3370-35-2

Basic information

• Product Name: N-HYDROXYMETHYL-STEARAMIDE
• Synonyms: n-(hydroxymethyl)-octadecanamid;N-HYDROXYMETHYL-STEARAMIDE;N-(hydroxymethyl)octadecanamide;N-(HydroxymethyL)-Octadecanamide;Octadecanamide, N-(hydroxymethyl)-;N-(HYDROXYMETHYL)ALKANE(C=17)AMIDE;N-Hydroxymethylstearic acid amide;N-Hydroxymethylstearic amide
• CAS NO: 3370-35-2
• Molecular Formula: C₁₉H₃₉NO₂
• Molecular Weight: 313.52
• EINECS: 222-147-1
• Mol File: 3370-35-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: >107℃
• Boiling Point: 465.9 °C at 760 mmHg
• Flash Point: 235.5 °C
• Appearance: /
• Density: 0.907 g/cm³
• Vapor Pressure: 1.23E-10mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: 2-8°C
• PKA: 13.40±0.10(Predicted)
• CAS DataBase Reference: N-HYDROXYMETHYL-STEARAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-HYDROXYMETHYL-STEARAMIDE(3370-35-2)
• EPA Substance Registry System: N-HYDROXYMETHYL-STEARAMIDE(3370-35-2)

Safety Data

• Hazardous Substances Data: 3370-35-2(Hazardous Substances Data)

Usage

General Description

N-HYDROXYMETHYL-STEARAMIDE is a synthetic chemical compound used as a lubricant and thickening agent in various industries, including cosmetics, personal care products, and industrial applications. It is derived from stearic acid and has a hydroxymethyl group attached to the nitrogen atom. N-HYDROXYMETHYL-STEARAMIDE has a high melting point and is insoluble in water, making it suitable for use in products that require heat resistance and moisture protection. N-HYDROXYMETHYL-STEARAMIDE is known for its ability to improve the viscosity and texture of formulations, as well as its lubricating and emulsifying properties, making it a versatile ingredient in a wide range of products. However, it is important to handle and use this chemical with proper safety precautions due to its potential health hazards.

InChI:InChI=1/C19H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(22)20-18-21/h21H,2-18H2,1H3,(H,20,22)

Synthetic route

formaldehyd (50-00-0) + stearamide (124-26-5) → N-methylol stearamide (3370-35-2)

2-(morpholin-4-yl)ethanol (622-40-2) + N-methylol stearamide (3370-35-2) → N-(2-morpholino-ethoxymethyl)-stearamide

Conditions	Yield
With sodium carbonate

methanol (67-56-1) + N-methylol stearamide (3370-35-2) → N-methoxymethyl-stearamide (66736-61-6)

Conditions	Yield
With sulfuric acid at 50℃;

octanol (111-87-5) + N-methylol stearamide (3370-35-2) → N-octyloxymethyl-stearamide

Conditions	Yield
With hydrogenchloride at 30 - 40℃;
With sulfuric acid
With hydrogenchloride at 30 - 40℃;

2-hydroxyethanesulfonic acid (107-36-8) + N-methylol stearamide (3370-35-2) → 2-(stearoylamino-methoxy)-ethanesulfonic acid

Conditions	Yield
With acetone at 45 - 50℃;

N-methylol stearamide (3370-35-2) + pyridine thiocyanate (30248-54-5) → 1-(stearoylamino-methyl)-pyridinium; thiocyanate

Conditions	Yield
With pyridine

N-methylol stearamide (3370-35-2) + thiourea hydrochloride (37622-18-7, 37622-19-8) → S-(stearoylamino-methyl)-isothiourea; hydrochloride

Conditions	Yield
With methanol at 50 - 60℃;
With ethanol at 50 - 60℃;
With methanol at 50 - 60℃;
With ethanol at 50 - 60℃;

N-methylol stearamide (3370-35-2) → N-ethoxymethyl-stearamide (17419-62-4)

Conditions	Yield
With ethanol; sulfuric acid

N-methylol stearamide (3370-35-2) → (stearoylamino-methyl)-phosphonic acid (16117-20-7)

Conditions	Yield
With tetrachloromethane; acetic acid; phosphorus trichloride beim Erwaermen des Reaktionsprodukts mit 8prozentiger HCl auf 50grad;

