22821-75-6

Basic information

• Product Name: 4,6-DIMETHOXY-2-PIPERIDIN-4-YLPYRIMIDINE
• Synonyms: 4,6-DIMETHOXY-2-PIPERIDIN-4-YLPYRIMIDINE;3-(Methylsulphonyl)benzonitrile 98%;3-Cyanophenyl methyl sulphone;Benzonitrile,3-(Methylsulfonyl)-;4,6-Dimethoxy-2-(4-piperidinyl)pyrimidine;3-(Methylsulphonyl)benzonitrile98%
• CAS NO: 22821-75-6
• Molecular Formula: C₈H₇NO₂S
• Molecular Weight: 181.21
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 22821-75-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 48-51
• Boiling Point: 378.1 °C at 760 mmHg
• Flash Point: 182.5 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 6.45E-06mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,6-DIMETHOXY-2-PIPERIDIN-4-YLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHOXY-2-PIPERIDIN-4-YLPYRIMIDINE(22821-75-6)
• EPA Substance Registry System: 4,6-DIMETHOXY-2-PIPERIDIN-4-YLPYRIMIDINE(22821-75-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 22821-75-6(Hazardous Substances Data)

Usage

General Description

4,6-Dimethoxy-2-piperidin-4-ylpyrimidine is a chemical compound with the molecular formula C12H18N4O2. It is a heterocyclic compound containing a pyridine ring and a piperidine ring, both of which are substituted with methoxy groups. 4,6-DIMETHOXY-2-PIPERIDIN-4-YLPYRIMIDINE has potential pharmaceutical applications, as it may have biological activity related to its structure. However, further research is needed to fully understand its properties and potential uses in the pharmaceutical industry.

InChI:InChI=1/C8H7NO2S/c1-12(10,11)8-4-2-3-7(5-8)6-9/h2-5H,1H3

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Relevant articles and documents

Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers

We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.

An investigation by means of correlation analysis into the mechanisms of oxidation of aryl methyl sulfides and sulfoxides by dimethyldioxirane in various solvents

Relative rate constants have been measured for the oxidation of aryl methyl sulfides and sulfoxides by dimethyldioxirane in acetone, in mixtures of acetone with aprotic co-solvents of both higher and lower relative permittivity, and in aqueous acetone mixtures. Correlation analyses of the effects of substituents in the different solvents show that, with one exception, reactions take place via a single step mechanism in which the formation of the new SO bond and the elimination of acetone occur concertedly. The exception was oxidation of the sulfides in aqueous acetone containing the highest proportion of water of those studied (20% v/v). Here, the behaviour of the reaction is consistent with a two-step mechanism in which the oxidant reversibly attacks the sulfide to form an open-chain sulfonium betaine that subsequently fragments to sulfoxide and acetone. There is no evidence for the participation of an intermediate dioxathietane as has been found in the case of sulfide oxidations by (trifluoromethyl)methyldioxirane in CH2Cl2 and similar aprotic solvents. It is not justified to generalise a mechanism involving a betaine, with or without a derived dioxathietane, to the reactions of dimethyldioxirane in acetone. This journal is The Royal Society of Chemistry.

Pyrimidine derivatives for the treatment of abnormal cell growth

The present invention relates to a compound of the formula 1 wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.