33788-40-8

Basic information

• Product Name: (E)-ethyl 3-(2-pyridyl)-propenoate
• CAS NO: 33788-40-8
• Molecular Weight: 177.203
• Mol File: 33788-40-8.mol
• Article Data: 50

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 3-(2-pyridyl)-propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 3-(2-pyridyl)-propenoate(33788-40-8)
• EPA Substance Registry System: (E)-ethyl 3-(2-pyridyl)-propenoate(33788-40-8)

Safety Data

• Hazardous Substances Data: 33788-40-8(Hazardous Substances Data)

Upstream product

• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 
• 1121-60-4 pyridine-2-carbaldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 7340-22-9 3-pyridin-2-yl-acrylic acid 
• 64-17-5 ethanol 
• 586-98-1 2-Hydroxymethylpyridine 
• 109-06-8 α-picoline 
• 609-09-6 Diethyl ketomalonate 
• 109-09-1 2-chloropyridine 
• 140-88-5 ethyl acrylate 
• 109-04-6 2-bromo-pyridine 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 131610-03-2 3-(pyridin-2-yl)prop-2-en-1-ol 
• 2740-00-3 indolizidin-3-one 
• 113985-52-7 (E)-3-(pyridin-2-yl)prop-2-en-1-ol 
• 64107-57-9 2-[2-(3-Bromo-pyridin-2-ylmethylsulfanyl)-ethylamino]-5-pyridin-2-ylmethyl-1H-pyrimidin-4-one; hydrobromide 
• 64107-50-2 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-pyridin-2-ylmethyl-1H-pyrimidin-4-one; hydrochloride 
• 129196-83-4 (E)-N-Phenyl-3-(2-pyridyl)propenamide 
• 637012-75-0 3-benzylamino-3-(2-pyridyl)propanol 
• 637012-61-4 ethyl 3-benzylamino-3-(2-pyridyl)propanoate 
• 76132-63-3 (+/-)-3-phenyl-3-(pyridin-2-yl)propionic acid ethyl ester 

Relevant articles and documents

A One-Pot Synthesis of α,β-Unsaturated Esters From Esters

A convenient method for reductive Horner–Wadsworth–Emmons (HWE) olefination is described. The E-selective HWE homologation of various esters to α,β-unsaturated esters was readily achieved and gave the desired products in good-to-moderate yields under mild conditions. The one-pot reaction proceeds through an in situ generated aldehyde, formed via the partial reduction of an ester with lithium diisobutyl-t-butoxyaluminum hydride. The formation of cyclized metal acetal and subsequent decompose to the aldehyde for the olefination was found to be a crucial step in this C2-carbon homologation protocol.

(E)-3-heteroaromatic propyl-2-enoic acid derivative as well as preparation and application thereof

The invention relates to a (E)-3-heteroaromatic propyl-2-enoic acid derivative, and also relates to a preparation method and pharmaceutical application thereof. The compound is a novel Nrf2 activatorand has the effects of resisting oxidative stress, resisting neuritis and enhancing mitochondrial functions and biogenesis by effectively activating an Nrf2 signal path, so that nerve cells are protected, and the compound can be used for treating neurodegenerative diseases and cerebral apoplexy. In addition, the novel Nrf2 activator can also be used to treat autoimmune diseases, diabetes and nephropathy, and other chronic diseases.

One-Pot Synthesis of α,β-Unsaturated Esters, Ketones, and Nitriles from Alcohols and Phosphonium Salts

A general method for the synthesis of α,β-unsaturated esters, ketones, and nitriles is successfully achieved by a one-pot copper-catalyzed oxidation with O 2 in air as oxidant. The solvent mixture of acetonitrile and formamide (1:1) is optimized to ensure the oxidation of alcohols, deprotonation of phosphonium salt, and Wittig reaction occur efficiently in one pot. A broad range of substrates has been explored for this process, including three electron-withdrawing group (CO 2 Et, COPh, CN) functionalized phosphonium salts. They reacted not only with benzylic and heteroaromatic alcohols, but also with aliphatic alcohols, forming the corresponding α,β-unsaturated esters, ketones, and nitriles in moderate to excellent yields.