4381-32-2

Upstream product

• 5029-67-4 2-iodopyridine 
• 108-90-7 chlorobenzene 
• 109-04-6 2-bromo-pyridine 
• 1008-89-5 2-phenylpyridine 
• 98-80-6 phenylboronic acid 
• 1448009-89-9 benzo[h]quinoline 
• 98-98-6 2-Picolinic acid 
• 675-20-7 piperidin-2-one 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 694-59-7 pyridine N-oxide 
• 694-80-4 2-bromo-1-chlorobenzene 
• 109-09-1 2-chloropyridine 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 615-41-8 2-iodochlorobenzene 

Downstream Products

• 1217887-31-4 C₁₂H₇ClF₃N 
• 879088-40-1 2-(2-chloro-5-nitrophenyl)-pyridine 
• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 
• 879085-55-9 vismodegib 
• 33421-18-0 2-(2-chlorophenyl)-pyridine-N-oxide 
• 485385-78-2 2-{2-[2-(trimethylsilyl)ethynyl]phenyl}pyridine 
• 478944-03-5 2-(2-vinylphenyl)pyridine 
• 1044209-44-0 C₁₁H₉ClN₂ 

Relevant academic research and scientific papers

Light-promoted C-Cl bond-forming reductive elimination of a metal-metal bonded PdIII-PdIIIcomplex

The excited-state reductive elimination (RE) activities of a metal-metal bonded PdIII2complex, [(2-phenylpyridyl)Pd(μ-acetate)Cl]2, are described. The C-Cl bond-forming RE reaction is accelerated by up to five orders of magnitude upon visible p

Synthesis and Molecular Structure of Pseudo-Hexacoordinated Pnictines Bearing 2-Phenylpyridine Ligands

The pseudo-hexacoordinated organo-pnictogen(III) compounds tris[2-(2-pyridyl)phenyl]stibine [(ppy)3Sb, 1] and tris[2-(2-pyridyl)phenyl]bismuthine [(ppy)3Bi, 2], which bear three 2-phenylpyridine (ppy) ligands, were prepared and isola

Hypercrosslinked Polymer Platform-Anchored Single-Site Heterogeneous Pd-NHC Catalysts for Diverse C-H Functionalization

We demonstrate a new class of hypercrosslinked polymer (HCP) platform-Anchored single-site heterogenized Pd-NHC catalysts for multipurpose C-H functionalization reactions. This new class is represented by a set of three catalysts, viz., HCP-B-MeNHC-Pd, HCP-B-BnNHC-Pd, and HCP-TPM-MeNHC-Pd, having a variation on the structural feature of the anchoring polymeric platform. All three catalysts were fully characterized via diverse solid-state characterization and analytical techniques such as X-ray photoelectron spectroscopy, 13C cross-polarization magic-Angle-spinning nuclear magnetic resonance, field-emission scanning electron microscopy, energy-dispersive X-ray analysis, thermogravimetric analysis, and inductively coupled plasma-optical emission spectrometry. Three types of regularly practiced and very useful C-H functionalization reactions, viz., C-H halogenation, acetoxylation, and arylation, are tested with the new catalysts and found to be highly compatible and successful. With the HCP-TPM-MeNHC-Pd catalyst, up to 85, 75, and 70% yields of the functionalized products were achieved for the halogenation, acetoxylation, and arylation reactions, respectively. Demanding attributes such as enhanced activity, heterogeneity, and recyclability are offered by this new system, making it a promising candidate in the field of heterogeneous C-H functionalization, where only a few efficient catalysts are available.

Tris-NHC-propagated self-supported polymer-based Pd catalysts for heterogeneous C-H functionalization

Three-dimensionally propagated imidazolium-containing mesoporous coordination polymer and organic polymer-based platforms were successfully exploited to develop single-site heterogenized Pd-NHC catalysts for oxidative arene/heteroarene C-H functionalization reactions. The catalysts were efficient in directed arene halogenation, and nondirected arene and heteroarene arylation reactions. High catalytic activity, excellent heterogeneity and recyclability were offered by these systems making them promising candidates in the area of heterogeneous C-H functionalization, where efficient catalysts are still scarce.

Salen-based hypercrosslinked polymer-supported Pd as an efficient and recyclable catalyst for C-H halogenation

In this work, we report the first use of a salen-based hypercrosslinked polymer-supported Pd catalyst to carry out C-H halogenation. This catalyst can effectively catalyze C-H bromination and chlorination even better than its homogeneous counterpart Pd(OAc)2. It also showed excellent reusability without loss of catalytic activity for ten cycles. A broad substrate scope was explored and moderate to excellent yields were obtained.

Cu-catalyzed direct ortho-chlorination/-oxygenation of aryls: Switching of oxidant, control the diversity of products

Highly regioselective copper catalyzed ortho-chlorination of aryl pyridines was achieved with TBHP as oxidant and 1,2-dichloroethane as chlorinating agent for the first time. Switching the oxidant from TBHP to benzoyl peroxide under identical reaction conditions effects ortho-oxygenation.

Copper(II)-Promoted Mono-Selective ortho C-H Chlorination of Arenes by Using Trimethyl(trichloromethyl)silane

The first example of a Cu-promoted ortho -chlorination of aryl C-H bonds by using TMSCCl 3 as chlorinating agent is reported. This reaction features a high selectivity toward monochlorination over dichlorination, compatibility with a variety of

Synthetic Path To Pharmaceutically Acceptable Vismodegib

The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable pharmaceutical compositions and the use of the compound for the treatment of basal-cell carcinomas

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

Structure–activity comparison in palladium–N–heterocyclic carbene (NHC) catalyzed arene C[sbnd]H activation- functionalization

A simple and efficient C[sbnd]H activation catalyst was identified through a model structure-activity screening applied to a noncooperative, nonsymmetric bimetallic palladium(II)-N-heterocyclic carbene complex. Mechanistic studies based on kinetics and DOSY NMR spectroscopy provided the origin of the higher efficiency of the identified catalyst.