4170-30-3 Usage
Description
Crotonaldehyde is a clear, colorless to straw-colored liquid with
a strong suffocating odor. It is highly flammable and produces
toxic vapors at room temperature. Crotonaldehyde is found
naturally in emissions of some vegetation and volcanoes; many
foods contain crotonaldehyde in small amounts. Crotonaldehyde
is an important environmental pollutant. It is formed
during combustion of carbon-containing fuels and other
materials. Lipari et al. calculated an emission of 140–2700
metric tons of crotonaldehyde per year in the United States due
to burning of wood in fireplaces, based on the consumption of
firewood. Concentrations of 0.02–17 mgm-3 were measured in
automobile exhausts; however, surprisingly low concentrations
of crotonaldehyde in the range of 1.1–2.1 μgm-3 were found
near highways at a distance of 1 m. In addition, relatively high
amounts of 72–228μg of crotonaldehyde are formed from each
smoked cigarette. Crotonaldehyde is evidently also formed
during biological degradation of organic material such as
plants. In exhausts of house garbage compost plants, amounts
of 2.9 mgm-3 were measured. Strongly varying concentrations
of crotonaldehyde are reported to occur in food, e.g., in fish
(71–1000 μg kg-1), in meat (10–270 μg kg-1), and in fruits and
vegetables (1–100 μg kg-1). Crotonaldehyde was also found in
alcoholic beverages like wine (0.3–1.24 mg l-1) or whisky (30–
210 μg l-1). Crotonaldehyde is an important industrial chemical
(e.g., for the synthesis of tocopherol (vitamin E), the food
preservative sorbic acid, and the solvent 3-methylbutanol), but
it is also a contaminant and by-product in various chemical
processes.
Chemical Properties
Different sources of media describe the Chemical Properties of 4170-30-3 differently. You can refer to the following data:
1. colourless liquid
2. Crotonaldehyde is water-white (turns paleyellow on contact with air) with an irritating, pungent, suffocating odor.
Physical properties
Clear, colorless to straw-colored liquid with a pungent, irritating, suffocating odor. An odor
threshold concentration of 23 ppbv was reported by Nagata and Takeuchi (1990). Katz and Talbert
(1930) reported experimental detection odor threshold concentrations ranged from 180 to 570
μg/m3 (63 to 200 ppbv).
Uses
Different sources of media describe the Uses of 4170-30-3 differently. You can refer to the following data:
1. manufacture of butyl alcohol, butyraldehyde, methoxybutyraldehyde, sorbic acid, maleic acid, crotonic acid, crotyl alcohol. In polymer chemistry: manufacture of resins and polyvinyl acetals, solvent for polyvinyl chloride, rubber antioxidant, increases rubber strength with ketones. In preparation of insecticides and fertilizers. In production of flavors.
2. Crotonaldehyde is used in organic synthesis, in the manufacture
of butyl alcohol and butyraldehyde, and as a warning
agent in fuel gases. It is also used in the manufacture of nbutanol
and sorbic acid as well as in the production of
flavoring agents, surface-active agents, textiles, and insecticidal
compounds.
3. Intermediate for the production of
scorbic acid; formerly used in the manufacture
of n-butyl alcohol; formed during the combustion
of fossil fuels
Definition
Commercial crotonaldehyde is the trans isomer.
General Description
A clear colorless to straw colored liquid with a penetrating pungent odor. Flash point 55°F. Density 7.1 lb / gal. Very toxic by inhalation. May polymerize with the release of heat under exposure to heat or contamination. If polymerization takes place inside a container, the container may rupture violently. Less dense than water. Vapors heavier than air.
Air & Water Reactions
Highly flammable. Slightly soluble in water.
