40711-33-9

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate is used as an intermediate in the synthesis of various pharmaceuticals for its potential pharmacological properties. It contributes to the development of therapeutic agents with anticonvulsant and analgesic properties, indicating its potential in treating medical conditions that require such effects.
Used in Agrochemical Industry:
In the agrochemical sector, ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate serves as a key intermediate in the production of agrochemicals. Its biological activities make it a candidate for developing compounds that can be used in agricultural applications, such as pest control or plant protection.
Used as a Building Block in Organic Synthesis:
Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate is also utilized as a building block in the synthesis of other organic compounds. Its unique structure allows it to be a versatile component in creating a wide range of chemical entities for various applications, including but not limited to, the development of new materials, dyes, or other specialty chemicals.

Upstream product

• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 64-17-5 ethanol 
• 563-41-7 semicarbazide hydrochloride 
• 127-09-3 sodium acetate 
• 108-56-5 diethyl oxaloacetate 
• 3702-98-5 ethyl 4,4,4-trichloroacetoacetate 
• 25117-86-6 diazo-succinic acid diethyl ester 
• 10302-94-0 (Z)-2-chloro-2-butenedioic acid, diethyl ester 
• 302-01-2 hydrazine 
• 37832-55-6 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 1192313-30-6 ethyl 1-(2-oxo-2-m-tolylethyl)-3-(3-(piperidin-1-yl)propoxy)-1H-pyrazole-5-carboxylate 
• 628331-20-4 3-benzyloxy-1H-pyrazole-5-carboxylic acid methyl ester 
• 52867-49-9 1-benzyl-3-hydroxy-5-methoxycarbonyl-1H-pyrazole 
• 1192313-86-2 1,1-dimethylethyl 4-[(5-[(ethyloxy)carbonyl]-1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-1H-pyrazol-3-yl)oxy]-1-piperidinecarboxylate 
• 1192313-58-8 ethyl 3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-1-H-pyrazole-5-carboxylate 
• 1192313-22-6 ethyl 1-[2-(3-chlorophenyl)-2-oxoethyl]-3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1H-pyrazole-5-carboxylate 
• 66483-27-0 5‐oxo‐2,5‐dihydro‐1H‐pyrazole‐3‐carbohydrazide 
• 37832-55-6 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

THIENO[2,3-C]PYRANS AS CFTR MODULATORS

The present invention discloses compounds according to Formula I: Wherein R is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS

The present invention discloses compounds according to Formula I: wherein R1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

A novel method for the synthesis of 3,4-disubstitutedpyrrole-2,5- dicarboxylates from hydrazones derived from α-diazo esters

Hydrazones obtained from α-diazo esters were converted to pyrroles when heated with thionyl chloride in alcohol. Among hydrazones, those substituted with a benzene ring on the β-carbon to the ester are likely to give pyrroles in good yields.

Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: Novel, potent, and selective series of Vasopressin1b receptor antagonists

Novel series of pyrrole-pyrazinone and pyrazole-pyrazinone have been identified as potent and selective Vasopressin1b receptor antagonists. Exploration of the substitution pattern around the core of these templates allowed generation of compounds with high inhibitory potency at the Vasopressin1b receptor, including examples that showed good selectivity with respect to Vasopressin1a, Vasopressin2, and Oxytocin receptor subtypes.

PYRAZOLO [1,5-A]PYRAZINE DERIVATIVE AS ANTAGONISTS OF V1B RECEPTORS

The present invention relates to novel compounds of formula (I) or salts thereof: wherein R is -X-[CH2]n CR4R5 -Y; or a group G; G is one of the groups selected from the list consisting of G1, G2, G3, G4, G5, G6, G7, G8, G9, G10, G11 and G12, and the rest

Benzimidazole derivatives and their use as KDR kinase protein inhibitors

The invention discloses and claims benzimidazole compounds of formula (I): wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl or a saturated 5- or 6-membered monocyclic heterocyclic radical or a b