41848-51-5Relevant academic research and scientific papers
Synthetic method for Alpha-bit naphthenic-substituted ketone compound
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Paragraph 0056; 0057; 0058, (2017/10/26)
The invention discloses a synthetic method for an Alpha-bit naphthenic-substituted ketone compound, and belongs to the technical field of the organic synthesis. The technical solution of the synthetic method comprises the following steps: mixing a ketone compound and naphthenic hydrocarbon or dissolving in an organic solvent, reacting in the existence of microwave radiation and a radical initiator in 140-170 DEG C of the temperature, to obtain a target product of the Alpha-bit naphthenic-substituted ketone compound. According to the synthetic method, the ketone compound and the simple naphthenic hydrocarbon are used as the raw materials, and the Alpha-bit naphthenic-substituted ketone compound is obtained by a cross dehydrogenation coupled reaction. The method has the advantages of cheap and simple raw materials, short reaction time, no metal catalysis, environmental protection and high atom economy, and is suitable for the industrial production.
Alkylation of carbonyl compounds in water: Formation of C-C and C-O bonds in the presence of surfactants
Cerichelli, Giorgio,Cerritelli, Simona,Chiarini, Marco,De Maria, Paolo,Fontana, Antonella
, p. 5204 - 5210 (2007/10/03)
The formation of C-C and C-O bonds by the reaction of enolate intermediates with electrophilic substrates commonly requires strong bases, aprotic solvents and very low temperatures. A way of performing the same reactions with sodium hydroxide at moderate temperatures in aqueous surfactant solutions is presented. Different halides, ketones and surfactants (cationic, zwitterionic and anionic) have been used. The results obtained show that the amount of ketone alkylation is much higher and that the reactions are faster in the presence than in the absence of surfactant aggregates. The hydrolysis of the halide is minimised in the presence of cationic or zwitterionic surfactants.
