52889-83-5

Basic information

• Product Name: 4-(methoxymethyl)benzyl chloride
• Synonyms: 4-(methoxymethyl)benzyl chloride;1-(chloromethyl)-4-(methoxymethyl)benzene
• CAS NO: 52889-83-5
• Molecular Formula: C₉H₁₁ClO
• Molecular Weight: 170.64
• Mol File: 52889-83-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(methoxymethyl)benzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methoxymethyl)benzyl chloride(52889-83-5)
• EPA Substance Registry System: 4-(methoxymethyl)benzyl chloride(52889-83-5)

Safety Data

• Hazardous Substances Data: 52889-83-5(Hazardous Substances Data)

Upstream product

• 6770-38-3 1,4-dimethoxymethyl benzene 
• 75-36-5 acetyl chloride 
• 124-41-4 sodium methylate 
• 623-25-6 p-Xylylene dichloride 
• 71831-21-5 4-(bromomethyl)benzyl alcohol 
• 538316-01-7 1,1-dimethylethyl 4-(methoxymethyl)benzoate 
• 67003-50-3 4-(Methoxymethyl)benzoic acid 
• 1719-82-0 p-methoxymethylbenzoic acid methyl ester 
• 62172-89-8 4-methyloxymethylhydroxymethylhydroxymethylcyclohexane 

Downstream Products

• 93943-06-7 4-(methoxymethyl)benzaldehyde 
• 1432496-21-3 1-(azidomethyl)-4-(methoxymethyl)benzene 
• 132719-05-2 (4-(methoxymethyl)phenyl)methanamine 
• 855272-02-5 diethyl-(4-bromomethyl-benzyl)-amine 
• 91271-57-7 (4-((diethylamino)methyl)phenyl)methanol 
• 67003-50-3 4-(Methoxymethyl)benzoic acid 
• 73291-09-5 4-chloromethylbenzaldehyde 
• 855271-71-5 diethyl-(4-methoxymethyl-benzyl)-amine 
• 119991-79-6 4-(methoxymethyl)benzyl acetate 
• 62172-89-8 4-methyloxymethylhydroxymethylhydroxymethylcyclohexane 

Relevant articles and documents

ANTIBIOTIC RESISTANCE BREAKERS

The invention relates to antibiotic compounds of formula (A1) and pharmaceutically acceptable salts, solvates, tautomers and combinations thereof, wherein X and L are optional linkers and one of RA or R1 comprises Ar1, wherein Ar1 is an antibiotic resistance breaker moiety which comprises an optionally substituted C6-10 aryl, C7-13 aralkyl, C5-10 heteroaryl, C6-13 heteroaralkyl, C5-10 heterocyclyl, C6-13 heterocyclalkyl, C3-10 carbocyclyl, C4-13 carbocyclalkyl, -C(=NR')-NR'R'' or –CH2- CH=CH2 group; wherein after administration of the compound to a bacterial infection this moiety reduces or prevents efflux. The invention also discloses pharmaceutical compositions comprising compounds of formula (A1) and the use of such compounds as medicaments, in particular, to treat bacterial infections, such as drug-resistant bacterial infections.

Oxidation of benzylic alcohols and ethers to carbonyl derivatives by nitric acid in dichloromethane

Nitric acid in dichloromethane may be successfully employed for the oxidation of benzylic alcohols and ethers to the corresponding carbonyl compounds. The proposed method proved to be of general applicability, affording very good yields of aldehydes and ketones and showing interesting chemoselectivity in many instances, allowing competitive aromatic nitration to be avoided, as well as - in the case of aldehydes - any further oxidation to carboxylic acids. The reaction probably proceeds by a radical mechanism, the active species in the oxidation process being NO2. Competitive formation of nitro esters was observed in some cases, whereas poor results were obtained with allylic and non-benzylic substrates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.