33757-42-5

Basic information

• Product Name: N-(quinolin-8-yl)acetamide
• Synonyms: acetamide, N-8-quinolinyl-; N-(8-Quinolinyl)acetamide
• CAS NO: 33757-42-5
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• Mol File: 33757-42-5.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 430.9°C at 760 mmHg
• Flash Point: 214.4°C
• Density: 1.242g/cm³
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: N-(quinolin-8-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(quinolin-8-yl)acetamide(33757-42-5)
• EPA Substance Registry System: N-(quinolin-8-yl)acetamide(33757-42-5)

Safety Data

• Hazardous Substances Data: 33757-42-5(Hazardous Substances Data)

Usage

General Description

N-(quinolin-8-yl)acetamide is a chemical compound with the molecular formula C12H10N2O. It is an amide derivative of quinoline and acetamide, and it is commonly used in organic synthesis and pharmaceutical research. N-(quinolin-8-yl)acetamide has potential applications in medicinal chemistry, particularly in the development of new drugs for various diseases such as cancer and neurodegenerative disorders. N-(quinolin-8-yl)acetamide exhibits diverse biological activities and has been investigated for its antitumor, antifungal, and antibacterial properties. Its structure and properties make it an important building block in the synthesis of novel compounds with potential therapeutic benefits.

Upstream product

• 578-66-5 8-amino quinoline 
• 108-24-7 acetic anhydride 
• 607-35-2 8-nitroquinoline 
• 91-22-5 quinoline 
• 75-36-5 acetyl chloride 
• 190137-71-4 3-phenylquinolin-8-amine 
• 64-19-7 acetic acid 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 33757-46-9 8-(N-propionylamino)quinoline 
• 563-63-3 silver(I) acetate 
• 127-19-5 N,N-dimethyl acetamide 
• 507-09-5 tiolacetic acid 
• 14040-11-0 tungsten hexacarbonyl 

Downstream Products

• 99840-76-3 N-(1,2,3,4-tetrahydroquinolin-8-yl)acetamide 
• 477531-98-9 N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 578-66-5 8-amino quinoline 
• 316-99-4 N-(5-(trifluoromethyl)quinolin-8-yl)acetamide 

Relevant articles and documents

Nickel-Catalyzed Reaction of Benzamides with Bicylic Alkenes: Cleavage of C-H and C-N Bonds

The nickel-catalyzed reaction of aromatic amides that contain an 8-aminoquinoline as a directing group with bicyclic alkenes, such as norbornene and 1,4-dihydro-1,4-epoxynaphthalene, results in the cleavage of both the C-H bond at the ortho-position of th

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Visible-Light-Triggered Decarboxylative Alkylation of 8-Acylaminoquinoline with N -Hydroxyphthalimide Ester

A facile protocol for visible-light-induced decarboxylative radical coupling of NHP esters with 8-aminoquinoline amides is reported, affording a highly efficient approach to synthesize a variety of 2-alkylated or 2,4-dialkylated 8-aminoquinoline derivativ