5038-46-0

Upstream product

• 4707-47-5 2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester 
• 4707-46-4 2,4-dihydroxy-3,6-dimethylbenzoic acid 
• 34883-14-2 2,4-dihydroxy-3,6-dimethylbenzaldehyde 
• 479-20-9 atranorin 
• 186581-53-3 diazomethane 
• 20372-89-8 4-(2,4-dihydroxy-3,6-dimethylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoic acid 
• 56410-31-2 ethyl 4-benzyloxy-2-hydroxy-3,6-dimethylbenzoate 
• 56410-32-3 4-benzyloxy-2-hydroxy-3,6-dimethylbenzoic acid 
• 31581-32-5 ethyl 2,4-dihydroxy-3,6-dimethylbenzoate 

Relevant academic research and scientific papers

Depsides: Lichen metabolites active against hepatitis C virus

A thorough phytochemical study of Stereocaulon evolutum was conducted, for the isolation of structurally related atranorin derivatives. Indeed, pilot experiments suggested that atranorin (1), the main metabolite of this lichen, would interfere with the li

Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid

A series of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O-demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. Because the compounds did not show appreciable reactivity against a stable free radical, 2,2-diphenyl-1-picrylhydrazyl, and did not produce appreciable amounts of deoxyribose degradation as a measure of their potency to generate hydroxyl radicals, a simple redox effect could not explain their biological activity. Also, there was no nonspecific cytotoxicity as documented by the activity of lactate dehydrogenase released from the cytoplasm of keratinocytes, which was in the control range.

New Depsides from Erioderma Lichens

A chemosyndrome of para-depsides based on methyl 4-O-demethylbarbatate (3) has been detected in Erioderma lichens and the structures of the metabolites have been established by unambiguous syntheses.New depsides include methyl 5-chloro-4-O-demethylbarbata