475479-10-8

Usage

Uses

Used in Pharmaceutical Industry:
C₁₆H₁₆N₂O₅ is used as an intermediate in the synthesis of β-methoxyacrylate analogs for their antifungal activity. These analogs have potential applications in the development of new antifungal drugs to combat various fungal infections.
Used in Agricultural Industry:
C₁₆H₁₆N₂O₅ can be utilized as a starting material for the development of antifungal agents targeting plant pathogens. This application can contribute to the protection of crops and the enhancement of agricultural productivity by reducing the impact of fungal diseases on plants.
Used in Cosmetics Industry:
The antifungal properties of C₁₆H₁₆N₂O₅ and its analogs can also be harnessed in the cosmetics industry for the development of products that address fungal infections affecting the skin, such as athlete's foot or nail fungus.
Used in Research and Development:
C₁₆H₁₆N₂O₅ serves as a valuable compound for researchers in the field of medicinal chemistry and pharmaceuticals. It can be used to study the structure-activity relationship of β-methoxyacrylate analogs and to develop new antifungal agents with improved efficacy and reduced side effects.

Upstream product

• 40800-90-6 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone 
• 175971-61-6 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester 
• 143230-42-6 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionic acid methyl ester 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 67-56-1 methanol 
• 131860-97-4 (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate 
• 553-86-6 benzofuran-2(3H)-one 
• 383428-73-7 3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate 
• 124-41-4 sodium methylate 

Relevant academic research and scientific papers

[(6 - Substituted - pyrimidine -4 - oxyacetyl) phenyl] -3 - methoxy methyl acrylate (by machine translation)

The invention has the activity of inhibiting crop bacteria [(6 - substituted - pyrimidine - 4 - oxyacetyl) phenyl] - 3 - methoxy methyl acrylate, relates to the technical field of biochemistry. It has the following general structure: It is inhibiting the cucumber wilt disease, peanut pinguis bacteria, germ, galenical wheat, maize leaf spot, watermelon anthrax bacteria, donor bacteria and other applications has good activity. (by machine translation)

Design, synthesis, and antifungal activities of new β-methoxyacrylate analogues

Strobilurins have become one of the most important classes of agricultural fungicides. To search for new strobilurin derivatives with high activity against resistant pathogens, a series of new β-methoxyacrylate analogues containing substituted pyrimidine in the side chain with strobilurin pharmacophore were synthesized and their biological activities were tested. The compounds were confirmed and characterized by 1H-NMR, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activities against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at a concentration of 50 μg mL-1. Notably, compound 1b (R = 2,5-dimethylphenyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin.