6302-84-7

Basic information

• Product Name: 2-(4-Methoxyphenyl)-1-imidazoline
• Synonyms: 2-(4-Methoxyphenyl)-1-imidazoline;2-(4-Methoxyphenyl)-2-imidazoline;1H-IMidazole, 4,5-dihydro-2-(4-Methoxyphenyl)-;4,5-dihydro-2-(4-methoxyphenyl)-1H-Imidazole;2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole
• CAS NO: 6302-84-7
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Mol File: 6302-84-7.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 291.4°C at 760 mmHg
• Flash Point: 130.1°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.00195mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 2-(4-Methoxyphenyl)-1-imidazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxyphenyl)-1-imidazoline(6302-84-7)
• EPA Substance Registry System: 2-(4-Methoxyphenyl)-1-imidazoline(6302-84-7)

Safety Data

• Hazardous Substances Data: 6302-84-7(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxyphenyl)-1-imidazoline is a chemical compound that belongs to the imidazoline class of compounds. It consists of an imidazoline ring with a 4-methoxyphenyl group attached at the 2-position. 2-(4-Methoxyphenyl)-1-imidazoline is known to have various biological activities and is used in the field of pharmacology. It has been studied for its potential effects on the cardiovascular system and has been suggested as a potential treatment for hypertension. Additionally, 2-(4-Methoxyphenyl)-1-imidazoline has also been investigated for its potential use as an anti-inflammatory agent and as a potential treatment for type 2 diabetes. Overall, this compound has shown promise as a potential therapeutic agent in various areas of medicine.

InChI:InChI=1/C10H12N2O/c1-13-9-4-2-8(3-5-9)10-11-6-7-12-10/h2-5H,6-7H2,1H3,(H,11,12)

Upstream product

• 107-15-3 ethylenediamine 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 119072-55-8 tert-butylisonitrile 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 66107-29-7 4-methoxyphenyl triflate 
• 39082-40-1 1-[2-(4-methoxyphenyl)ethynyl]-4-nitrobenzene 
• 608533-22-8 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-one 
• 105-13-5 4-Methoxybenzyl alcohol 
• 874-90-8 4-methoxybenzonitrile 
• 100-09-4 4-methoxybenzoic acid 
• 78-09-1 orthocarbonic acid tetraethyl ester 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 212485-91-1 2-(4-hydroxyphenyl)-4,5-dihydro-1H-imidazole 
• 65111-64-0 2-(4-methoxy-phenyl)-1-[1β-oxo-6β-(2-phenyl-acetylamino)-1λ⁴-penicillanoyl]-4,5-dihydro-1H-imidazole 
• 52091-37-9 2-[4-(methyloxy)phenyl]-1H-imidazole 
• 1301603-06-4 C₂₉H₄₉N₂O⁽¹⁺⁾*I^(1-) 
• 137208-86-7 4-(1-methyl-1H-imidazol-2-yl)phenol 
• 123-11-5 4-methoxy-benzaldehyde 
• 22459-57-0 2,4,6-triphenylverdazyl 

Relevant articles and documents

Visible Light-Promoted Aryl Azoline Formation over Mesoporous Organosilica as Heterogeneous Photocatalyst

N-heterocyclic compounds demonstrate wide applications ranging from natural compound production to coordination chemistry. Usually, the synthesis of N-heterocyclic compounds is conducted under thermal conditions, mostly by Lewis acids or metal-containing compounds as molecular catalysts. Here, we report a photocatalytic route for aryl azoline formation by mesoporous organosilica as visible light-active and heterogeneous photocatalyst. Via formation of aromatic aldehydes with various amines, 2-phenyl-2-imidazoline, 2-phenyl-2-oxazoline, 2-phenyl-2-thiazoline and their derivatives could be formed with high conversion and selectivity. Additionally, the organosilica photocatalyst showed high stability and reusability.

Green Synthesis of 2-Substituted Imidazolines using Hydrogen Peroxide Catalyzed by Tungstophosphoric Acid and Tetrabutylammonium Bromide in Water

Various 2-substituted imidazolines were constructed from aromatic aldehydes with ethylenediamine using hydrogen peroxide as an oxidant in water. Tungstophosphoric acid (HPW) was found to be active for this transformation due to its ubiquitous catalytic and oxidative nature, and further combination of tetrabutylammonium bromide (TBAB) made this transformation more efficient and attractive. It was found that the yields of the corresponding 2-substituted imidazolines were markedly influenced by the position and nature of the substituents on the phenyl ring. A plausible mechanism was also proposed to clarify this catalytic oxidative system.

Synthesis of tetrazoles, triazoles, and imidazolines catalyzed by magnetic silica spheres grafted acid

The magnetically separable catalysts are used in the synthesis of N-containing heterocycles, including tetrazoles, triazoles, and imidazolines. The magnetic silica sphere grafted sulfonic acid (MSS-SO3H) is suitable for the synthesis of 1,2,3-triazole via the cycloaddition of nitroalkene with NaN3, whereas the zinc-modified silica sphere catalyst (MSS-SO3Zn) is more suitable for the synthesis of tetrazoles. The MSS-SO3Zn catalyst also works well for the synthesis of 2-substituted imidazoline via the condensation of nitriles with ethylenediamine. Both of the MSS-SO3H and MSS-SO3Zn catalysts can be recovered easily by a magnet, and they can be reused without further tedious activation.