4913-77-3

Upstream product

• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 
• 5089-33-8 2-(4-bromophenyl)-1,1,1,3,3,3-hexamethyldisilazane 
• 104-88-1 4-chlorobenzaldehyde 
• 62-53-3 aniline 
• 873-76-7 para-Chlorobenzyl alcohol 
• 201230-82-2 carbon monoxide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 540-37-4 p-aminoiodobenzene 
• 17151-48-3 tributyl(4-chlorophenyl)stannane 
• 74-11-3 para-chlorobenzoic acid 
• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 
• 108-90-7 chlorobenzene 
• 100-14-1 4-nitrobenzyl chloride 
• 30203-94-2 1-chloro-4-(4-nitrobenzyl)benzene 

Downstream Products

• 118040-71-4 4-chloro-4'-(1H-pyrrol-1-yl)benzophenone 
• 71783-49-8 4-ethoxy-4'-chloro-benzophenone 
• 134-85-0 4-chlorobenzophenone 
• 130343-66-7 [6]quinolyl-(4-chloro-phenyl)-methanol 
• 855609-58-4 (4-chloro-phenyl)-(1,2,3,4-tetrahydro-[6]quinolyl)-ketone 
• 139442-22-1 N-[4-(4-chlorobenzoyl)phenyl],5-ethylisoxazole-4-carboxamide 
• 1354385-76-4 4-amino-6-(4-chlorobenzoyl)-2(1H)-quinazolinone 
• 1354385-67-3 2-amino-5-(4-chlorobenzoyl)benzonitrile 
• 1354385-55-9 (4-amino-3-iodophenyl)(4-chlorophenyl)methanone 
• 439868-56-1 (4-chlorophenyl)(4-methyl-6-quinolinyl)-methanone 
• 93276-32-5 4-amino-3,4',5-trichloro-benzophenone 

Relevant academic research and scientific papers

DIPHENYL DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Coumarin-surfactant modified polyoxometalate catalyzed cross dehydrogenative coupling of benzyl alcohol with the: Para -C-H of unprotected aniline

This paper presents a novel method for synthesizing para-aminobenzophenone and its derivatives (p-ABPs) using a coumarin-surfactant modified polyoxometalate as the catalyst. Preliminary mechanistic studies indicate that the reaction has undergone an oxidative cross dehydrogenative coupling process. This method has the advantages of an easy process, a convenient raw material source, safe and green oxidants, and tolerances of several functional groups.

QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS

The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders

QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS

The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders

Palladacycle-Catalyzed Carbonylative Suzuki-Miyaura Coupling with High Turnover Number and Turnover Frequency

This work reports the carbonylative Suzuki-Miyaura coupling of aryl iodides catalyzed by palladacycles. More importantly, the palladacycles have been used to generate high turnover numbers (TON's) and turnover frequencies (TOF's). A range of aryl iodides can be coupled with arylboronic acids, generating TON's in the range of 106 to 107 and TOF's in the range of 105 to 106 h-1. Comparison of the palladacycles with a conventional palladium source shows their superiority in generating high TON's and TOF's.

METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T

The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

ARYL-AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI3-KINASE SIGNALLING PATHWAYS

The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Synthesis, molecular modelling and biological evaluation of 4-amino-2(1H)-quinazolinone and 2,4(1H,3H)-quinazolidone derivatives as antitumor agents

A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)- quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines. A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)- quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines. Copyright

The first heterogeneous carbonylative Stille coupling of organostannanes with aryl iodides catalyzed by MCM-41-supported bidentate phosphine palladium(0) complex

The first heterogeneous carbonylative Stille coupling reaction of organostannanes with aryl iodides under an atmospheric pressure of carbon monoxide has been achieved in DMF at 80 °C in the presence of a catalytic amount of an MCM-41-supported bidentate phosphine palladium(0) complex [MCM-41-2P-Pd(0)], yielding a variety of unsymmetrical ketones in good to high yields. This polymeric palladium catalyst exhibited higher activity and selectivity than PdCl2(PPh3)2 and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decrease in activity. Our system not only avoids the use of carbon monoxide under pressure, but also solves the basic problem of palladium catalyst recovery and reuse. The Royal Society of Chemistry 2009.