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36282-47-0

36282-47-0

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36282-47-0 Usage

Description

Different sources of media describe the Description of 36282-47-0 differently. You can refer to the following data:
1. cis-Tramadol (Item No. 15919) is an analytical reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
2. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is a certified reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

White Solid

Uses

cis-Tramadol is an analgesic that activates the μ-opioid receptor (IC50 = 7.6 μM). It also inhibits serotonin and norepinephrine reuptake and blocks voltage-gated sodium channels. This product is intended for forensic and research applications.[Cayman Chemical]

Check Digit Verification of cas no

The CAS Registry Mumber 36282-47-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,2,8 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 36282-47:
(7*3)+(6*6)+(5*2)+(4*8)+(3*2)+(2*4)+(1*7)=120
120 % 10 = 0
So 36282-47-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m0./s1

36282-47-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Tramadol Hydrochloride

1.2 Other means of identification

Product number -
Other names Tramadol hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36282-47-0 SDS

36282-47-0Relevant articles and documents

Continuous-Flow Synthesis of Tramadol from Cyclohexanone

Monos, Timothy M.,Jaworski, Jonathan N.,Stephens, John C.,Jamison, Timothy F.

, p. 1888 - 1893 (2020/11/24)

A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. 'Flash' reactivity between meta-methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g°h -1) sustained over 56 reactor volumes. A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol.

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server

Fitzpatrick, Daniel E.,Maujean, Timothé,Evans, Amanda C.,Ley, Steven V.

supporting information, p. 15128 - 15132 (2018/10/31)

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.

COMPOSITIONS AND METHODS FOR OVERCOMING RESISTANCE TO TRAMADOL

-

Paragraph 0210, (2013/03/26)

There is disclosed a composition for oral administration of O-desmethyltramadol. There is further disclosed a method for treating disorders modulated by at least opiate receptor activity or monoamine activity, including acute and chronic pain, comprising administering a pharmaceutical formulation comprising O-desmethyltramadol. Compositions and methods are also provided that are effective for overcoming resistance to tramadol in patients.