496-67-3 Usage
Chemical Properties
White Solid
Originator
Bromisovalum,Linhai Duqiao Fine
Chemical Factory
Uses
2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names.
Definition
ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.
Manufacturing Process
A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at
70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2-
Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting
point 149°C.
Brand name
Bromural (Knoll).
Therapeutic Function
Sedative, Hypnotic
World Health Organization (WHO)
Bromisoval is a monureide sedative of long standing. It remains
available in several countries. However, it releases the bromide ion and prolonged
usage can result in chronic bromide accumulation and intoxication.
Safety Profile
Moderately toxic by
ingestion. Human systemic effects by
ingestion: nausea or vomiting, and coma. A
sedative and hypnotic agent. When heated
to decomposition it emits very toxic fumes
of Brand NOx
Purification Methods
Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.]
Check Digit Verification of cas no
The CAS Registry Mumber 496-67-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 496-67:
(5*4)+(4*9)+(3*6)+(2*6)+(1*7)=93
93 % 10 = 3
So 496-67-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H11BrN2O2/c1-3(2)4(7)5(10)9-6(8)11/h3-4H,1-2H3,(H3,8,9,10,11)/t4-/m0/s1
496-67-3Relevant academic research and scientific papers
A bromine mi suofa synthetic method (by machine translation)
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Paragraph 0026; 0030-0033; 0037-0039; 0044-0046; 0051-0053, (2018/09/08)
The present invention provides a method for synthesis of bromine mi suofa, belongs to the technical field of drug synthesis, comprising the following steps: S1, in order to α - bromo isovaler ic acid as the raw material, in order to N, N - dimethyl formamide catalytic, adds by drops the chlorination sulfoxide solvent, reaction to obtain the α - bromo different pivaloyl chloride; S2, to S1 obtained in the bromo different α - pivaloyl chloride react with urea, condense and get [...]-cutting crude; S3, refining to obtain [...]-cutting works. The present invention provides a method of synthesis of bromine mi suofa, can effectively avoid the generation of chlorinated by-products, simple process flow, the requirements for apparatus is relatively low, the yield of the product and high purity, and is favorable for industrial production. (by machine translation)
