53908-65-9

Usage

Uses

Used in Pharmaceutical Industry:
(Acetylamino)(3-oxopropyl)malonic acid diethyl ester is used as a reagent for the hydrogenation and biosynthesis of lupin alkaloids, which are of significant interest in the pharmaceutical industry due to their potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, (Acetylamino)(3-oxopropyl)malonic acid diethyl ester is utilized as a key intermediate in the production of various complex organic molecules, contributing to the development of new compounds with diverse applications.

Upstream product

• 5440-42-6 ethyl 2-acetamido-4-cyano-2-ethoxycarbonylbutanoate 
• 141-52-6 sodium ethanolate 
• 107-02-8 acrolein 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 35573-93-4 3-chloro-1,1-diethoxy-propane 

Downstream Products

• 2906-39-0 Δ¹-pyrroline-5-carboxylate 
• 6297-96-7 acetylamino-(3-phenylhydrazono-propyl)-malonic acid diethyl ester 
• 56161-88-7 2-acetylamino-2-{3-[(2,4-difluoro-phenyl)-hydrazono]-propyl}-malonic acid diethyl ester 
• 609-36-9 rac-Pro-OH 
• 117614-91-2 ethyl N-acetyl-O-p-toluenesulfonyl-2-amino-2-ethoxycarbonyl-5-hydroxypentanoate 
• 101886-35-5 acetylamino-[3-(4-sulfamoyl-phenylhydrazono)-propyl]-malonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of 2-Amino-5-hydroxy-5-phosphonovaleric Acid

The synthesis of a new analog of 2-amino-5-phosphonovaleric acid (AP5), namely 2-amino-5-hydroxy-5-phosphonovaleric acid, by successive Michael addition of acetamidomalonic ester to acrolein and Abramov’s phosphorylation of the aldehydes formed in situ was developed.

BICYCLIC ACYLTRYPTOPHANOLS

The present invention relates to acyltryptophanols of the general formula (I), in which Q, V, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

Remarkable Nucleophilic Activity of N-Acetamido Group. Synthesis of Proline and Lysine for Biosynthetic Purposes

DL-Proline 7 was prepared from acroleine 1 and diethyl N-acetylaminomalonate 2 in 22percent overall yield.The key step was an intramolecular substitution of tosyloxy group in 4b by N-acetylamino group.The tosylate 4b was also an intermediate in synthesis of (6-13C) lysine.Pronounced differences in incorporation of (6-13C) and lysine to lupanine 12 were observed.