34059-10-4

Upstream product

• 140-11-4 Benzyl acetate 
• 2038-57-5 3-Phenylpropan-1-amine 
• 1445-45-0 Trimethyl orthoacetate 
• 30684-05-0 3-phenylpropylamine hydrochloride 
• 300-57-2 allylbenzene 
• 108-24-7 acetic anhydride 
• 60-35-5 acetamide 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 108-22-5 Isopropenyl acetate 
• 122-97-4 3-Phenyl-1-propanol 
• 75-05-8 acetonitrile 
• 75-16-1 methylmagnesium bromide 
• 302569-84-2 N-benzyloxycarbonyloxy-3-phenylpropylamine 

Downstream Products

• 27129-74-4 N-nitroso-N-(3-phenyl-propyl)-acetamide 
• 13125-62-7 1-(ethylamino)-3-phenylpropane 
• 223512-49-0 N-(3-(2-formylphenyl)propyl)acetamide 
• 13125-63-8 N-ethyl-3-phenylpropan-1-amine hydrochloride 
• 154669-86-0 N-(3-oxo-3-phenylpropyl)acetamide 
• 23580-89-4 methyl-(3-phenyl-propyl)-amine 
• 53138-68-4 N-methyl-N-(3-phenylpropyl)acetamide 
• 1329563-52-1 N-{3-[4-(3-chloropropionyl)phenyl]propyl}acetamide 
• 1329563-39-4 N-{3-[4-(3-chloropropyl)phenyl]propyl}acetamide 
• 1329562-90-4 sodium {3-[4-(5-acetylsulfanylpentyl)phenyl]propyl}ethyldithiocarbamate 
• 1329562-98-2 sodium {3-[4-(3-acetylsulfanylpropyl)phenyl]propyl}ethyldithiocarbamate 
• 1329563-11-2 {3-[4-(5-acetylsulfanylpentyl)phenyl]propyl}ethylamine 
• 1329563-17-8 {3-[4-(3-acetylsulfanylpropyl)phenyl]propyl}ethylamine 
• 1329563-22-5 {3-[4-(5-chloropentyl)phenyl]propyl}ethylamine 

Relevant academic research and scientific papers

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

ENVIRONMENTALLY-FRIENDLY HYDROAZIDATION OF OLEFINS

The present invention provides processes for the synthesis of organic azides, intermediates for the production thereof, and compositions related thereto.

Direct Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins

We herein report a direct intermolecular anti-Markovnikov hydroazidation method for unactivated olefins, which is promoted by a catalytic amount of bench-stable benziodoxole at ambient temperature. This method facilitates previously difficult, direct addition of hydrazoic acid across a wide variety of unactivated olefins in both complex molecules and unfunctionalized commodity chemicals. It conveniently fills a synthetic chemistry gap of existing olefin hydroazidation procedures, and thereby provides a valuable tool for azido-group labeling in organic synthesis and chemical biology studies.

Design and synthesis of sulfonamidophenylethylureas as novel cardiac myosin activator

To optimize the lead urea scaffold 1 and 2 as selective cardiac myosin ATPase activator, a series of urea derivatives have been synthesized to explore its structure activity relationship. Among them N,N-dimethyl-4-(2-(3-(3-phenylpropyl)ureido)ethyl)benzenesulfonamide (13, CMA = 91.6%, FS = 17.62%; EF = 11.55%), N,N-dimethyl-4-(2-(1-methyl-3-(3-phenylpropyl)ureido)ethyl)benzene sulfonamide (40, CMA = 52.3%, FS = 38.96%; EF = 24.19%) and N,N-dimethyl-4-(2-(3-methyl-3-(3-phenylpropyl)ureido)ethyl)benzenesulfonamide (41, CMA = 47.6%, FS = 23.19%; EF = 15.47%) proved to be efficient to activate the cardiac myosin in vitro and in vivo. Further the % change in ventricular cell contractility at 5 μM of 13 (47.9 ± 3.2), 40 (45.5 ± 2.4) and 41 (63.5 ± 2.2) showed positive inotropic effect in isolated rat ventricular myocytes. The potent compounds 13, 40, 41 were highly selective for cardiac myosin over skeletal and smooth muscle myosin, thus proving them these new urea derivatives is a novel scaffold for discovery of cardiac myosin activators for the treatment of systolic heart failure.

2-(Phenylseleno)ethanesulfon-amide as a novel protecting group for aniline that can be deprotected by a radical reaction

Anilines were protected as 2-(phenylseleno)ethanesulfonanilide (SeES anilide) via sulfonylation by 2-chlorosulfonyl chloride followed by the conjugate addition of benzeneselenol. The SeES anilide was deprotected by radical reduction using tributyltin hydride in the presence of AIBN. The corresponding anilines were obtained in high yields when the hydride and AIBN were added to the system slowly. Since the radical reaction proceeds under neutral conditions, chemoselective deprotection of the SeES group was accomplished. The SeES anilide was stable under various conditions, including some severe conditions.

Bis-arylalkenylalkyl acid compound, and preparation method and application thereof

The invention relates to a bis-arylalkenylalkyl acid compound, and a preparation method and an application thereof. The structure of the compound is represented by the formula I. the definitions of *, R1, R2, R3, n1 and m are as in the specifications and the claims. The bis-arylalkenylalkyl acid compound provided by the invention has relatively high inhibition activity against sensitive strains and resistant strains, and can be used for preparing antibacterial drugs.

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

The present invention relates to a compound having a cardiotonic activating function and a pharmaceutical composition containing the same. The composition comprising the compound according to the present invention is effective in preventing or treating heart failure. In addition, the compound is represented by chemical formula 2 or is pharmaceutically acceptable salt thereof.COPYRIGHT KIPO 2016

Direct Preparation of Amides from Amine Hydrochloride Salts and Orthoesters: A Synthetic and Mechanistic Perspective

The conversion of a wide range of primary and secondary aliphatic and a few arylamine hydrochloride salts to their corresponding acetamides with trimethyl orthoacetate is described. Mechanistic studies using NMR and gas chromatography-mass spectrometry techniques indicate these reactions proceed via an O-methylimidate intermediate that undergoes in situ demethylation by chloride, affording the corresponding acetamides. Synthetically, this reaction represents a practical, high-yielding protocol with a simple workup for the rapid conversion of amine hydrochloride salts to acetamides.

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.COPYRIGHT KIPO 2016

Tandem synthesis of amides and secondary amines from esters with primary amines under solvent-free conditions

An iridium(III)-catalyzed tandem synthesis of amides and amines from esters under solvent-free conditions is described. A commercially available iridium(III) complex, [Cp*IrCl2]2, with sodium acetate showed the best activity for the synthesis of amides and secondary amines. The amide was formed by ester-amide exchange which generates an alcohol in situ which is subsequently transformed to a secondary amine via hydrogen autotransfer. This synthetic protocol with high atom economy generates water as the sole by-product and can afford amides and amines from various esters in a one-pot reaction, expanding the synthetic versatility of ester transformations.