4249-64-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(diethylamino)-1-phenylethanol is used as a precursor in the synthesis of various medications and drugs. Its role in the pharmaceutical industry is crucial for the development of new therapeutic agents, contributing to the advancement of medical treatments.
Used as a Chiral Auxiliary:
In the field of organic chemistry, 2-(diethylamino)-1-phenylethanol is utilized as a chiral auxiliary in the asymmetric synthesis of organic compounds. This application is significant for enhancing the selectivity and yield of enantioselective reactions, which is essential for producing pharmaceuticals with desired stereochemistry.
Used in Fragrance and Flavor Production:
Owing to its pleasant aroma, 2-(diethylamino)-1-phenylethanol may have potential applications in the fragrance and flavor production industry. It can be used to create or enhance the scent and taste profiles of various consumer products, such as perfumes, cosmetics, and food items.
Safety Considerations:
It is important to handle 2-(diethylamino)-1-phenylethanol with care, as it can be hazardous if not used properly. Proper safety measures should be taken during its production, storage, and application to ensure the well-being of individuals and the environment.

Upstream product

• 96-09-3 styrene oxide 
• 109-89-7 diethylamine 
• 4061-29-4 N,N-diethylphenacylamine 
• 75-11-6 diiodomethane 
• 100-52-7 benzaldehyde 
• 74-95-3 1,1-dibromomethane 
• 125582-78-7 C₁₀H₂₅NPb 
• 64-17-5 ethanol 
• 532-27-4 1-chloroacetophenone 
• 25726-04-9 phenylglyoxylyl chloride 
• 100-42-5 styrene 
• 70-11-1 α-bromoacetophenone 
• 6274-12-0 diethylamine hydrobromide 
• 4402-32-8 1-diethylamino-2-propanol 

Downstream Products

• 25314-87-8 α-Diaethylaminomethylbenzylbenzoat 
• 6407-18-7 N,N-Diaethyl-2-brom-2-phenyl-aethylamin 
• 33551-70-1 β-Diaethylamino-α-fluoro-aethylbenzol 
• 53915-51-8 4-nitro-benzoic acid-(2-diethylamino-1-phenyl-ethyl ester) 

Relevant academic research and scientific papers

Tb2(WO4)3@N-GQDs-FA as an efficient nanocatalyst for the efficient synthesis of β-aminoalcohols in aqueous solution

In the current study, Tb2(WO4)3@N-(GQDs) modified with folic acid (FA) was synthesized during the chemical reaction of terbium (III) tungstate nanoparticles with nitrogen doped graphene quantum dots (N-GQDs) and introduced

Process for preparing beta-aminoalcohol from terminal olefin

The invention provides a method for preparing beta-aminoalcohol from terminal olefin. The method comprises the following steps: with the terminal olefin as a raw material, adding dibromohydantoin, conducting stirring, and then adding organic amine to obtain corresponding beta-aminoalcohol. The method has the advantages of mild conditions, easy operation, cheap raw materials, and wide application prospect.

Photoinduced Olefin Diamination with Alkylamines

Vicinal diamines are ubiquitous materials in organic and medicinal chemistry. The direct coupling of olefins and amines would be an ideal approach to construct these motifs. However, alkene diamination remains a long-standing challenge in organic synthesis, especially when using two different amine components. We report a general strategy for the direct and selective assembly of vicinal 1,2-diamines using readily available olefin and amine building blocks. This mild and straightforward approach involves in situ formation and photoinduced activation of N-chloroamines to give aminium radicals that enable efficient alkene aminochlorination. Owing to the ambiphilic nature of the β-chloroamines produced, conversion into tetra-alkyl aziridinium ions was possible, thus enabling diamination by regioselective ring-opening with primary or secondary amines. This strategy streamlines the preparation of vicinal diamines from multistep sequences to a single chemical transformation.

Terbium–organic framework as heterogeneous Lewis acid catalyst for β-aminoalcohol synthesis: Efficient, reusable and green catalytic method

A terbium–organic framework (Tb-MOF) was prepared using a previously reported procedure. Tb-MOF was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction and surface area analysis. Tb-MOF was e

Solid lithium perchlorate as a powerful catalyst for the synthesis of β-aminoalcohols under solvent-free conditions

Lithium perchlorate catalyzed the ring opening of epoxides with amines to provide the corresponding β-aminoalcohols in excellent yields with high regioselectivity. The reaction proceeds rapidly under mild and neutral conditions and worked well with primary, secondary, aliphatic, aromatic, and hindered amines in short times at room temperature, in the absence of solvent.

Ring Opening Reactions of Epoxides Catalyzed by Samarium Iodides

SmI2(THF)2 catalyzes the ring opening of epoxides by trimethylsilylazide, trimethylsilylcyanide and primary and secondary amines.High regioselectivities are observed in specific cases.

AMINOLEAD COMPOUNDS AS A NEW REAGENT FOR REGIOSELECTIVE RING OPENING OF EPOXIDES

Regioselective ring opening of epoxides is accomplished by using aminolead compounds; the reagents attack the less hindered carbon of epoxide ring, and the amino alcohols are obtained in good yields.

Fixation and Activation of Carbon Dioxide on Aluminum Porphyrin. Catalytic Formation of Carbamic Ester from Carbon Dioxide, Amine, and Epoxide

Carbon dioxide is trapped by (5,10,15,20-tetraphenylporphinato)aluminum acetate in the presence of a secondary amine in the form of an aluminum carbamate on the opposite side to the acetate group with respect to the porphyrin plane.Carbon dioxide thus trapped by aluminum porphyrin is activated enough to undergo a catalytic reaction involving secondary amine and epoxide to afford dialkylcarbamic ester under atmospheric pressure at room temperature.

Stereospecific Palladium-Promoted Oxyamination of Alkenes

A method for direct oxyamination of olefins to vicinal amino alcohol derivatives is described. The reaction proceeds via an aminopalladation-oxidation sequence.Terminal olefins give good yields (60-80percent) whereas internal olefins give lower yields (20-60percent).The oxyamination reaction is stereospecific as shown by reaction of (Z)- and (E)-2-butene and (E)-1-deuterio-1-decene and proceeds by overall cis stereochemistry.The stereochemical outcome is a result of a trans aminopalladation followed by an oxidative cleavage of the palladium carbon bond with inversion of configuration at carbon.Oxidation of the organopalladium ? complex to give an oxidized palladium intermediate, which could be a Pd(IV) intermediate, followed by SN2-type nucleophilic displacement of palladium is the most likely mechanism for the oxidative cleavage reaction.