52345-47-8

Usage

Uses

Used in Pharmaceutical Development:
2-((4-METHYLPHENYL)SULFONYL)ETHANAMIDE is used as a building block in the pharmaceutical industry for the synthesis of various drugs and biologically active compounds. Its unique sulfonyl group and reactivity contribute to the creation of novel therapeutic agents with potential applications in treating a range of medical conditions.
Used in Organic Synthesis:
In the field of organic chemistry, 2-((4-METHYLPHENYL)SULFONYL)ETHANAMIDE serves as a key intermediate in the synthesis of complex organic molecules. Its versatile chemical properties allow for its incorporation into a wide array of chemical structures, facilitating the development of new materials and compounds with diverse applications.
Used in Medicinal Chemistry Research:
2-((4-METHYLPHENYL)SULFONYL)ETHANAMIDE is utilized as a research tool in medicinal chemistry to explore its potential as a precursor for the development of new pharmaceuticals. Its unique structure and reactivity provide opportunities for the design and synthesis of innovative biologically active molecules with therapeutic potential.

InChI:InChI=1/C9H11NO3S/c1-7-2-4-8(5-3-7)14(12,13)6-9(10)11/h2-5H,6H2,1H3,(H2,10,11)

Upstream product

• 110-89-4 piperidine 
• 123-91-1 1,4-dioxane 
• 55490-03-4 bromo-(toluene-4-sulfonyl)-acetic acid amide 
• 2850-19-3 (toluene-4-sulfonyl)-acetic acid ethyl ester 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 79-07-2 Chloroacetamide 
• 7732-18-5 water 
• 7803-57-8 hydrazine hydrate 
• 56185-22-9 dibromo-(toluene-4-sulfonyl)-acetic acid amide 
• 10034-85-2 hydrogen iodide 
• 64-19-7 acetic acid 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 5697-44-9 p-tolylsulfonylmethyl isocyanide 
• 3937-96-0 tosylacetic acid 

Downstream Products

• 871893-56-0 3-(toluene-4-sulfonyl)-quinolin-2-ol 
• 61053-61-0 2-Methanesulfonyl-2-(toluene-4-sulfonyl)-acetamide 
• 41317-66-2 p-Methylphenyl-<2.2-(ethylendithio)vinyl>sulfon 
• 31350-39-7 dibromomethyl-p-tolyl sulfone 
• 55490-03-4 bromo-(toluene-4-sulfonyl)-acetic acid amide 
• 56185-22-9 dibromo-(toluene-4-sulfonyl)-acetic acid amide 
• 855881-88-8 dichloro-(toluene-4-sulfonyl)-acetic acid amide 
• 54334-58-6 2-(toluene-4-sulfonyl)-thioacetamide 
• 37891-95-5 bromomethyl 4-tolyl sulfone 
• 26958-47-4 1,1-Di-methylthio-2-tosylethen 
• 99972-93-7 4-(toluene-4-sulfonyl)-pyrrolidine-2,3,5-trione 

Relevant academic research and scientific papers

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

A Concise Route to 2-Sulfonylacetonitriles from Sodium Metabisulfite

A three-component reaction of aryldiazonium tetrafluoroborates, sodium metabisulfite, and 3-azido-2-methylbut-3-en-2-ol under mild conditions is described. By using abundant and cheap sodium metabisulfite as the sulfur dioxide surrogate, this protocol features good functional group compatibility, affording 2-arylsulfonylacetonitriles in moderate to good yields. The reaction proceeds smoothly at room temperature without the need of any catalysts or additives. Moreover, the synthetic utility of this method is demonstrated by the transformation of 2-arylsulfonylacetonitrile into 2-arylsulfonyl acetamide and 2-arylsulfonylethylamine. (Figure presented.).