Reactivity Profile
CROTONALDEHYDE can react violently with strong oxidizing reagents, e.g., reaction with conc. nitric acid leads to instantaneous ignition [Andrussow, L., Chim. Ind. (Paris), 1961, 86, p. 542]. In contact with strong acids or bases CROTONALDEHYDE will undergo an exothermic condensation reaction. Reaction with 1,3-butadiene is particularly violent [Greenlee, K. W., Chem. Eng. News, 1948, 26, p. 1985]. Crotonaldehyde may rapidly polymerize with ethyl acetoacetate (Soriano, D.S. et al. 1988. Journal of Chemical Education 65:637.).
Hazard
An animal carcinogen. Irritating to
eyes, skin, and upper respiratory tract irritant.
Flammable, dangerous fire risk. Explosive limits
in air 2.9–15.5% by volume. Questionable carcinogen.
Health Hazard
CROTONALDEHYDE is an extreme eye, respiratory, and skin irritant and can cause corneal damage. A 15 minute exposure at 4.1 ppm is highly irritating to the nose and upper respiratory tract and causes tearing. Brief exposure at 45 ppm proved very disagreeable with prominent eye irritation.
Fire Hazard
Flammable/combustible material; may be ignited by heat, sparks or flames. Vapor may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Readily converted by oxygen to hazardous peroxides and acids and is incompatible with caustics, ammonia, organic amines, mineral acids, and strong oxidizers. Readily resinifies to dimer when pure and slowly oxidizes to crotonic acid. Altered by light and air. Hazardous polymerization may occur. Polymerization may take place at high temperatures.
Safety Profile
Suspected carcinogen
with experimental carcinogenic data. Poison
by ingestion and inhalation. Mutation data
reported. An eye, skin, and mucous
membrane irritant. A lachrymating material
that can cause corneal burns and is very
dangerous to the eyes. Caution: Keep away
from heat and open flame. Keep container
closed. Use with adequate ventilation.
Extremely irritating to eyes, slim, mucous
membranes. When necessary, the
lachrymatory effect of the vapors may be
counteracted by ammonia fumes.
Dangerous fire hazard when exposed to heat
or flame; can react with oxidizing materials.
To fight fire, use alcohol foam, CO2, dry
chemical. Reacts violently with 1,3
butadlene. Violent hypergolic reaction with
concentrated nitric acid. When heated to
decomposition it emits acrid smoke and
fumes. See also ALDEHYDES.
Carcinogenicity
Similar to acrolein, crotonaldehyde
is suspected of having tumorigenic activity and
of involvement in the metabolism of N-nitrosopyrrolidine
. Nevertheless, it has been proven that crotonaldehyde
does have a carcinogenic effect on rats. Indeed,
crotonaldehyde and nitrosopyrrolidine (a metabolite of
crotonaldehyde) induced neoplastic lesions in the liver,
hepatocellular carcinomas, neoplastic nodules, and liver
damage when administered orally to rats over long periods
of time.
Source
Reported in gasoline-powered automobile exhaust at concentrations ranging from 100 to
900 ppb (quoted, Verschueren, 1983).
Gas-phase tailpipe emission rates from California Phase II reformulated gasoline-powered
automobiles with and without catalytic converters were 1.17 and 114 mg/km, respectively
(Schauer et al., 2002).
Schauer et al. (2001) measured organic compound emission rates for volatile organic
compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds
from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission
rates of crotonaldehyde were 276 mg/kg of pine burned, 177 mg/kg of oak burned, and 198 mg/kg
of eucalyptus burned.
Environmental fate
Biological. Heukelekian and Rand (1955) reported a 10-d BOD value of 1.30 g/g which is
56.8% of the ThOD value of 2.29 g/g.
Chemical/Physical. Slowly oxidizes in air forming crotonic acid (Windholz et al., 1983). At
elevated temperatures, crotonaldehyde may polymerize (NIOSH, 1997).
Crotonaldehyde undergoes addition of water across the CH=CH bond yielding 3-
hydroxybutanal (Kollig, 1995).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in effluent
concentration of 544 mg/L. The adsorbability of the carbon used was 92 mg/g carbon (Guisti et
al., 1974).
