43029-44-3

Usage

InChI:InChI=1/C15H10N4S/c1-3-7-11(8-4-1)13-16-17-15-19(13)18-14(20-15)12-9-5-2-6-10-12/h1-10H

Upstream product

• 2231-57-4 Thiocarbohydrazide 
• 65-85-0 benzoic acid 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 96133-99-2 C₁₀H₁₃N₃OS 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 49580-00-9 2-benzylidene-1-(5-phenyl-1,3,4-thiadiazol-2-yl)hydrazine 
• 75-05-8 acetonitrile 
• 13373-11-0 2-chloro-5-phenyl-[1,3,4]thiadiazole 
• 13229-03-3 2-hydrazino-5-phenyl-1,3,4-thiadiazole 
• 613-94-5 benzoic acid hydrazide 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 98-88-4 benzoyl chloride 
• 22706-11-2 4-amino-3-phenyl-1H-1,2,4-triazole-5(4H)-thione 
• 13229-05-5 benzoic acid N'-(5-phenyl-[1,3,4]thiadiazol-2-yl)-hydrazide 

Downstream Products

• 1390650-25-5 Co(4,7-diphenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole)2Cl₂ 
• 1390650-24-4 Zn(4,7-diphenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole)2Cl₂ 

Relevant academic research and scientific papers

3. 6 - Disubstituted [1, 2, 4] triazolo [3, 4 - b] [1, 3, 4] thiadiazole compound and use thereof

The invention discloses 3,6-disubstituted[1,2,4]triazolyl[3,4-b][1,3,4]thiadiazole compounds represented by general formula (I), and pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof. The compounds can be used as a transpeptidase SrtA inhibitor of Staphylococcus aureus, Bacillus pyogenes, Bacillus anthracis, Streptococcus pneumoniae and other Gram-positive bacteria, and can be used to prepare drugs for treating pathogen infection diseases with the transpeptidase SrtA of the Gram-positive bacteria, such as Staphylococcus aureus, Bacillus pyogenes, Bacillus anthracis and Streptococcus pneumoniae as target. The compounds avoid selection pressure induced drug resistance of pathogens to a certain degree, and mitigate threat of continuous drug-resistant pathogens to the health of human.

Metal-organic coordination architectures of condensed heterocyclic based 1,2,4-triazole: Syntheses, structures and emission properties

In efforts to explore the effects of metal ions, ligand structures, counteranions on the structures and properties of metal-organic complexes, seven d10 metals (Zn and Cd) and transition metals (Cu and Co) coordination compounds with condensed

Anodic formation of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and 2(3-aryl-5-methyl-1H-[1,2,4]triazol-1-yl)-5-aryl-1,3,4-thiadiazoles

3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles together with the unknown systems 2-(3-aryl-5-methyl-1H-[1,2,4]triazol-1-yl)-5-aryl-1,3,4- thiadiazoles were obtained by anodic oxidation, under aprotic conditions, of aryl aldehyde N-(5-aryl-1,3,

Silica-supported dichlorophosphate as a recoverable cyclodehydrant: Expeditious synthesis of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles under microwave irradiation

An expeditious novel approach to 3,6-disubstituted [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazoles using silica-supported dichlorophosphate as a recoverable cyclodehydrant, carboxylic acids and thiocarbohydrazide as starting materials, and microwave irradiatio

Microwave-enhanced reactions of 4-amino-5-merecapto-1,2,4-triazoles with benzoyl chloride and aromatic aldehydes

The microwave-enhanced reactions of 4-amino-5-mercapto-3-substituent-1,2,4- triazoles with benzoyl chloride or arylaldehydes under solvent-free conditions without catalyst were studied. 3-Substituded-6-phenyl-1,2,4-triazolo[3,4-b]-1,3, 4-thiadiazoles were

3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: Synthesis and evaluation for antimicrobial and antiviral activity. III

A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4- b][1,3,4]thiadiazole derivatives was prepared and tested to evaluate their antimycotic, antibacterial and anti-HIV-1 activities. The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the 5-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles which in turn allows an easier preparation of the 1,2,4- triazolo[3,4-b] [1,3,4]thiadiazole ling system. All tested compounds didn't show any significant activity.

1,2,4-Triazoles. Improved Synthesis of 5-Substituted 4-Amino-3-mercato-(4H)-1,2,4-triazoles and a Facile Route to 3,6-Disubstituted 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazoles

The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the 5-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles. The crude 4-amino-5-mercapto-1,2,4-triazoles react easily with carboxylic acids or carboxylic acid chlorides to afford the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole ring system.

Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives

The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.

Derives de la dihydro-2,4 triazole-1,2,4 thione-3 et de l'amino-2 thiadiazole-1,3,4 a partir de nouvelles thiosemicarbazones d'esters

A new general synthesis of 4,5-disubstituted 2,4-dihydro-1,2,3-triazole-3-thiones is proposed.These heterocycles are obtained by the action of primary amines, aralhydrazines or aroylhydrazines on the thiosemicarbazones of esters.These last compounds are prepared by action of chlorhydrates of iminoesters on thiosemicarbazide in dimethylformamide.These thiosemicarbazones react also with strong acids, acid anhydrides and chlorides; by thermolysis and they give 2-amino-1,3,4-thiadiazole derivatives.Also, two derivatives of 1,2,4-triazolo-1,3,4-thiadiazole have been prepared.

Synthesis and Pharmacology of 2-Aryl/aralkyl-5-aryl/aralkyl/diaralkyl-s-triazolo-1,3,4-thiadiazoles

A series of s-triazolo-1,3,4-thiadiazoles (III) carrying aryl or aralkyl group at 2-position and aryl, aralkyl or diaralkyl group at 5-position have been synthesised and evaluated for their biological activities.Some of the compounds exhibit strong CNS depressant and mild to moderate antiinflammatory action in experimental animals.