38359-28-3Relevant academic research and scientific papers
Aminofluorene-Mediated Biomimetic Domino Amination-Oxygenation of Aldehydes to Amides
Ghosh, Santanu,Jana, Chandan K.
supporting information, p. 5788 - 5791 (2016/11/29)
A conceptually novel biomimetic strategy based on a domino amination-oxygenation reaction was developed for direct amidation of aldehydes under metal-free conditions employing molecular oxygen as the oxidant. 9-Aminofluorene derivatives acted as pyridoxamine-5′-phosphate equivalents for efficient, chemoselective, and operationally simple amine-transfer oxygenation reaction. Unprecedented RNH transfer involving secondary amine to produce secondary amides was achieved. In the presence of 18O2, 18O-amide was formed with excellent (95%) isotopic purity.
Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: Discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range
Teodori, Elisabetta,Dei, Silvia,Quidu, Patricia,Budriesi, Roberta,Chiarini, Alberto,Garnier-Suillerot, Arlette,Gualtieri, Fulvio,Manetti, Dina,Romanelli, Maria Novella,Scapecchi, Serena
, p. 1687 - 1697 (2007/10/03)
On the basis of the results obtained in previous research, three series of compounds (A-C), derived from verapamil, were designed and synthesized to obtain drugs able to revert multidrug resistance (MDR), an acquired resistance that frequently impairs cancer chemotherapy. The ability of the obtained compounds to revert MDR was evaluated on anthracycline-resistant erythroleukemia K 562 cells, measuring the uptake of THP-adriamycin (pirarubicin) by continuous spectrofluorometric monitoring of the decrease of the fluorescence signal of the anthracycline at 590 nm (λ(ex) = 480 nm), after incubation with cells. Cardiovascular activity, which is responsible for unwanted side effects, was also evaluated. The results obtained show that many of the compounds studied are potent reverters of MDR and are endowed with reduced cardiovascular activity. One of the compounds (7, MM36) presents a pharmacological profile (unprecedented nanomolar potency, high reversal of MDR, low cardiovascular activity) that makes it a promising drug candidate to treat MDR and a useful tool for studying P-glycoprotein.
Mechanisms of solvent- and base-promoted imine-forming elimination reactions
Meng, Qingshui,Thibblin, Alf
, p. 1224 - 1229 (2007/10/03)
Solvolysis of 9-(N-chloro-N-methylamino)fluorene (1-Cl) in 25 vol % acetonitrile in water gives the imine fluorenylidenemethylamine (3) as the sole product. The kinetic deuterium isotope effect was measured with the deuterated analogue (9-2H)-9