Toxicity evaluation
Crotonaldehyde (steric form not reported) has been identified
as a volatile emission product from the arboreous plant
Chinese arborvitae. It has also been detected in gases emitted
from volcanoes. (E)-Crotonaldehyde is emitted to the atmosphere
from the combustion of wood and in exhaust from
gasoline and diesel engines. It is also released to the environment
from tobacco smoke, polymer combustion, and turbine
exhaust.
(E)-Crotonaldehyde has been detected in drinking water
and wastewater, and in human milk and expired air. If released
to soil, (E)-crotonaldehyde will have very high mobility.
Volatilization of (E)-crotonaldehyde may be important from
moist and dry soil surfaces. Biodegradation studies suggest that
(E)-crotonaldehyde may be biodegradable in soil and water,
especially in anaerobic conditions. (E)-Crotonaldehyde readily
polymerizes; therefore, if it is released to soil or water in a spill
situation, a significant fraction may polymerize. If released to
water, (E)-crotonaldehyde may not adsorb to suspended solids
and sediment.
Check Digit Verification of cas no
The CAS Registry Mumber 4170-30-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,7 and 0 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4170-30:
(6*4)+(5*1)+(4*7)+(3*0)+(2*3)+(1*0)=63
63 % 10 = 3
So 4170-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O/c1-2-3-4-5/h2-4H,1H3/b3-2-
4170-30-3Relevant articles and documents
Method for preparing crotonaldehyde from ethanol
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Paragraph 0019-0048, (2021/06/13)
The invention relates to a method for preparing crotonaldehyde from ethanol. The method comprises the following steps of firstly, dehydrogenating ethanol into acetaldehyde by using a metal-loaded semiconductor photocatalyst under illumination, then carrying out aldol condensation under base catalysis, and finally dehydrating under a heating condition to form crotonaldehyde. The method starts from ethanol and has the advantages of wide raw material sources, mild reaction conditions and the like.
Rapid, chemoselective and mild oxidation protocol for alcohols and ethers with recyclable N-chloro-N-(phenylsulfonyl)benzenesulfonamide
Badani, Purav,Chaturbhuj, Ganesh,Ganwir, Prerna,Misal, Balu,Palav, Amey
supporting information, (2021/06/03)
Chlorine is the 20th most abundant element on the earth compared to bromine, iodine, and fluorine, a sulfonimide reagent, N-chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) was identified as a mild and selective oxidant. Without activation, the reagent was proved to oxidize primary and secondary alcohols as well as their symmetrical and mixed ethers to corresponding aldehydes and ketones. With recoverable PS-TEMPO catalyst, selective oxidation over chlorination of primary and secondary alcohols and their ethers with electron-donating substituents was achieved. The reagent precursor of NCBSI was recovered quantitatively and can be reused for synthesizing NCBSI.
Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale
Mayer, Robert J.,Hampel, Nathalie,Ofial, Armin R.
supporting information, p. 4070 - 4080 (2021/01/29)
A quantitative Lewis acidity/basicity scale toward boron-centered Lewis acids has been developed based on a set of 90 experimental equilibrium constants for the reactions of triarylboranes with various O-, N-, S-, and P-centered Lewis bases in dichloromethane at 20 °C. Analysis with the linear free energy relationship log KB=LAB+LBB allows equilibrium constants, KB, to be calculated for any type of borane/Lewis base combination through the sum of two descriptors, one for Lewis acidity (LAB) and one for Lewis basicity (LBB). The resulting Lewis acidity/basicity scale is independent of fixed reference acids/bases and valid for various types of trivalent boron-centered Lewis acids. It is demonstrated that the newly developed Lewis acidity/basicity scale is easily extendable through linear relationships with quantum-chemically calculated or common physical–organic descriptors and known thermodynamic data (ΔH (Formula presented.)). Furthermore, this experimental platform can be utilized for the rational development of borane-catalyzed reactions.
