35216-39-8

Basic information

• Product Name: 3-(METHYLSULFONYL)ANILINE
• Synonyms: P-Toluene Suphonamide (PTSA);3-(Methylsulphonyl)aniline;3-Aminophenyl methyl sulphone;3-(methylsulfonyl)Benzenamine;m-(Methylsulfonyl)aniline;3-Aminophenyl methyl sulfone;3-Methylsulfonylphenylamine
• CAS NO: 35216-39-8
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• Mol File: 35216-39-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 72 °C
• Boiling Point: 403.3°C at 760 mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.282g/cm³
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.66±0.10(Predicted)
• CAS DataBase Reference: 3-(METHYLSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(METHYLSULFONYL)ANILINE(35216-39-8)
• EPA Substance Registry System: 3-(METHYLSULFONYL)ANILINE(35216-39-8)

Safety Data

• Hazardous Substances Data: 35216-39-8(Hazardous Substances Data)

Usage

Uses

3-(Methylsulfonyl)aniline is used in the preparation of substituted pyrazolopyrimidines as IRAK4 kinase inhibitors.

InChI:InChI=1/C7H9NO2S/c1-11(9,10)7-4-2-3-6(8)5-7/h2-5H,8H2,1H3

Upstream product

• 20277-69-4 sodium methansulfinate 
• 591-19-5 m-Bromoaniline 
• 124-63-0 methanesulfonyl chloride 
• 626-01-7 3-Iodoaniline 
• 19614-16-5 2-bromo-1-(methylsulfanyl)benzene 
• 3937-95-9 3-Nitrophenylsulfonylessigsaeure 
• 1783-81-9 3-methylmercaptoaniline 
• 2976-32-1 1-methanesulfonyl-3-nitro-benzene 
• 33951-33-6 1-bromo-2-(methylsulfonyl)benzene 
• 13257-95-9 3-nitrobenzenesulfinic acid 
• 3112-85-4 methylphenylsulfonate 

Downstream Products

• 14763-61-2 3-(methylsulfonyl)phenol 
• 22821-75-6 3-(methylsulfonyl)benzonitrile 
• 43032-67-3 1-methanesulfonyl-3-methoxy-benzene 
• 522599-89-9 5-(4-chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (3-methanesulfonyl-phenyl)-amide 
• 503182-92-1 4-[(3-methanesulfonylphenyl)hydrazono]-4H-pyrazole-3,5-diamine 
• 159177-51-2 3-(3-methanesulphonyl)phenyl-4-thiazolidinone 
• 1237785-40-8 C₂₉H₃₉N₇O₄SSi 
• 1020815-11-5 C₁₄H₁₉N₃O₂S 
• 1020815-06-8 C₁₁H₁₃N₃O₂S 
• 1401461-35-5 methyl 3-(7-(3-(methylsulfonyl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate 
• 1401461-37-7 3-[7-(3-Methanesulfonyl-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-benzoic acid 
• 1401462-10-9 5-chloro-N-(3-(methylsulfonyl)phenyl)thiazolo[5,4-d]pyrimidin-7-amine 
• 1400220-85-0 1-(3-methanesulfonyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea 
• 1366128-02-0 2,4-difluoro-N-[2-(methyloxy)-5-(2-({[4-(methyloxy)phenyl]methyl}amino)-3-{[3-(methylsulfonyl)phenyl]amino}-6-quinolinyl)-3-pyridinyl]benzenesulfonamide 

Relevant articles and documents

WDR5-MYC INHIBITORS

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

Aromatic C-H amination in hexafluoroisopropanol

We report a direct radical aromatic amination reaction that provides unprotected anilines with an improvement in the substrate scope compared to prior art. Hydrogen bonding by the solvent hexafluoroisopropanol to anions of cationic species is responsible for increased reactivity and can rationalize the enhancement in substrate scope. Our findings may have bearings on radical additions to arenes for direct C-H functionalization in general.

A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions

The amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing the formation of a wide range of (hetero)aryl sulfones from the corresponding (hetero)aryl halides at considerably low catalytic loadings. The coupling of (hetero)aryl iodides and sodium methanesulfinate proceeds at room temperature with only 0.5 mol % CuI and ligand, representing the first example for Cu-catalyzed arylation at both low catalytic loading and room temperature.