couplings of arylboronic acids or aryl t

Aryl-2,3-oxaphosphabicyclo[2.2.2]octene derivatives - The precursors of oxoarylphosphine oxides (aryl metaphosphonates)

The Baeyer-Villiger oxidation of 7-phosphanorbornene 7-oxides with sterically demanding substituents on the phosphorus atom (4a-d) by m-chloroperbenzoic acid afforded the title products (5a-d) as a mixture of two regioisomers (A and B). Isomer A, the resu

Palladium-Catalyzed Phase-Transfer Arylation of Dialkyl Phosphonates

Palladium-catalyzed phase-transfer arylation of dialkyl phosphonates with various iodo- and bromoarenes has been studied. The arylation has also been effected in the absence of ligand. A simple preparative procedure for synthesizing arylphosphonic acids has been developed.