N-methylol stearamide (3370-35-2) → bis-stearoylamino-methane (109-23-9)

Conditions	Yield
With mineral acids

N-methylol stearamide (3370-35-2) → 1-(stearoylamino-methyl)-pyridinium; chloride (4261-72-7)

Conditions	Yield
With pyridine; tetrachloromethane; benzenesulfonyl chloride
With pyridine; tetrachloromethane; benzoyl chloride
With pyridine; tetrachloromethane; thionyl chloride

N-methylol stearamide (3370-35-2) + ethylene glycol (107-21-1) → N-(2-hydroxy-ethoxymethyl)-stearamide

Conditions	Yield
With maleic anhydride at 60℃;

N-methylol stearamide (3370-35-2) + mercaptoacetic acid (68-11-1) → (stearoylamino-methylsulfanyl)-acetic acid (102899-77-4)

Conditions	Yield
With acetic acid at 55℃;
With acetic acid methyl ester; sulfuric acid

N-methylol stearamide (3370-35-2) + thiourea (17356-08-0) → S-(stearoylamino-methyl)-isothiourea; acetate

Conditions	Yield
With acetic acid at 50 - 60℃;

N-methylol stearamide (3370-35-2) + isopropyl alcohol (67-63-0) → N-isopropoxymethyl-stearamide

Conditions	Yield
With sulfuric acid

N-methylol stearamide (3370-35-2) + ethanethiol (75-08-1) → N-(ethylsulfanyl-methyl)-stearamide

Conditions	Yield
With hydrogenchloride

N-methylol stearamide (3370-35-2) + benzyl alcohol (100-51-6) → N-benzyloxymethyl-stearamide (66736-58-1)

Conditions	Yield
With trichlorophosphate at 60℃;

N-methylol stearamide (3370-35-2) + butan-1-ol (71-36-3) → N-butoxymethyl-stearamide (66736-56-9)

Conditions	Yield
With sulfuric acid

N-methylol stearamide (3370-35-2) + diethylene glycol (111-46-6) → N-[2-(2-hydroxy-ethoxy)-ethoxymethyl]-stearamide

Conditions	Yield
With ethyl acetate; phosphorus trichloride at 3 - 6℃;

N-methylol stearamide (3370-35-2) + phenol (108-95-2) → N-phenoxymethyl-stearamide

Conditions	Yield
With sulfuric acid

N-methylol stearamide (3370-35-2) + sodium thioglycol ate → (stearoylamino-methylsulfanyl)-acetic acid (102899-77-4)

Conditions	Yield
With water

tetrachloromethane (56-23-5) + N-methylol stearamide (3370-35-2) + acetic acid (64-19-7) + phosphorus trichloride (7719-12-2, 52843-90-0) → (stearoylamino-methyl)-phosphonic acid (16117-20-7)

Conditions	Yield
beim Erwaermen des Reaktionsprodukts mit 8prozentiger HCl auf 50grad;

hydrogenchloride (7647-01-0) + ethanol (64-17-5) + N-methylol stearamide (3370-35-2) + ethanethiol (75-08-1) → N-ethylsulfanylmethyl-stearamide

hydrogenchloride (7647-01-0) + N-methylol stearamide (3370-35-2) + thiourea (17356-08-0) → S-stearoylaminomethyl-isothiourea hydrochloride

Conditions	Yield
at 50 - 55℃;

pyridine (110-86-1) + N-methylol stearamide (3370-35-2) + pyridine thiocyanate (30248-54-5) → stearoylaminomethyl-pyridinium thiocyanate

Conditions	Yield
at 60℃;

N-methylol stearamide (3370-35-2) → stearic acid (57-11-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrachloromethane; acetic acid; phosphorus trichloride / beim Erwaermen des Reaktionsprodukts mit 8prozentiger HCl auf 50grad 2: 70 - 80 °C View Scheme

N-methylol stearamide (3370-35-2) → stearamide (124-26-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid methyl ester; sulfuric acid View Scheme

Upstream product

• 50-00-0 formaldehyd 
• 124-26-5 stearamide 

Downstream Products

• 124-26-5 stearamide 
• 57-11-4 stearic acid 
• 4261-72-7 1-(stearoylamino-methyl)-pyridinium; chloride 
• 109-23-9 bis-stearoylamino-methane 
• 17419-62-4 N-Ethoxymethyl-octadecansaeureamid