41840-95-3Relevant academic research and scientific papers
Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2, 1, b]-benzothiazole derivatives
Malik, Jitender K.,Noolvi, Malleshappa N.,Manvi, Fakkirappa V.,Nanjwade,Patel, Harun M.,Manjula,Rao, Mallikarjuna C.,Barve, Ashutosh
experimental part, p. 717 - 724 (2012/04/05)
A novel series of substituted diaryl imidazo[2, 1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted a-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.
Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2,1,b]-benzothiazole derivatives
Malik, Jitender K.,Noolvi, Malleshappa N.,Manvi, Fakkirappa V.,Nanjwade,Patel, Harun M.,Manjula,Mallikarjuna Rao,Barve, Ashutosh
experimental part, p. 717 - 724 (2012/05/20)
A novel series of substituted diaryl imidazo[2,1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted α-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.
Pd-catalyzed synthesis of α-aryl ketones through couplings of α-arylacetyl chlorides with triarylbismuths as multi-coupling nucleophiles
Rao, Maddali L.N.,Giri, Somnath,Jadhav, Deepak N.
experimental part, p. 6133 - 6138 (2010/02/27)
The cross-coupling reaction of α-arylacetyl chlorides with triarylbismuths was studied under Pd-catalyzed conditions. The reaction was found to be facile under the established protocol and furnished high yields of α-aryl ketones in short reaction times. T
An efficient and time saving microwave-assisted selenium dioxide oxidation of 1,2-diarylethanones
Shirude,Patel,Giridhar,Yadav
, p. 1080 - 1085 (2007/10/03)
Selenium dioxide oxidation of 1,2-diarylethanones to corresponding diones by conventional method takes upto 8 hr. The same oxidation under microwave radiations using dimethylsulfoxide as solvent reduces the reaction time considerably (30 to 90 sec). The method reported is efficient and time saving.
Nickel catalysed electrosynthesis of ketones from organic halides and iron pentacarbonyl. Part 2: Unsymmetrical ketones
Dolhem, Eric,Barhdadi, Rachid,Folest, Jean Claude,Nédelec, Jean Yves,Troupel, Michel
, p. 525 - 529 (2007/10/03)
Unsymmetrical aryl-benzyl or aryl-alkyl ketones are obtained by electrolysing in an undivided cell a DMF solution containing two organic halides, iron pentacarbonyl and a catalytic amount of a nickel-2,2′-bipyridine complex.
Antifungal agents. 5. Chloro and amino derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane with potent antifungal activities
Artico, M.,Massa, S.,Santo, R. Di,Costi, R.,Retico, A.,et al.
, p. 715 - 720 (2007/10/02)
Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp.In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole.Structure-activity relationships of the new imidazole antifungal agents are discussed.antifungal agents/estrogen-like imidazoles/1,2-diaryl-1-(1H-imidazol-1-yl)ethane derivatives
